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In this article, antiviral drugs and the mechanisms of their action are summarized at the beginning as a prerequisite background to develop relevant drug delivery\/carrier systems for them, classified and briefly discussed subsequently. Many of the recent studies aim at different types of synthetic, semisynthetic, and natural polymers serving as a favorable matrix for the antiviral drug carrier. Besides a wider view of different antiviral delivery systems, this review focuses on advances in antiviral drug delivery systems based on chitosan (CS) and derivatized CS carriers. CS and its derivatives are evaluated concerning methods of their preparation, their basic characteristics and properties, approaches to the incorporation of an antiviral drug in the CS polymer as well as CS nanoparticulate systems, and their recent biomedical applications in the context of actual antiviral therapy. The degree of development (i.e., research study, in vitro\/ex vivo\/in vivo preclinical testing), as well as benefits and limitations of CS polymer and CS nanoparticulate drug delivery systems, are reported for particular viral diseases and corresponding antivirotics.<\/jats:p>","DOI":"10.3390\/v15030647","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:09:52Z","timestamp":1677564592000},"page":"647","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers"],"prefix":"10.3390","volume":"15","author":[{"given":"Dominika","family":"\u017digrayov\u00e1","sequence":"first","affiliation":[{"name":"Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University Bratislava, Odboj\u00e1rov 10, 83232 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Miku\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University Bratislava, Odboj\u00e1rov 10, 83232 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-9970","authenticated-orcid":false,"given":"Peter","family":"Miku\u0161","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University Bratislava, Odboj\u00e1rov 10, 83232 Bratislava, Slovakia"},{"name":"Toxicological and Antidoping Center, Faculty of Pharmacy, Comenius University Bratislava, Odboj\u00e1rov 10, 83232 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2217\/17460794.4.2.101","article-title":"Advances in antiviral drug discovery and development: Part I: Advancements in antiviral drug discovery","volume":"4","author":"Saxena","year":"2009","journal-title":"Future Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ijbiomac.2021.01.076","article-title":"Trends and strategies to combat viral infections: A review on FDA approved antiviral drugs","volume":"172","author":"Tompa","year":"2021","journal-title":"Int. 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