{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:22:17Z","timestamp":1787955737263,"version":"build-2784847793"},"reference-count":66,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["FKZ 3IHS024D"],"award-info":[{"award-number":["FKZ 3IHS024D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["241879"],"award-info":[{"award-number":["241879"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["643809"],"award-info":[{"award-number":["643809"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["E\/U2AD\/ID018\/IF557"],"award-info":[{"award-number":["E\/U2AD\/ID018\/IF557"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FKZ 3IHS024D"],"award-info":[{"award-number":["FKZ 3IHS024D"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["241879"],"award-info":[{"award-number":["241879"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["643809"],"award-info":[{"award-number":["643809"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["E\/U2AD\/ID018\/IF557"],"award-info":[{"award-number":["E\/U2AD\/ID018\/IF557"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sanit\u00e4tsakademie der Bundeswehr","award":["FKZ 3IHS024D"],"award-info":[{"award-number":["FKZ 3IHS024D"]}]},{"name":"Sanit\u00e4tsakademie der Bundeswehr","award":["241879"],"award-info":[{"award-number":["241879"]}]},{"name":"Sanit\u00e4tsakademie der Bundeswehr","award":["643809"],"award-info":[{"award-number":["643809"]}]},{"name":"Sanit\u00e4tsakademie der Bundeswehr","award":["E\/U2AD\/ID018\/IF557"],"award-info":[{"award-number":["E\/U2AD\/ID018\/IF557"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human multipotent mesenchymal stromal cells (hMSCs) are of significant therapeutic interest due to their ability to deliver oncolytic adenoviruses to tumors. This approach is also investigated for targeting head and neck squamous cell carcinomas (HNSCCs). HAdV-5-HexPos3, a recently reported capsid-modified vector based on human adenovirus type 5 (HAdV-5), showed strongly improved infection of both hMSCs and the HNSCC cell line UM-SCC-11B. Given that, we generated life cycle-unmodified and -modified replication-competent HAdV-5-HexPos3 vector variants and analyzed their replication within bone marrow- and adipose tissue-derived hMSCs. Efficient replication was detected for both life cycle-unmodified and -modified vectors. Moreover, we analyzed the migration of vector-carrying hMSCs toward different HNSCCs. Although migration of hMSCs to HNSCC cell lines was confirmed in vitro, no homing of hMSCs to HNSCC xenografts was observed in vivo in mice and in ovo in a chorioallantoic membrane model. Taken together, our data suggest that HAdV-5-HexPos3 is a potent candidate for hMSC-based oncolytic therapy of HNSCCs. However, it also emphasizes the importance of generating optimized in vivo models for the evaluation of hMSC as carrier cells.<\/jats:p>","DOI":"10.3390\/v15010218","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:05:52Z","timestamp":1673575552000},"page":"218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Human Mesenchymal Stromal Cells as Carriers for the Delivery of Oncolytic HAdV-5 to Head and Neck Squamous Cell Carcinomas"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-9547","authenticated-orcid":false,"given":"Robin","family":"Nilson","sequence":"first","affiliation":[{"name":"Department of Gene Therapy, University Medical Center Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-4131","authenticated-orcid":false,"given":"Lea","family":"Krutzke","sequence":"additional","affiliation":[{"name":"Department of Gene Therapy, University Medical Center Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Wienen","sequence":"additional","affiliation":[{"name":"Department of Gene Therapy, University Medical Center Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-0442","authenticated-orcid":false,"given":"Markus","family":"Rojewski","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University Medical Center Ulm, 89081 Ulm, Germany"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Donation Service, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Helge","family":"Zeplin","sequence":"additional","affiliation":[{"name":"Schlosspark Klinik Ludwigsburg, Privatklinik f\u00fcr Plastische und \u00c4sthetische Chirurgie, 71638 Ludwigsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Funk","sequence":"additional","affiliation":[{"name":"Sch\u00f6nheitsklinik Dr. Funk, 81739 M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schrezenmeier","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University Medical Center Ulm, 89081 Ulm, Germany"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Donation Service, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kochanek","sequence":"additional","affiliation":[{"name":"Department of Gene Therapy, University Medical Center Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Kritzinger","sequence":"additional","affiliation":[{"name":"Department of Gene Therapy, University Medical Center Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and Neck Squamous Cell Carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","unstructured":"(2022, October 26). Head and Neck Cancer: Statistics. Available online: https:\/\/www.cancer.net."