{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:47:32Z","timestamp":1791474452182,"version":"4.3.4"},"reference-count":170,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"F.R.S.-FNRS","award":["PDR\/OL T.0067.21"],"award-info":[{"award-number":["PDR\/OL T.0067.21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Gammaherpesviruses (\u03b3HVs) include viruses that can induce lymphoproliferative diseases and tumors. These viruses can persist in the long term in the absence of any pathological manifestation in their natural host. Alcelaphine gammaherpesvirus 1 (AlHV-1) belongs to the genus Macavirus and asymptomatically infects its natural host, the wildebeest (Connochaetes spp.). However, when transmitted to several susceptible species belonging to the order Artiodactyla, AlHV-1 is responsible for the induction of a lethal lymphoproliferative disease, named wildebeest-derived malignant catarrhal fever (WD-MCF). Understanding the pathogenic mechanisms responsible for the induction of WD-MCF is important to better control the risks of transmission and disease development in susceptible species. The aim of this review is to synthesize the current knowledge on WD-MCF with a particular focus on the mechanisms by which AlHV-1 induces the disease. We discuss the potential mechanisms of pathogenesis from viral entry into the host to the maintenance of viral genomes in infected CD8+ T lymphocytes, and we present current hypotheses to explain how AlHV-1 infection induces a peripheral T cell lymphoma-like disease.<\/jats:p>","DOI":"10.3390\/v15020526","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:41:56Z","timestamp":1676342516000},"page":"526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Wildebeest-Derived Malignant Catarrhal Fever: A Bovine Peripheral T Cell Lymphoma Caused by Cross-Species Transmission of Alcelaphine Gammaherpesvirus 1"],"prefix":"10.3390","volume":"15","author":[{"given":"Meijiao","family":"Gong","sequence":"first","affiliation":[{"name":"Laboratory of Immunology-Vaccinology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"},{"name":"Laboratory of Parasitology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Myster","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology-Vaccinology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"van Campe","sequence":"additional","affiliation":[{"name":"Sciensano, Scientific Directorate Infectious Diseases in Animals, Experimental Center Machelen, Kerklaan 68, B-1830 Machelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Roels","sequence":"additional","affiliation":[{"name":"Sciensano, Scientific Directorate Infectious Diseases in Animals, Experimental Center Machelen, Kerklaan 68, B-1830 Machelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mostin","sequence":"additional","affiliation":[{"name":"Sciensano, Scientific Directorate Infectious Diseases in Animals, Experimental Center Machelen, Kerklaan 68, B-1830 Machelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Sciensano, Scientific Directorate Infectious Diseases in Animals, Experimental Center Machelen, Kerklaan 68, B-1830 Machelen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Vanderplasschen","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology-Vaccinology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-0799","authenticated-orcid":false,"given":"Benjamin G.","family":"Dewals","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology-Vaccinology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"},{"name":"Laboratory of Parasitology, Faculty of Veterinary Medicine, FARAH, ULi\u00e8ge, Avenue de Cureghem 10, B-4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"ref_1","unstructured":"Mettam, R.W.M. 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