{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:15:51Z","timestamp":1793254551944,"version":"4.5.0"},"reference-count":245,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Grant Scheme","award":["FRGS\/1\/2020\/SKK06\/SYUC\/03\/1"],"award-info":[{"award-number":["FRGS\/1\/2020\/SKK06\/SYUC\/03\/1"]}]},{"name":"Centre for Virus and Vaccine Research (CVVR), School of Medical and Life Sciences, Sunway University","award":["FRGS\/1\/2020\/SKK06\/SYUC\/03\/1"],"award-info":[{"award-number":["FRGS\/1\/2020\/SKK06\/SYUC\/03\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue is a major global health threat causing 390 million dengue infections and 25,000 deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of a clinically approved antiviral against dengue virus (DENV) drive the urgent demand for the development of novel anti-DENV therapeutics. Various antiviral agents have been developed and investigated for their anti-DENV activities. This review discusses the mechanisms of action employed by various antiviral agents against DENV. The development of host-directed antivirals targeting host receptors and direct-acting antivirals targeting DENV structural and non-structural proteins are reviewed. In addition, the development of antivirals that target different stages during post-infection such as viral replication, viral maturation, and viral assembly are reviewed. Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections. Evaluations of combinations of antiviral drugs with different mechanisms of action could also lead to the development of synergistic drug combinations for the treatment of dengue at any stage of the infection.<\/jats:p>","DOI":"10.3390\/v15030705","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T02:33:16Z","timestamp":1678329196000},"page":"705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Molecular Mechanisms of Antiviral Agents against Dengue Virus"],"prefix":"10.3390","volume":"15","author":[{"given":"Michelle Felicia","family":"Lee","sequence":"first","affiliation":[{"name":"Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, Bandar Sunway 47500, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Seng","family":"Wu","sequence":"additional","affiliation":[{"name":"Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, Bandar Sunway 47500, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-6291","authenticated-orcid":false,"given":"Chit Laa","family":"Poh","sequence":"additional","affiliation":[{"name":"Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, No. 5, Jalan Universiti, Bandar Sunway 47500, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mitra, A.K., and Mawson, A.R. (2017). Neglected Tropical Diseases: Epidemiology and Global Burden. Trop. Med. Infect. Dis., 2.","DOI":"10.3390\/tropicalmed2030036"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e08347","DOI":"10.7554\/eLife.08347","article-title":"The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus","volume":"4","author":"Kraemer","year":"2015","journal-title":"eLife"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Obi, J.O., Guti\u00e9rrez-Barbosa, H., Chua, J.V., and Deredge, D.J. (2021). Current Trends and Limitations in Dengue Antiviral Research. Trop. Med. Infect. Dis., 6.","DOI":"10.20944\/preprints202108.0364.v1"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Montoya, M., Gresh, L., Mercado, J.C., Williams, K.L., Vargas, M.J., Gutierrez, G., Kuan, G., Gordon, A., Balmaseda, A., and Harris, E. (2013). Symptomatic Versus Inapparent Outcome in Repeat Dengue Virus Infections Is Influenced by the Time Interval between Infections and Study Year. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002357"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4269\/ajtmh.14-0132","article-title":"Research on Dengue During World War II Revisited","volume":"91","author":"Snow","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29201","DOI":"10.1038\/srep29201","article-title":"Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses","volume":"6","author":"Flipse","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1128\/JVI.01826-10","article-title":"An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection","volume":"85","author":"Midgley","year":"2011","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.1073\/pnas.1306333110","article-title":"Original antigenic sin in dengue revisited","volume":"110","author":"Zompi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/003335491212700305","article-title":"Return of Epidemic Dengue in the United States: Implications for the Public Health Practitioner","volume":"127","author":"Bouri","year":"2012","journal-title":"Public Health Rep."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Frentiu, F.D., Zakir, T., Walker, T., Popovici, J., Pyke, A.T., Hurk, A.V.D., McGraw, E.A., and O\u2019Neill, S.L. (2014). Limited Dengue Virus Replication in Field-Collected Aedes aegypti Mosquitoes Infected with Wolbachia. