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During this period, viral infections represent a risk to the mother, the placental unit, and the fetus. The Zika virus (ZIKV) outbreak in Brazil has been the cause of congenital Zika syndrome (CZS), with devastating consequences such as microcephaly in newborns. Herein, we analyzed the impact of maternal overweight\/obesity on the antiviral factors\u2019 expression in the placental tissue of Zika-infected mothers. We accessed placentas from women with and without obesity from 34 public health units (S\u00e3o Paulo) and from Zika-infected mothers with and without obesity from the Clinical Cohort Study of ZIKV pregnant women (Rio de Janeiro, Brazil). We first verified that obesity, without infection, did not alter the constitutive transcriptional expression of antiviral factors or IFN type I\/III expression. Interestingly, obesity, when associated with ZIKV infection, showed a decreased transcriptional expression of RIG-I and IFIH1 (MDA-5 protein precursor gene). At the protein level, we also verified a decreased RIG-I and IRF-3 expression in the decidual placenta from the Zika-infected obese group, regardless of microcephaly. This finding shows, for the first time, that obesity associated with ZIKV infection leads to an impaired type I IFN downstream signaling pathway in the maternal\u2013fetal interface.<\/jats:p>","DOI":"10.3390\/v15020320","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T01:29:45Z","timestamp":1674523785000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7861-6890","authenticated-orcid":false,"given":"Anna Cl\u00e1udia Calvielli Castelo","family":"Branco","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Dermatologia e Imunodefici\u00eancias (LIM56), Faculdade de Medicina, Instituto de Medicina Tropical, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas ICB, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily Araujo","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Dermatologia e Imunodefici\u00eancias (LIM56), Faculdade de Medicina, Instituto de Medicina Tropical, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas ICB, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1talli Zanete","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Dermatologia e Imunodefici\u00eancias (LIM56), Faculdade de Medicina, Instituto de Medicina Tropical, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-3306","authenticated-orcid":false,"given":"Ricardo Wesley","family":"Alberca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Dermatologia e Imunodefici\u00eancias (LIM56), Faculdade de Medicina, Instituto de Medicina Tropical, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-7186","authenticated-orcid":false,"given":"Amaro Nunes","family":"Duarte-Neto","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-6357","authenticated-orcid":false,"given":"Luiz Fernando Ferraz","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Guedes","family":"Luiz","sequence":"additional","affiliation":[{"name":"Instituto Pasteur, S\u00e3o Paulo 01311-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiura Vieira","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-7192","authenticated-orcid":false,"given":"Mirian Nacagami","family":"Sotto","sequence":"additional","affiliation":[{"name":"Departamento de Dermatologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiara Naiana","family":"Dejani","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Fisiologia e Patologia, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-6393","authenticated-orcid":false,"given":"Patr\u00edcia Helen Carvalho","family":"Rond\u00f3","sequence":"additional","affiliation":[{"name":"Departamento de Nutri\u00e7\u00e3o, Faculdade de Sa\u00fade P\u00fablica FSP, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-904, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyzabeth","family":"Avvad-Portari","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Funda\u00e7\u00e3o Oswaldo Cruz FIOCRUZ, Rio de Janeiro 22250-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-2224","authenticated-orcid":false,"given":"Zilton Farias Meira","family":"De Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Funda\u00e7\u00e3o Oswaldo Cruz FIOCRUZ, Rio de Janeiro 22250-020, 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Pharmaceuticals, 14.","DOI":"10.3390\/ph14111178"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/2\/320\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:14:07Z","timestamp":1760120047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/2\/320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,23]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["v15020320"],"URL":"https:\/\/doi.org\/10.3390\/v15020320","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,23]]}}}