{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:27:38Z","timestamp":1772807258948,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2021YFC2302003"],"award-info":[{"award-number":["2021YFC2302003"]}]},{"name":"National Key Research and Development Program of China","award":["L192014"],"award-info":[{"award-number":["L192014"]}]},{"name":"Natural Science Foundation of Beijing","award":["2021YFC2302003"],"award-info":[{"award-number":["2021YFC2302003"]}]},{"name":"Natural Science Foundation of Beijing","award":["L192014"],"award-info":[{"award-number":["L192014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In recent years, the prevalence of hand, foot, and mouth disease (HFMD) caused by enteroviruses other than enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16) has gradually increased. The throat swab specimens of 2701 HFMD cases were tested, the VP1 regions of CVA10 RNA were amplified using RT-PCR, and phylogenetic analysis of CVA10 was performed. Children aged 1\u20135 years accounted for the majority (81.65%) and boys were more than girls. The positivity rates of EV-A71, CVA16, and other EVs were 15.22% (219\/1439), 28.77% (414\/1439), and 56.01% (806\/1439), respectively. CVA10 is one of the important viruses of other EVs. A total of 52 CVA10 strains were used for phylogenetic analysis based on the VP1 region, 31 were from this study, and 21 were downloaded from GenBank. All CVA10 sequences could be assigned to seven genotypes (A, B, C, D, E, F, and G), and genotype C was further divided into C1 and C2 subtypes, only one belonged to subtype C1 and the remaining 30 belonged to C2 in this study. This study emphasized the importance of strengthening the surveillance of HFMD to understand the mechanisms of pathogen variation and evolution, and to provide a scientific basis for HFMD prevention, control, and vaccine development.<\/jats:p>","DOI":"10.3390\/v15030694","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T03:29:05Z","timestamp":1678246145000},"page":"694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epidemiology of Hand, Foot, and Mouth Disease and Genetic Evolutionary Characteristics of Coxsackievirus A10 in Taiyuan City, Shanxi Province from 2016 to 2020"],"prefix":"10.3390","volume":"15","author":[{"given":"Jitao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China"},{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Xu","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiane","family":"Guo","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihong","family":"Gao","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Zuo","sequence":"additional","affiliation":[{"name":"Taiyuan Center for Disease Control and Prevention, 89 Xinjian South Road, Taiyuan 030012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of Biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Lu","sequence":"additional","affiliation":[{"name":"WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of Biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-5437","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of Biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"},{"name":"Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.47102\/annals-acadmedsg.V32N3p381","article-title":"Clinical characteristics of an outbreak of hand, foot and mouth disease in Singapore","volume":"32","author":"Shah","year":"2003","journal-title":"Ann. 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Methods"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/3\/694\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:49:51Z","timestamp":1760122191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/3\/694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,7]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["v15030694"],"URL":"https:\/\/doi.org\/10.3390\/v15030694","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,7]]}}}