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002688"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Phuc, H.K., Andreasen, M.H., Burton, R.S., Vass, C., Epton, M.J., Pape, G., Fu, G., Condon, K.C., Scaife, S., and Donnelly, C.A. (2007). Late-acting dominant lethal genetic systems and mosquito control. BMC Biol., 5.","DOI":"10.1186\/1741-7007-5-11"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(14)61060-6","article-title":"Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: A phase 3, randomised, observer-masked, placebo-controlled trial","volume":"384","author":"Capeding","year":"2014","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","volume":"373","author":"Hadinegoro","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJMoa1411037","article-title":"Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America","volume":"372","author":"Villar","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.antiviral.2013.09.013","article-title":"Ten years of dengue drug discovery: Progress and prospects","volume":"100","author":"Lim","year":"2013","journal-title":"Antivir. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S1473-3099(14)70730-3","article-title":"Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): A phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial","volume":"14","author":"Low","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/cid\/cis655","article-title":"Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial","volume":"55","author":"Tam","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tricou, V., Minh, N.N., Van, T.P., Lee, S.J., Farrar, J., Wills, B., Tran, H.T., and Simmons, C.P. (2010). A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000785"},{"key":"ref_20","first-page":"468","article-title":"Lovastatin for the Treatment of Adult Patients with Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"62","author":"Whitehorn","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/JVI.72.1.73-83.1998","article-title":"Phylogeny of the Genus Flavivirus","volume":"72","author":"Kuno","year":"1998","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1073\/pnas.0832193100","article-title":"A ligand-binding pocket in the dengue virus envelope glycoprotein","volume":"100","author":"Modis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","first-page":"55","article-title":"Role of the dengue virus 5\u2032 and 3\u2032 untranslated regions in viral replication","volume":"Volume 1","author":"Hanley","year":"2010","journal-title":"Frontiers in Dengue Virus Research"},{"key":"ref_24","first-page":"14","article-title":"Translation and processing of the dengue virus polyprotein","volume":"Volume 1","author":"Hanley","year":"2010","journal-title":"Frontiers in Dengue Virus Research"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ng, W.C., Soto-Acosta, R., Bradrick, S.S., Garcia-Blanco, M.A., and Ooi, E.E. (2017). The 5\u2032 and 3\u2032 Untranslated Regions of the Flaviviral Genome. Viruses, 9.","DOI":"10.3390\/v9060137"},{"key":"ref_26","first-page":"19839","article-title":"Dengue viruses\u2014An overview","volume":"3","author":"Lundkvist","year":"2013","journal-title":"Infect. Ecol. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv. Virus Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.7150\/ijms.21875","article-title":"Peptides as Therapeutic Agents for Dengue Virus","volume":"14","author":"Chew","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"ref_29","first-page":"317","article-title":"Structure of Dengue Virus: Implications for Flavivirus Organization, Maturation, and Fusion","volume":"108","author":"Kuhn","year":"2014","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"El Sahili, A., and Lescar, J. (2017). Dengue Virus Non-Structural Protein 5. Viruses, 9.","DOI":"10.3390\/v9040091"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bcp.2018.04.008","article-title":"Dengue virus NS2 and NS4: Minor proteins, mammoth roles","volume":"154","author":"Reddy","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e01985-18","DOI":"10.1128\/JVI.01985-18","article-title":"The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from Mosquito Cells in Association with the Intracellular Cholesterol Transporter Chaperone Caveolin Complex","volume":"93","author":"Ramirez","year":"2019","journal-title":"J. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41598-019-39157-7","article-title":"Dengue virus nonstructural 3 protein interacts directly with human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and reduces its glycolytic activity","volume":"9","author":"Silva","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.virusres.2008.07.022","article-title":"Characterization of the interaction of domain III of the envelope protein of dengue virus with putative receptors from CHO cells","volume":"137","author":"Huerta","year":"2008","journal-title":"Virus Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/156652409787581592","article-title":"Dengue: Recent advances in biology and current status of translational research","volume":"9","author":"Swaminathan","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10543","DOI":"10.1128\/JVI.78.19.10543-10555.2004","article-title":"Infectious Entry of West Nile Virus Occurs through a Clathrin-Mediated Endocytic Pathway","volume":"78","author":"Chu","year":"2004","journal-title":"J. