{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:20:25Z","timestamp":1791854425545,"version":"4.3.4"},"reference-count":112,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Viruses account for 80% of all cases of acute conjunctivitis and adenovirus; enterovirus and herpes virus are the common causative agents. In general, viral conjunctivitis spreads easily. Therefore, to control the spread, it is crucial to quickly diagnose illnesses, strictly implement hand washing laws, and sanitize surfaces. Swelling of the lid margin and ciliary injection are subjective symptoms, and eye discharge is frequently serofibrinous. Preauricular lymph node swelling can occasionally occur. Approximately 80% of cases of viral conjunctivitis are caused by adenoviruses. Adenoviral conjunctivitis may become a big global concern and may cause a pandemic. Diagnosis of herpes simplex viral conjunctivitis is crucial for using corticosteroid eye solution as a treatment for adenovirus conjunctivitis. Although specific treatments are not always accessible, early diagnosis of viral conjunctivitis may help to alleviate short-term symptoms and avoid long-term consequences.<\/jats:p>","DOI":"10.3390\/v15030676","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T05:18:43Z","timestamp":1678079923000},"page":"676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Viral Conjunctivitis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-9254","authenticated-orcid":false,"given":"Tetsuaya","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan"},{"name":"Imaizumi Eye Hospital, Koriyama 963-8877, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Imaizumi Eye Hospital, Koriyama 963-8877, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koju","family":"Kamoi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Tokyo Medical Dental University, Tokyo 113-8519, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e000476","DOI":"10.1136\/bmjophth-2020-000476","article-title":"Personal hygiene risk factors for contact lens-related microbial keratitis","volume":"5","author":"Stellwagen","year":"2020","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.clae.2019.07.001","article-title":"Viral conjunctivitis: A retrospective study in an Australian hospital","volume":"42","author":"Marinos","year":"2019","journal-title":"Cont Lens Anterior Eye"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000086110","article-title":"Ocular findings in Japanese patients with varicella-zoster virus infection","volume":"219","author":"Yoshida","year":"2005","journal-title":"Ophthalmologica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16049","DOI":"10.1038\/nrdp.2016.49","article-title":"Measles","volume":"2","author":"Rota","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/00365540410022648","article-title":"A case of mumps conjunctivitis: Detection of the virus RNA by nested PCR in tear sample","volume":"36","author":"Kalkan","year":"2004","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/0002-9394(74)90819-8","article-title":"Mumps conjunctivitis","volume":"78","author":"Meyer","year":"1974","journal-title":"Am. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jama.2013.280318","article-title":"Conjunctivitis: A systematic review of diagnosis and treatment","volume":"310","author":"Azari","year":"2013","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/02713683.2021.2009518","article-title":"Herpes simplex virus 2 blepharokeratoconjunctivitis","volume":"47","author":"Yadav","year":"2022","journal-title":"Curr. Eye Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajo.2021.02.002","article-title":"Herpes zoster ophthalmicus clinical presentation and risk factors for loss of vision","volume":"226","author":"Niederer","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/bjo.2009.178772","article-title":"Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus","volume":"95","author":"Kaneko","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3181\/00379727-84-20714","article-title":"Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture","volume":"84","author":"Rowe","year":"1953","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bj.2021.08.009","article-title":"Human adenovirus infections in pediatric population\u2014An update on clinicoepathologic correlation","volume":"45","author":"Shieh","year":"2022","journal-title":"Biomed. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1126\/science.1187433","article-title":"Atomic structure of human adenovirus by cryoEM reveals interactions among protein networks","volume":"329","author":"Liu","year":"2010","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/QCO.0000000000000663","article-title":"Pediatric acute gastroenteritis associated with adenovirus 40\/41 in low-income and middle-income countries","volume":"33","author":"Lee","year":"2020","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s15010-020-01484-7","article-title":"Adenovirus diseases: A systematic review and meta-analysis of 228 case reports","volume":"49","author":"Gu","year":"2021","journal-title":"Infection"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1002\/1873-3468.13693","article-title":"Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D","volume":"593","author":"Ismail","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/jmv.24565","article-title":"Identification and molecular characterization of adenovirus types (HAdV-8, HAdV-37, HAdV-4, HAdV-3) in an epidemic of keratoconjunctivitis occurred in Pune, Maharashtra, Western India","volume":"88","author":"Gopalkrishna","year":"2016","journal-title":"J. Med. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100826","DOI":"10.1016\/j.preteyeres.2019.100826","article-title":"Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis","volume":"76","author":"Jonas","year":"2020","journal-title":"Prog. Retin Eye Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.7883\/yoken.JJID.2020.034","article-title":"Five cases of epidemic keratoconjunctivitis due to human adenovirus type 85 in Fukushima, Japan","volume":"73","author":"Kaneko","year":"2020","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jmv.21175","article-title":"Monitoring of adenovirus from conjunctival scrapings in Japan during 2005\u20132006","volume":"80","author":"Matsui","year":"2008","journal-title":"J. Med. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10384-021-00826-8","article-title":"Efficacy of compartmentalization in controlling an adenovirus type 54 keratoconjunctivitis outbreak on Oki Island, Japan","volume":"65","author":"Omatsu","year":"2021","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2147\/OPTH.S148264","article-title":"Clinical and virologcal analysis of epidemic keratoconjunctivitis caused by adenovirus type 54 in a regional ophthalmic clinic in Kyushu, Japan","volume":"12","author":"Umemura","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s10384-020-00727-2","article-title":"Characteristic of slow growth in cell culture of adenovirus type 54 causing nationwide outbreak epidemic keratoconjunctivitis in Japan","volume":"64","author":"Hanaoka","year":"2020","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10384-010-0894-x","article-title":"Clinical features of adenoviral conjunctivitis at the early stage of infection","volume":"55","author":"Aoki","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1185\/03007990903038269","article-title":"Acute conjunctivitis: Truth and misconceptions","volume":"25","author":"Jeng","year":"2009","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_26","first-page":"133","article-title":"Waterborne adenovirus","volume":"198","author":"Mena","year":"2009","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"ref_27","unstructured":"Liu, C. (1991). Belshe RB Ed., Mosby Year Book. [2nd ed.]. Textbook of human virology."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Evans, A.S., and Kaslow, R.A. (1997). Viral Infections of Humans: Epidemiology and Control, Plenum Publishing Corporation. [4th ed.].","DOI":"10.1007\/978-1-4899-0036-4"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3109\/09273948.2010.498658","article-title":"Cellular and tissue architecture of conjunctival membranes in epidemic keratoconjunctivitis","volume":"18","author":"Chintakuntlawar","year":"2010","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_30","first-page":"73","article-title":"Adenovirus: Ocular manifestations","volume":"33","author":"Hoffman","year":"2020","journal-title":"Community Eye Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.survophthal.2015.04.001","article-title":"Adenoviral keratoconjunctivitis","volume":"60","author":"Jhanji","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1755-3768.2007.01148.x","article-title":"Is it possible to detect the presence of adenovirus in conjunctiva before the onset of conjunctivitis?","volume":"87","author":"Kimura","year":"2009","journal-title":"Acta Ophthalmol."},{"key":"ref_33","first-page":"341","article-title":"The fate of corneal infiltrations in cases of epidemic keratoconjunctivitis. A follow-up study over two and a half years","volume":"88","author":"Freyler","year":"1976","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0161-6420(97)30145-6","article-title":"Rapid diagnosis of adeno-viral conjufictivitis on conjunctival swab by 10-minute immunochromatography","volume":"104","author":"Uchio","year":"1997","journal-title":"Ophthalmology"},{"key":"ref_35","first-page":"481","article-title":"Evaluation of adenovirus amplified detection kit using tears containing conjunctival exudate","volume":"72","author":"Ueno","year":"2018","journal-title":"Rinsho Ganka"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0886-3350(01)01112-9","article-title":"Reactivation of presumed adenoviral keratitis after laser in situ keratomileusis","volume":"28","author":"Safak","year":"2002","journal-title":"J. Cataract. Refract Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/jcm.6.3.257-265.1977","article-title":"New human adenovirus (candidate adenovirus type 35) causing fatal disseminated infection in a renal transplant recipient","volume":"6","author":"Stalder","year":"1977","journal-title":"J. Clin. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajo.2021.10.028","article-title":"Molecular and clinical characterization of human adenovirus E4-Associated conjunctivitis","volume":"233","author":"Akileswaran","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1556\/EuJMI.4.2014.1.2","article-title":"Human adenovirus: Viral pathogen with increasing importance","volume":"4","author":"Ghebremedhin","year":"2014","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"19125","DOI":"10.2807\/ese.14.08.19125-en","article-title":"A swimming pool-related outbreak of pharyngoconjunctival fever in children due to adenovirus type 4, Gipuzkoa, Spain, 2008","volume":"14","author":"Artieda","year":"2009","journal-title":"Eur. Surveill."