{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:10:25Z","timestamp":1790701825857,"version":"4.1.0"},"reference-count":144,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research","award":["PJT-173318"],"award-info":[{"award-number":["PJT-173318"]}]},{"name":"Canadian Institutes of Health Research","award":["MM1-174898"],"award-info":[{"award-number":["MM1-174898"]}]},{"name":"Canadian Institutes of Health Research","award":["RGPIN-2022-02979"],"award-info":[{"award-number":["RGPIN-2022-02979"]}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["PJT-173318"],"award-info":[{"award-number":["PJT-173318"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["MM1-174898"],"award-info":[{"award-number":["MM1-174898"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council","doi-asserted-by":"publisher","award":["RGPIN-2022-02979"],"award-info":[{"award-number":["RGPIN-2022-02979"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Michael Smith Health Research BC, the St. Paul\u2019s Foundation","award":["PJT-173318"],"award-info":[{"award-number":["PJT-173318"]}]},{"name":"Michael Smith Health Research BC, the St. Paul\u2019s Foundation","award":["MM1-174898"],"award-info":[{"award-number":["MM1-174898"]}]},{"name":"Michael Smith Health Research BC, the St. Paul\u2019s Foundation","award":["RGPIN-2022-02979"],"award-info":[{"award-number":["RGPIN-2022-02979"]}]},{"name":"Center for Heart Lung Innovation","award":["PJT-173318"],"award-info":[{"award-number":["PJT-173318"]}]},{"name":"Center for Heart Lung Innovation","award":["MM1-174898"],"award-info":[{"award-number":["MM1-174898"]}]},{"name":"Center for Heart Lung Innovation","award":["RGPIN-2022-02979"],"award-info":[{"award-number":["RGPIN-2022-02979"]}]},{"name":"University of British Columbia","award":["PJT-173318"],"award-info":[{"award-number":["PJT-173318"]}]},{"name":"University of British Columbia","award":["MM1-174898"],"award-info":[{"award-number":["MM1-174898"]}]},{"name":"University of British Columbia","award":["RGPIN-2022-02979"],"award-info":[{"award-number":["RGPIN-2022-02979"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The myocardium\/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume. As the resident \u201cpowerhouse\u201d of cells, mitochondria help to fuel the high energy demands of a continuously beating myocardium. It is no surprise that mitochondrial dysfunction underscores the pathogenesis of many cardiovascular ailments, including those of viral origin such as virus-induced myocarditis. Enteroviruses have been especially linked to injuries of the myocardium and its sequelae dilated cardiomyopathy for which no effective therapies currently exist. Intriguingly, recent mechanistic insights have demonstrated viral infections to directly damage mitochondria, impair the mitochondrial quality control processes of the cell, such as disrupting mitochondrial antiviral innate immune signaling, and promoting mitochondrial-dependent pathological inflammation of the infected myocardium. In this review, we briefly highlight recent insights on the virus-mitochondria crosstalk and discuss the therapeutic implications of targeting mitochondria to preserve heart function and ultimately combat viral myocarditis.<\/jats:p>","DOI":"10.3390\/v15020351","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T01:58:59Z","timestamp":1674784739000},"page":"351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Mitochondria Dysfunction at the Heart of Viral Myocarditis: Mechanistic Insights and Therapeutic Implications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-2070","authenticated-orcid":false,"given":"Yasir","family":"Mohamud","sequence":"first","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-9466","authenticated-orcid":false,"given":"Boaz","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Bahreyni","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-7840","authenticated-orcid":false,"given":"Honglin","family":"Luo","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital, Vancouver, BC V6Z 1Y6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMra0800028","article-title":"Myocarditis","volume":"360","author":"Cooper","year":"2009","journal-title":"N. 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