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hamada, M., and Yura, Y. (2020). Efficient Delivery and Replication of Oncolytic Virus for Successful Treatment of Head and Neck Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197073"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ejca.2009.11.005","article-title":"Multimodal Approach Using Oncolytic Adenovirus, Cetuximab, Chemotherapy and Radiotherapy in HNSCC Low Passage Tumour Cell Cultures","volume":"46","author":"Dias","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.oraloncology.2016.02.014","article-title":"Oncolytic Adenoviruses Targeted to Human Papilloma Virus-Positive Head and Neck Squamous Cell Carcinomas","volume":"56","author":"LaRocca","year":"2016","journal-title":"Oral Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/cgt.2014.22","article-title":"Evaluation of Apoptogenic Adenovirus Type 5 Oncolytic Vectors in a Syrian Hamster Head and Neck Cancer Model","volume":"21","author":"Vijayalingam","year":"2014","journal-title":"Cancer Gene Ther."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Seiradake, E., Henaff, D., Wodrich, H., Billet, O., Perreau, M., Hippert, C., Mennechet, F., Schoehn, G., Lortat-Jacob, H., and Dreja, H. (2009). The Cell Adhesion Molecule \u201cCAR\u201d and Sialic Acid on Human Erythrocytes Influence Adenovirus in Vivo Biodistribution. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000277"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1182\/blood-2008-09-178459","article-title":"Human Erythrocytes Bind and Inactivate Type 5 Adenovirus by Presenting Coxsackie Virus-Adenovirus Receptor and Complement Receptor 1","volume":"113","author":"Carlisle","year":"2009","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm.3107","article-title":"Coagulation Factor X Shields Adenovirus Type 5 from Attack by Natural Antibodies and Complement","volume":"19","author":"Xu","year":"2013","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1128\/JVI.03217-14","article-title":"Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors","volume":"89","author":"Qiu","year":"2014","journal-title":"J. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/sj.gt.3301611","article-title":"Complement Activation by Recombinant Adenoviruses","volume":"8","author":"Cichon","year":"2001","journal-title":"Gene Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.vaccine.2009.10.145","article-title":"International Epidemiology of Human Pre-Existing Adenovirus (Ad) Type-5, Type-6, Type-26 and Type-36 Neutralizing Antibodies: Correlates of High Ad5 Titers and Implications for Potential HIV Vaccine Trials","volume":"28","author":"Mast","year":"2010","journal-title":"Vaccine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9568","DOI":"10.1128\/JVI.00663-07","article-title":"Targeting of Adenovirus Serotype 5 (Ad5) and 5\/47 Pseudotyped Vectors In Vivo: Fundamental Involvement of Coagulation Factors and Redundancy of CAR Binding by Ad5","volume":"81","author":"Waddington","year":"2007","journal-title":"J. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1128\/JVI.79.12.7478-7491.2005","article-title":"Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity","volume":"79","author":"Shayakhmetov","year":"2005","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1128\/JVI.05760-11","article-title":"Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors","volume":"86","author":"Khare","year":"2012","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/mt.2011.71","article-title":"Generation of a Kupffer Cell-Evading Adenovirus for Systemic and Liver-Directed Gene Transfer","volume":"19","author":"Khare","year":"2011","journal-title":"Mol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1021\/mp8000974","article-title":"Scavenger Receptor A: A New Route for Adenovirus 5","volume":"6","author":"Haisma","year":"2009","journal-title":"Mol. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"107586","DOI":"10.1016\/j.pharmthera.2020.107586","article-title":"Strategies for Enhancing Intratumoral Spread of Oncolytic Adenoviruses","volume":"213","author":"Goradel","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3389\/fimmu.2018.00866","article-title":"Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer","volume":"9","author":"Marelli","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e001684","DOI":"10.1136\/jitc-2020-001684","article-title":"Mesenchymal Stem Cells and Oncolytic Viruses: Joining Forces against Cancer","volume":"9","author":"Moreno","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.ymthe.2020.01.019","article-title":"First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors","volume":"28","author":"Ruano","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nilson, R., L\u00fcbbers, O., Wei\u00df, L., Singh, K., Scharffetter-Kochanek, K., Rojewski, M., Schrezenmeier, H., Zeplin, P.H., Funk, W., and Krutzke, L. (2021). Transduction Enhancers Enable Efficient Human Adenovirus Type 5-Mediated Gene Transfer into Human Multipotent Mesenchymal Stromal Cells. Viruses, 13.","DOI":"10.3390\/v13061136"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/sj.gt.3300941","article-title":"Insertion of an RGD Motif into the HI Loop of Adenovirus Fiber Protein Alters the Distribution of Transgene Expression of the Systemically Administered Vector","volume":"6","author":"Reynolds","year":"1999","journal-title":"Gene Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3615729","DOI":"10.1155\/2017\/3615729","article-title":"Human Menstrual Blood-Derived Mesenchymal Stem Cells as Potential Cell Carriers for Oncolytic