},{"key":"ref_41","unstructured":"Centers for Disease Control (CDC) (1992). Outbreak of pharyngoconjunctival fever at a summer camp\u2014North Carolina, 1991. MMWR Morb. Mortal Wkly Rep., 41, 342\u2013344."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/bjo.54.9.628","article-title":"Unusual type of epidemic conjunctivitis in Ghana","volume":"54","author":"Chatterjee","year":"1970","journal-title":"Br. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/oxfordjournals.aje.a112106","article-title":"Apollo 11 disease or acute hemorrhagic conjunctivitis: A pandemic of a new enterovirus infection of the eyes","volume":"101","author":"Kono","year":"1975","journal-title":"Am. J. Epidemiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/eye.2009.8","article-title":"Molecular and immunocytochemical identification of coxsackievirus A-24 variant from the acute haemorrhagic conjunctivitis outbreak in Taiwan in 2007","volume":"24","author":"Kuo","year":"2010","journal-title":"Eye (Lond)"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/1348-0421.12141","article-title":"Molecular evolution of VP3, VP1, 3C(pro) and 3D(pol) coding regions in coxsackievirus group A type 24 variant isolates from acute hemorrhagic conjunctivitis in 2011 in Okinawa, Japan","volume":"58","author":"Nidaira","year":"2014","journal-title":"Microbiol. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Netanyah, E., Calafatti, M., Arvastsson, J., Cabrera-Rode, E., Cilio, C.M., and Sarmiento, L. (2020). Extracellular vesicles released by enterovirus-infected endoC-\u03b2H1 cells mediate non-lytic viral spread. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111753"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e01288-19","DOI":"10.1128\/JVI.01288-19","article-title":"Structure of the 5\u2019 untranslated region of enteroviral genomic RNA","volume":"93","author":"Mahmud","year":"2019","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15223","DOI":"10.1038\/srep15223","article-title":"Whole-Genome Sequence Analysis Reveals the Enterovirus D68 Isolates during the United States 2014 Outbreak Mainly Belong to a Novel Clade","volume":"5","author":"Huang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MOP.0000000000000303","article-title":"Enteroviruses in the early 21st century: New manifestations and challenges","volume":"28","author":"Lugo","year":"2016","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.3389\/fmicb.2020.01817","article-title":"Enterovirus replication organelles and inhibitors of their formation","volume":"11","author":"Li","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3201\/eid1405.071121","article-title":"Acute encephalitis caused by intrafamilial transmission of enterovirus 71 in adult","volume":"14","author":"Hamaguchi","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Joshi, Y.P., Kim, J.H., Kim, H., and Cheong, H.K. (2018). Impact of drinking water quality on the development of enteroviral diseases in Korea. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15112551"},{"key":"ref_53","first-page":"341","article-title":"Enterovirus type 70: The etiologic agent of pandemic acute haemorrhagic conjunctivitis","volume":"49","author":"Mirkovic","year":"1973","journal-title":"Bull. World Health Organ"},{"key":"ref_54","unstructured":"Centers for Disease Control and Prevention (CDC) (2004). Acute hemorrhagic conjunctivitis outbreak caused by Coxsackievirus A24--Puerto Rico, 2003. MMWR Morb. Mortal Wkly Rep., 53, 632\u2013634."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1743-422X-10-96","article-title":"A molecular investigative approach to an outbreak of acute hemorrhagic conjunctivitis in Egypt, October 2010","volume":"25","author":"Ayoub","year":"2013","journal-title":"Virol. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s004170050280","article-title":"An epidemic of acute haemorrhagic conjunctivitis caused by enterovirus 70 in Okinawa, Japan, in 1994","volume":"237","author":"Uchio","year":"1999","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1017\/S095026882000182X","article-title":"Forecasting the incidence of acute haemorrhagic conjunctivitis in Chongqing: A time series analysis","volume":"148","author":"Qiu","year":"2020","journal-title":"Epidemiol. Infect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.7883\/yoken1952.41.159","article-title":"The first epidemic of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant in Okinawa, Japan, in 1985\u20131986","volume":"41","author":"Miyamura","year":"1988","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"45202","DOI":"10.1038\/srep45202","article-title":"Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004\u20132014","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.2147\/OPTH.S275762","article-title":"Methylene blue inhibits acute hemorrhagic conjunctivitis virus production and induction of caspase-3 mediated human corneal cell cytopathy","volume":"23","author":"Langford","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_61","first-page":"3009589","article-title":"Epidemiological investigation and risk factor analysis of acute hemorrhagic conjunctivitis in Huangshi port district, Huangshi city","volume":"2022","author":"Liu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41598-019-56850-9","article-title":"Transmissibility of acute haemorrhagic conjunctivitis in small-scale outbreaks in Hunan Province, China","volume":"10","author":"Zhang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"a013011","DOI":"10.1101\/cshperspect.a013011","article-title":"Herpes simplex viruses: Mechanisms of DNA replication","volume":"4","author":"Weller","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"McElwee, M., Vijayakrishnan, S., Rixon, F., and Bhella, D. (2018). Structure of the herpes simplex virus portal-vertex. PLoS Biol., 16.","DOI":"10.1101\/290544"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1743-422X-8-481","article-title":"Herpes simplex virus infects most cell types in vitro: Clues to its success","volume":"8","author":"Karasneh","year":"2011","journal-title":"Virol. