{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:01:58Z","timestamp":1792807318636,"version":"4.5.0"},"reference-count":254,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kazan Federal University Strategic Academic Leadership Program","award":["PRIORITY-2030"],"award-info":[{"award-number":["PRIORITY-2030"]}],"id":[{"id":"https:\/\/ror.org\/05256ym39","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols. Orthohantavirus infection may cause Hemorrhagic Fever with Renal Syndrome (HRFS), a disease that is characterized by acute kidney injury and increased vascular permeability. Several species of orthohantaviruses were identified as causing infection, where Hantaan, Puumala, and Seoul viruses are most common. Orthohantaviruses are endemic to several Asian countries, such as China, South Korea, and Japan. Along with those countries, HFRS tops the list of zoonotic infections in the Far Eastern Federal District of Russia. Recently, orthohantavirus circulation was demonstrated in small mammals in Thailand and India, where orthohantavirus was not believed to be endemic. In this review, we summarized the current data on orthohantaviruses in Asia. We gave the synopsis of the history and diversity of orthohantaviruses in Asia. We also described the clinical presentation and current understanding of the pathogenesis of orthohantavirus infection. Additionally, conventional and novel approaches for preventing and treating orthohantavirus infection are discussed.<\/jats:p>","DOI":"10.3390\/v15020561","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T04:58:23Z","timestamp":1676869103000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention"],"prefix":"10.3390","volume":"15","author":[{"given":"Ayushi","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanya","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Sahay","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Martynova","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-5739","authenticated-orcid":false,"given":"Albert","family":"Rizvanov","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-9346","authenticated-orcid":false,"given":"Manoj","family":"Baranwal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Chandy","sequence":"additional","affiliation":[{"name":"Childs Trust Medical Research Foundation, Kanchi Kamakoti Childs Trust Hospital, Chennai 600034, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Khaiboullina","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-8190","authenticated-orcid":false,"given":"Emmanuel","family":"Kabwe","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"},{"name":"Kazan Research Institute of Epidemiology and Microbiology, Kazan 420012, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-2942","authenticated-orcid":false,"given":"Yuriy","family":"Davidyuk","sequence":"additional","affiliation":[{"name":"OpenLab \u201cGene and Cell Technologies\u201d, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref_1","unstructured":"(2022, August 08). 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