Adenovirus","volume":"2017","author":"Moreno","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/ijc.29442","article-title":"Engineered Adenoviruses Combine Enhanced Oncolysis with Improved Virus Production by Mesenchymal Stromal Carrier Cells","volume":"137","author":"Hammer","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 Is a Receptor for Adenovirus Serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1128\/JVI.78.9.4454-4462.2004","article-title":"The Human Membrane Cofactor CD46 Is a Receptor for Species B Adenovirus Serotype 3","volume":"78","author":"Sirena","year":"2004","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.omtm.2022.03.004","article-title":"Hexon Modification of Human Adenovirus Type 5 Vectors Enables Efficient Transduction of Human Multipotent Mesenchymal Stromal Cells","volume":"25","author":"Nilson","year":"2022","journal-title":"Mol. Ther.-Methods Clin. Dev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1089\/104303400750001417","article-title":"Efficient Transformation of Primary Human Amniocytes by E1 Functions of Ad5: Generation of New Cell Lines for Adenoviral Vector Production","volume":"11","author":"Schiedner","year":"2000","journal-title":"Hum. Gene Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3109\/14653249.2012.655420","article-title":"Platelet Lysate from Whole Blood-Derived Pooled Platelet Concentrates and Apheresis-Derived Platelet Concentrates for the Isolation and Expansion of Human Bone Marrow Mesenchymal Stromal Cells: Production Process, Content and Identification of Active Components","volume":"14","author":"Fekete","year":"2012","journal-title":"Cytotherapy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jcyt.2019.03.001","article-title":"Translation of a Standardized Manufacturing Protocol for Mesenchymal Stromal Cells: A Systematic Comparison of Validation and Manufacturing Data","volume":"21","author":"Rojewski","year":"2019","journal-title":"Cytotherapy"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal Criteria for Defining Multipotent Mesenchymal Stromal Cells. The International Society for Cellular Therapy Position Statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcyt.2013.02.006","article-title":"Stromal Cells from the Adipose Tissue-Derived Stromal Vascular Fraction and Culture Expanded Adipose Tissue-Derived Stromal\/Stem Cells: A Joint Statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)","volume":"15","author":"Bourin","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.onc.1203251","article-title":"A Mutant Oncolytic Adenovirus Targeting the Rb Pathway Produces Anti-Glioma Effect in Vivo","volume":"19","author":"Fueyo","year":"2000","journal-title":"Oncogene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ymthe.2004.03.017","article-title":"An E1B-19 KDa Gene Deletion Mutant Adenovirus Demonstrates Tumor Necrosis Factor-Enhanced Cancer Selectivity and Enhanced Oncolytic Potency","volume":"9","author":"Liu","year":"2004","journal-title":"Mol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/JVI.74.6.2804-2813.2000","article-title":"Identification of Contact Residues and Definition of the CAR-Binding Site of Adenovirus Type 5 Fiber Protein","volume":"74","author":"Kirby","year":"2000","journal-title":"J. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1128\/jvi.70.11.7498-7509.1996","article-title":"Evaluation of the Concentration and Bioactivity of Adenovirus Vectors for Gene Therapy","volume":"70","author":"Mittereder","year":"1996","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/elps.1150080203","article-title":"Improved Silver Staining of Plant Proteins, RNA and DNA in Polyacrylamide Gels","volume":"8","author":"Blum","year":"1987","journal-title":"Electrophoresis"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1089\/hum.2020.045","article-title":"Chorioallantoic Membrane Tumor Model for Evaluating Oncolytic Viruses","volume":"31","author":"Krutzke","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"ref_41","unstructured":"Sauthoff, H., Heitner, S., Rom, W.N., and Hay, J.G. (2022, July 06). Deletion of the Adenoviral E1b-19kD Gene Enhances Tumor Cell Killing of a Replicating Adenoviral Vector. Available online: https:\/\/www.liebertpub.com\/doi\/10.1089\/10430340050015851."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1128\/JVI.80.4.2000-2012.2006","article-title":"Genetic Identification of Adenovirus Type 5 Genes That Influence Viral Spread","volume":"80","author":"Subramanian","year":"2006","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1158\/1078-0432.CCR-08-2008","article-title":"Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-Induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In Vivo","volume":"15","author":"Leitner","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.virol.2009.09.030","article-title":"Transgene Expression by Oncolytic Adenoviruses Is Modulated by E1B19K Deletion in a Cell Type-Dependent Manner","volume":"395","author":"Rohmer","year":"2009","journal-title":"Virology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1128\/jvi.68.10.6553-6566.1994","article-title":"Functional Complementation of the Adenovirus E1B 19-Kilodalton Protein with Bcl-2 in the Inhibition of Apoptosis in Infected Cells","volume":"68","author":"Chiou","year":"1994","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/sj.onc.1201323","article-title":"The E1B 19K Protein Associates with Lamins in Vivo and Its Proper Localization Is Required for Inhibition of Apoptosis","volume":"15","author":"Rao","year":"1997","journal-title":"Oncogene"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1078\/0171-9335-00282","article-title":"Partial Cleavage of A-Type Lamins Concurs with Their Total Disintegration from the Nuclear Lamina during Apoptosis","volume":"81","author":"Broers","year":"2002","journal-title":"Eur. J. