{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:59:57Z","timestamp":1783792797836,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut National de la Recherche pour l\u2019agriculture","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}]},{"name":"Institut National de la Recherche pour l\u2019agriculture","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}]},{"name":"Institut National de la Recherche pour l\u2019agriculture","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}]},{"name":"l\u2019alimentation et l\u2019environnement","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}]},{"name":"l\u2019alimentation et l\u2019environnement","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}]},{"name":"l\u2019alimentation et l\u2019environnement","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}]},{"name":"the Ecole Pratique des Hautes Etudes","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}]},{"name":"the Ecole Pratique des Hautes Etudes","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}]},{"name":"the Ecole Pratique des Hautes Etudes","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}]},{"name":"the University of Lyon 1","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}]},{"name":"the University of Lyon 1","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}]},{"name":"the University of Lyon 1","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}]},{"name":"ANRS","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}]},{"name":"ANRS","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}]},{"name":"ANRS","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["AO-2019-1"],"award-info":[{"award-number":["AO-2019-1"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["AO-2021-1"],"award-info":[{"award-number":["AO-2021-1"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-20-CE15-0025-01"],"award-info":[{"award-number":["ANR-20-CE15-0025-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Rift Valley Fever virus (RVFV) and Toscana virus (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans and animals; as such, they represent a growing threat to public and veterinary health. Interferon-induced transmembrane (IFITM) proteins are broad inhibitors of a large panel of viruses belonging to various families and genera. However, little is known on the interplay between RVFV, TOSV, and the IFITM proteins derived from their naturally infected host species. In this study, we investigated the ability of human, bovine, and camel IFITMs to restrict RVFV and TOSV infection. Our results indicated that TOSV was extremely sensitive to inhibition by all the animal IFITMs tested, while RVFV was inhibited by human IFITM-2 and IFITM-3, but not IFITM-1, and exhibited a more heterogeneous resistance phenotype towards the individual bovine and camel IFITMs tested. Overall, our findings shed some light on the complex and differential interplay between two zoonotic viruses and IFITMs from their naturally infected animal species.<\/jats:p>","DOI":"10.3390\/v15020306","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T03:26:41Z","timestamp":1674444401000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["IFITMs from Naturally Infected Animal Species Exhibit Distinct Restriction Capacities against Toscana and Rift Valley Fever Viruses"],"prefix":"10.3390","volume":"15","author":[{"given":"Marie-Pierre","family":"Confort","sequence":"first","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00ebva","family":"Duboeuf","sequence":"additional","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Thiesson","sequence":"additional","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Pons","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Nationale Sup\u00e9rieure de Lyon, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-3997","authenticated-orcid":false,"given":"Federico","family":"Marziali","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Nationale Sup\u00e9rieure de Lyon, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Desloire","sequence":"additional","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-3549","authenticated-orcid":false,"given":"Maxime","family":"Ratinier","sequence":"additional","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cimarelli","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Nationale Sup\u00e9rieure de Lyon, F-69342 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-9848","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9rick","family":"Arnaud","sequence":"additional","affiliation":[{"name":"IVPC UMR754, INRAE, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1, EPHE, PSL University, F-69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"ref_1","first-page":"22","article-title":"Toscana virus epidemiology: From Italy to beyond","volume":"4","author":"Cusi","year":"2010","journal-title":"Open Virol. 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