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00005072-199305000-00008","article-title":"Neuropathology of herpes simplex virus encephalitis in a rat seizure model","volume":"52","author":"Beers","year":"1993","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_67","first-page":"357","article-title":"The isolation of herpes simplex virus from rabbit corneas during latency","volume":"30","author":"Taylor","year":"1989","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/bjo.84.9.968","article-title":"Clinical and epidemiological features of acute follicular conjunctivitis with special reference to that caused by herpes simplex virus type 1","volume":"84","author":"Uchio","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref_69","first-page":"CD001211","article-title":"Antibiotics versus placebo for acute bacterial conjunctivitis","volume":"9","author":"Sheikh","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/NHH.0000000000000791","article-title":"Herpes simplex virus keratitis","volume":"37","author":"Harris","year":"2019","journal-title":"Home Health Now"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/ICU.0000000000000618","article-title":"Ocular manifestations of herpes simplex virus","volume":"30","author":"Valerio","year":"2019","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ajo.2021.03.020","article-title":"Distinguishing features of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus","volume":"227","author":"Terada","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/ICU.0b013e32834be021","article-title":"Viral anterior uveitis","volume":"22","author":"Jap","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/00099228221113407","article-title":"Acute retinal necrosis after HSV-2 encephalitis in a preterm neonate","volume":"62","author":"Jia","year":"2023","journal-title":"Clin. Pediatr. (Phila)"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000099275","article-title":"Acute retinal necrosis","volume":"92","author":"Kezuka","year":"2007","journal-title":"Chem. Immunol. Allergy"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/ICO.0000000000002613","article-title":"Herpes simplex virus-related conjunctivitis resistant to aciclovir: A Case Report and Review of the Literature","volume":"40","author":"Esra","year":"2021","journal-title":"Cornea"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrmicro3215","article-title":"Molecular mechanisms of varicella zoster virus pathogenesis","volume":"12","author":"Zerboni","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1089\/vim.2019.0090","article-title":"Mother-to-child transfer of reactivated varicella-zoster virus DNA and varicella-zoster IgG in pregnancy","volume":"33","author":"Ranjan","year":"2020","journal-title":"Viral Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Psichogiou, M., Samarkos, M., Mikos, N., and Hatzakis, A. (2021). Reactivation of varicella zoster virus after vaccination for SARS-CoV-2. Vaccines (Basel), 9.","DOI":"10.3390\/vaccines9060572"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00417-002-0609-1","article-title":"Prognostic value of Hutchinson\u2019s sign in acute herpes zoster ophthalmicus","volume":"241","author":"Zaal","year":"2003","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e243217","DOI":"10.1136\/bcr-2021-243217","article-title":"Varicella caused by airborne transmission of a localised herpes zoster infection in a family","volume":"14","author":"Hatsushika","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMcp1302674","article-title":"Clinical practice: Herpes zoster","volume":"369","author":"Cohen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.mayocp.2013.03.014","article-title":"Herpes zoster--eye complications: Rates and trends","volume":"88","author":"Yawn","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_85","unstructured":"Grayson, M. (1997). Grayson\u2019s Diseases of the Cornea, Mosby. [4th ed.]."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jdermsci.2018.09.006","article-title":"Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation","volume":"93","author":"Yamamoto","year":"2019","journal-title":"J. Derm. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e00184-18","DOI":"10.1128\/genomeA.00184-18","article-title":"Complete genome sequences of six measles virus strains","volume":"6","author":"Phan","year":"2018","journal-title":"Genome Announc."},{"key":"ref_88","first-page":"1523","article-title":"Ophthalmological symptoms of measles and their treatment","volume":"158","author":"Roth","year":"2017","journal-title":"Orv. Hetil."