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/1873-3468.13848","article-title":"The Adenovirus Death Protein\u2014A Small Membrane Protein Controls Cell Lysis and Disease","volume":"594","author":"Georgi","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1089\/hum.2007.034","article-title":"Human Mesenchymal Stem Cells Lack Tumor Tropism but Enhance the Antitumor Activity of Oncolytic Adenoviruses in Orthotopic Lung and Breast Tumors","volume":"18","author":"Hakkarainen","year":"2007","journal-title":"Hum. Gene Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1476-4598-10-134","article-title":"Mesenchymal Stem Cells as Carriers and Amplifiers in CRAd Delivery to Tumors","volume":"10","author":"Xia","year":"2011","journal-title":"Mol. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1158\/1535-7163.MCT-18-0431","article-title":"Enhanced Antitumor Efficacy of Oncolytic Adenovirus\u2013Loaded Menstrual Blood\u2013Derived Mesenchymal Stem Cells in Combination with Peripheral Blood Mononuclear Cells","volume":"18","author":"Moreno","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.ijrobp.2008.06.1953","article-title":"Radiation Increases Invasion of Gene-Modified Mesenchymal Stem Cells into Tumors","volume":"75","author":"Zielske","year":"2009","journal-title":"Int. J. Radiat. Oncol. *Biol. *Phys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00262-018-2220-2","article-title":"Antitumor Virotherapy Using Syngeneic or Allogeneic Mesenchymal Stem Cell Carriers Induces Systemic Immune Response and Intratumoral Leukocyte Infiltration in Mice","volume":"67","author":"Gambera","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9046","DOI":"10.18632\/oncotarget.7031","article-title":"Delivery of Improved Oncolytic Adenoviruses by Mesenchymal Stromal Cells for Elimination of Tumorigenic Pancreatic Cancer Cells","volume":"7","author":"Kaczorowski","year":"2016","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4252\/wjsc.v8.i3.73","article-title":"Homing and Migration of Mesenchymal Stromal Cells: How to Improve the Efficacy of Cell Therapy?","volume":"8","author":"Riet","year":"2016","journal-title":"World J. Stem Cells"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1182\/blood-2002-06-1830","article-title":"Mesenchymal Stem Cells Distribute to a Wide Range of Tissues Following Systemic Infusion into Nonhuman Primates","volume":"101","author":"Devine","year":"2003","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(03)14232-8","article-title":"Effect of Stromal-Cell-Derived Factor 1 on Stem-Cell Homing and Tissue Regeneration in Ischaemic Cardiomyopathy","volume":"362","author":"Askari","year":"2003","journal-title":"Lancet"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1161\/01.CIR.0000147780.30124.CF","article-title":"Stromal Cell-Derived Factor-1alpha Plays a Critical Role in Stem Cell Recruitment to the Heart after Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury","volume":"110","author":"Abbott","year":"2004","journal-title":"Circulation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3324\/haematol.10669","article-title":"Regulation of CXCR4 Expression in Human Mesenchymal Stem Cells by Cytokine Treatment: Role in Homing Efficiency in NOD\/SCID Mice","volume":"92","author":"Shi","year":"2007","journal-title":"Haematologica"},{"key":"ref_60","first-page":"1331","article-title":"Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells","volume":"36","author":"Sun","year":"2015","journal-title":"CPB"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1074\/jbc.M114.605063","article-title":"CXCR4 Receptor Overexpression in Mesenchymal Stem Cells Facilitates Treatment of Acute Lung Injury in Rats","volume":"290","author":"Yang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41571-018-0007-1","article-title":"Targeting the Tumour Stroma to Improve Cancer Therapy","volume":"15","author":"Valkenburg","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fonc.2020.00188","article-title":"Tumor-Associated Macrophages: Recent Insights and Therapies","volume":"10","author":"Zhou","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3389\/fonc.2019.01146","article-title":"Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy","volume":"9","author":"Masucci","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"106939","DOI":"10.1016\/j.intimp.2020.106939","article-title":"Effects of Immune Cells and Cytokines on Inflammation and Immunosuppression in the Tumor Microenvironment","volume":"88","author":"Li","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bertzbach, L.D., Ip, W.-H., and Dobner, T. (2021). Animal Models in Human Adenovirus Research. Biology, 10.","DOI":"10.3390\/biology10121253"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/1\/218\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:04:58Z","timestamp":1760119498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/1\/218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["v15010218"],"URL":"https:\/\/doi.org\/10.3390\/v15010218","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]}}}