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Laksono, B.M., de Vries, R.D., McQuaid, S., Duprex, W.P., and de Swart, R.L. (2016). Measles virus host invasion and pathogenesis. Viruses, 8.","DOI":"10.3390\/v8080210"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2333794X211065330","DOI":"10.1177\/2333794X211065330","article-title":"Trends and treatment of sub-acute sclerosing panencephalitis: An updated review","volume":"21","author":"Memon","year":"2021","journal-title":"Glob. Pediatr. Health"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00006454-198407000-00019","article-title":"Ocular viral infections","volume":"3","author":"Matoba","year":"1984","journal-title":"Pediatr. Infect. Dis."},{"key":"ref_92","first-page":"1007","article-title":"Measles and eye complications","volume":"112","author":"McSwiney","year":"2019","journal-title":"Ir. Med. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4161\/hv.36165","article-title":"Viral etiology of mumps-like illnesses in suspected mumps cases reported in Catalonia, Spain","volume":"11","author":"Barrabeig","year":"2015","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/21645515.2020.1765619","article-title":"Close the gap for routine mumps vaccination in Japan","volume":"17","author":"Kitano","year":"2021","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/09273948.2012.747619","article-title":"A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR","volume":"21","author":"Ando","year":"2013","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1179\/146532805X23407","article-title":"Bilateral retrobulbar neuritis associated with mumps","volume":"25","author":"Gnananayagam","year":"2005","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0002-9394(02)01701-4","article-title":"A controlled trial of povidone-iodine to treat infectious conjunctivitis in children","volume":"134","author":"Isenberg","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/ICO.0000000000000247","article-title":"Tacrolimus for the treatment of subepithelial infiltrates resistant to topical steroids after adenoviral keratoconjunctivitis","volume":"33","author":"Ghanem","year":"2014","journal-title":"Cornea"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcv.2019.01.004","article-title":"Challenge in management of epidermic keratoconjunctivitis with emerging recombinant human adenoviruses","volume":"112","author":"Gonzalez","year":"2019","journal-title":"J. Clin. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajo.2018.05.012","article-title":"Randomized, controlled, phase 2 trial of Povidone-iodine\/dexamethasone ophthalmic suspension for treatment of adenoviral conjunctivitis","volume":"194","author":"Pepose","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10792-016-0260-1","article-title":"Ganciclovir ophthalmic gel treatment shortens the recovery time and prevents complications in the adenoviral eye infection","volume":"37","author":"Ozen","year":"2017","journal-title":"Int. Ophthalmol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0002-9394(02)01599-4","article-title":"Adenovirus detected by polymerase chain reaction in multidose eyedrop bottles used by patients with adenoviral keratoconjunctivitis","volume":"134","author":"Uchio","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0002-9394(01)01128-X","article-title":"The disinfection of contact lenses contaminated with adenovirus","volume":"132","author":"Kowalski","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/AAC.15.5.642","article-title":"Growth inhibition by acycloguanosine of herpesviruses isolated from human infections","volume":"15","author":"Crumpacker","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1073\/pnas.96.2.447","article-title":"The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of alpha-like DNA polymerases","volume":"96","author":"Huang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1016\/S0021-9258(17)42739-6","article-title":"Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase","volume":"259","author":"Furman","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00003226-198706040-00011","article-title":"Diagnosis and management of herpes simplex stromal keratitis","volume":"6","author":"Wilhelmus","year":"1987","journal-title":"Cornea"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajo.2022.01.010","article-title":"Acyclovir-resistant herpes simplex virus 1 keratitis: A concerning and emerging clinical challenge","volume":"238","author":"Rousseau","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jcv.2011.06.009","article-title":"Identification and characterization of acyclovir-resitant clinical HSV-1 isolates from children","volume":"52","author":"Wang","year":"2011","journal-title":"J. Clin. Virol."},{"key":"ref_110","first-page":"e478","article-title":"Improvement of acyclovir-resistant herpes zoster infection by amenamevir","volume":"48","author":"Onaka","year":"2021","journal-title":"J. Derm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/bjophthalmol-2012-302062","article-title":"Efficacy of herpes virus helicase-primase inhibitor, ASP2151, for treating herpes simplex keratitis in mouse model","volume":"97","author":"Sasaki","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/09273940590950927","article-title":"A rare ocular complication of mumps: Kerato-uveitis","volume":"13","author":"Onal","year":"2005","journal-title":"Ocul. Immunol. 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