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.virol.2006.01.022","article-title":"Analysis of the endocytic pathway mediating the infectious entry of mosquito-borne flavivirus West Nile into Aedes albopictus mosquito (C6\/36) cells","volume":"349","author":"Chu","year":"2006","journal-title":"Virology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1128\/JVI.02210-06","article-title":"Rab 5 Is Required for the Cellular Entry of Dengue and West Nile Viruses","volume":"81","author":"Krishnan","year":"2007","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1128\/JVI.02957-12","article-title":"Structure of a Dengue Virus Envelope Protein Late-Stage Fusion Intermediate","volume":"87","author":"Klein","year":"2013","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature02165","article-title":"Structure of the dengue virus envelope protein after membrane fusion","volume":"427","author":"Modis","year":"2004","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Stiasny, K., K\u00f6ssl, C., Lepault, J., Rey, F.A., and Heinz, F.X. (2007). Characterization of a Structural Intermediate of Flavivirus Membrane Fusion. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030020"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1128\/JVI.00170-10","article-title":"In Vitro Reconstitution Reveals Key Intermediate States of Trimer Formation by the Dengue Virus Membrane Fusion Protein","volume":"84","author":"Liao","year":"2010","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1099\/vir.0.19062-0","article-title":"The membrane proteins of flaviviruses form ion-permeable pores in the target membrane after fusion: Identification of the pores and analysis of their possible role in virus infection","volume":"84","author":"Koschinski","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1128\/JVI.01257-06","article-title":"Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis","volume":"80","author":"Clyde","year":"2006","journal-title":"J. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1128\/jvi.71.11.8475-8481.1997","article-title":"Proteolytic activation of tick-borne encephalitis virus by furin","volume":"71","author":"Stadler","year":"1997","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Azami, N.A.M., Takasaki, T., Kurane, I., and Moi, M.L. (2020). Non-Human Primate Models of Dengue Virus Infection: A Comparison of Viremia Levels and Antibody Responses during Primary and Secondary Infection among Old World and New World Monkeys. Pathogens, 9.","DOI":"10.3390\/pathogens9040247"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00705-021-05298-2","article-title":"Mammalian animal models for dengue virus infection: A recent overview","volume":"167","author":"Kayesh","year":"2021","journal-title":"Arch. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1021\/acsinfecdis.8b00054","article-title":"Preclinical Antiviral Testing for Dengue Virus Infection in Mouse Models and Its Association with Clinical Studies","volume":"4","author":"Watanabe","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.antiviral.2015.08.013","article-title":"Animal models for studying dengue pathogenesis and therapy","volume":"123","author":"Chan","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12985-019-1127-7","article-title":"Efficacy of geraniin on dengue virus type-2 infected BALB\/c mice","volume":"16","author":"Ahmad","year":"2019","journal-title":"Virol. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1128\/JVI.05468-11","article-title":"Inhibition of Dengue Virus by Targeting Viral NS4B Protein","volume":"85","author":"Xie","year":"2011","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.antiviral.2019.05.004","article-title":"Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545","volume":"168","author":"Modhiran","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.virol.2017.11.009","article-title":"The antimicrobial peptide HS-1 inhibits dengue virus infection","volume":"514","author":"Monteiro","year":"2018","journal-title":"Virology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.virol.2013.08.009","article-title":"The interaction between claudin-1 and dengue viral prM\/M protein for its entry","volume":"446","author":"Che","year":"2013","journal-title":"Virology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1128\/JVI.78.1.378-388.2004","article-title":"An External Loop Region of Domain III of Dengue Virus Type 2 Envelope Protein Is Involved in Serotype-Specific Binding to Mosquito but Not Mammalian Cells","volume":"78","author":"Hung","year":"2004","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chom.2012.08.009","article-title":"The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry","volume":"12","author":"Meertens","year":"2012","journal-title":"Cell Host Microb."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Miller, J.L., de Wet, B.J., Martinez-Pomares, L., Radcliffe, C.M., Dwek, R.A., Rudd, P.M., and Gordon, S. (2008). The mannose receptor mediates dengue virus infection of macrophages. PLoS Pathog., 4.","DOI":"10.1371\/annotation\/98b92fca-fa6e-4bf3-9b39-13b66b640476"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1128\/JVI.79.8.4557-4567.2005","article-title":"Heat Shock Protein 90 and Heat Shock Protein 70 Are Components of Dengue Virus Receptor Complex in Human Cells","volume":"79","author":"Medina","year":"2005","journal-title":"J. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"12647","DOI":"10.1128\/JVI.78.22.12647-12656.2004","article-title":"Serotype-Specific Entry of Dengue Virus into Liver Cells: Identification of the 37-Kilodalton\/67-Kilodalton High-Affinity Laminin Receptor as a Dengue Virus Serotype 1 Receptor","volume":"78","author":"Thepparit","year":"2004","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1423-0127-20-40","article-title":"An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection","volume":"20","author":"Tsai","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/jcb.24037","article-title":"Endothelial cell surface expression of protein disulfide isomerase activates \u03b21 and \u03b23 integrins and facilitates dengue virus infection","volume":"113","author":"Wan","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2007.03.051","article-title":"Up-regulated expression of beta3 integrin induced by dengue virus serotype 2 infection associated with virus entry into human dermal microvascular endothelial cells","volume":"356","author":"Zhang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"116356","DOI":"10.1016\/j.bmc.2021.116356","article-title":"Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens","volume":"46","author":"Mahajan","year":"2021","journal-title":"Bioorganic Med. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1034\/j.1600-0463.2003.11107803.x","article-title":"Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity","volume":"111","author":"Geijtenbeek","year":"2003","journal-title":"Apmis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.embor.embor866","article-title":"Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses","volume":"4","author":"Altmeyer","year":"2003","journal-title":"EMBO Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"23698","DOI":"10.1074\/jbc.M504337200","article-title":"Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN)-mediated Enhancement of Dengue Virus Infection Is Independent of DC-SIGN Internalization Signals","volume":"280","author":"Lozach","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1128\/JVI.00116-07","article-title":"Essential Role of Dengue Virus Envelope Protein N Glycosylation at Asparagine-67 during Viral Propagation","volume":"81","author":"Mondotte","year":"2007","journal-title":"J. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Shah, M., Wadood, A., Rahman, Z., and Husnain, T. (2013). Interaction and Inhibition of Dengue Envelope Glycoprotein with Mammalian Receptor DC-Sign, an In-Silico Approach. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059211"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chen, J.-M., Fan, Y.-C., Lin, J.-W., Chen, Y.-Y., Hsu, W.-L., and Chiou, S.-S. (2017). Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091957"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Alen, M.M.F., De Burghgraeve, T., Kaptein, S.J.F., Balzarini, J., Neyts, J., and Schols, D. (2011). Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021658"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.biochem.71.110601.135458","article-title":"Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate","volume":"71","author":"Esko","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1053\/jhep.2000.18713","article-title":"Heparan sulfate proteoglycans initiate dengue virus infection of hepatocytes","volume":"32","author":"Hilgard","year":"2000","journal-title":"Hepatology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1099\/vir.0.028522-0","article-title":"Differential inhibition of dengue virus infection in mammalian and mosquito cells by iota-carrageenan","volume":"92","author":"Talarico","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1099\/vir.0.037317-0","article-title":"Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding","volume":"93","author":"Watterson","year":"2012","journal-title":"J. Gen. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"170797","DOI":"10.1016\/j.peptides.2022.170797","article-title":"PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion","volume":"153","author":"Giraldo","year":"2022","journal-title":"Peptides"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s00705-015-2579-8","article-title":"Beyond RGD: Virus interactions with integrins","volume":"160","author":"Hussein","year":"2015","journal-title":"Arch. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.antiviral.2018.04.018","article-title":"Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with \u03b23 integrin","volume":"155","author":"Cui","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chom.2013.07.005","article-title":"Enveloped Viruses Disable Innate Immune Responses in Dendritic Cells by Direct Activation of TAM Receptors","volume":"14","author":"Bhattacharyya","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/v6010069","article-title":"Flavivirus Entry Receptors: An Update","volume":"6","author":"Meertens","year":"2013","journal-title":"Viruses"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1099\/vir.0.83357-0","article-title":"Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis","volume":"89","author":"Acosta","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1462-5822.2009.01345.x","article-title":"Alternative infectious entry pathways for dengue virus serotypes into mammalian cells","volume":"11","author":"Acosta","year":"2009","journal-title":"Cell. Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"van der Schaar, H.M., Rust, M.J., Chen, C., van der Ende-Metselaar, H., Wilschut, J., Zhuang, X., and Smit, J.M. (2008). Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000244"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s007050050561","article-title":"A different mode of entry by dengue-2 neutralisation escape mutant virus","volume":"144","author":"Lim","year":"1999","journal-title":"Arch. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/jb\/mvj067","article-title":"Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2","volume":"139","author":"Aoki","year":"2006","journal-title":"J. Biochem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/viro.2001.1232","article-title":"Heparan Sulfate-Mediated Binding of Infectious Dengue Virus Type 2 and Yellow Fever Virus","volume":"292","author":"Germi","year":"2002","journal-title":"Virology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000089377","article-title":"Growth and production of the dengue virus in C6\/36 cells and identification of a laminin-binding protein as a candidate serotype 3 and 4 receptor protein","volume":"49","author":"Sakoonwatanyoo","year":"2006","journal-title":"Intervirology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/rmv.405","article-title":"Antibody-dependent enhancement of viral infection: Molecular mechanisms andin vivo implications","volume":"13","author":"Takada","year":"2003","journal-title":"Rev. Med. Virol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1348-0421.2010.00293.x","article-title":"Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells","volume":"55","author":"Wichit","year":"2011","journal-title":"Microbiol. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbrc.2008.08.100","article-title":"Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga","volume":"376","author":"Hidari","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.antiviral.2005.08.006","article-title":"Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses","volume":"69","author":"Lee","year":"2006","journal-title":"Antivir. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.antiviral.2005.02.001","article-title":"The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell","volume":"66","author":"Talarico","year":"2005","journal-title":"Antivir. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.antiviral.2008.05.007","article-title":"In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistries","volume":"80","author":"Rees","year":"2008","journal-title":"Antivir. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijbiomac.2012.05.028","article-title":"Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides","volume":"51","author":"Pujol","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ichiyama, K., Reddy, S.B.G., Zhang, L.F., Chin, W.-X., Muschin, T., Heinig, L., Suzuki, Y., Nanjundappa, H., Yoshinaka, Y., and Ryo, A. (2013). Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry\/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002188"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.antiviral.2010.09.002","article-title":"Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein","volume":"88","author":"Kato","year":"2010","journal-title":"Antivir. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-981-10-8727-1_22","article-title":"Dengue Antiviral Development: A Continuing Journey","volume":"1062","author":"Low","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd.2017.33","article-title":"Broad-spectrum agents for flaviviral infections: Dengue, Zika and beyond","volume":"16","author":"Boldescu","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coviro.2020.07.009","article-title":"Recent advances in antiviral drug development towards dengue virus","volume":"43","author":"Troost","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"7700","DOI":"10.1128\/JVI.00197-13","article-title":"Immature and Mature Dengue Serotype 1 Virus Structures Provide Insight into the Maturation Process","volume":"87","author":"Kostyuchenko","year":"2013","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Tang, C.-T., Liao, M.-Y., Chiu, C.-Y., Shen, W.-F., Chiu, C.-Y., Cheng, P.-C., Chang, G.-J.J., and Wu, H.-C. (2015). Generation of Monoclonal Antibodies against Dengue Virus Type 4 and Identification of Enhancing Epitopes on Envelope Protein. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136328"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Yu, K., Sheng, Z., Huang, B., Ma, X., Li, Y., Yuan, X., Qin, Z., Wang, D., Chakravarty, S., and Li, F. (2013). Structural, Antigenic, and Evolutionary Characterizations of the Envelope Protein of Newly Emerging Duck Tembusu Virus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071319"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1128\/JVI.75.16.7769-7773.2001","article-title":"Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero Cells","volume":"75","author":"Crill","year":"2001","journal-title":"J. Virol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1099\/vir.0.021220-0","article-title":"Characterization of a dengue type-specific epitope on dengue 3 virus envelope protein domain III","volume":"91","author":"Matsui","year":"2010","journal-title":"J. Gen. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.virol.2013.03.011","article-title":"Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion","volume":"441","author":"Roehrig","year":"2013","journal-title":"Virology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.str.2004.06.019","article-title":"Conformational Changes of the Flavivirus E Glycoprotein","volume":"12","author":"Zhang","year":"2004","journal-title":"Structure"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/JVI.02458-10","article-title":"The Unique Transmembrane Hairpin of Flavivirus Fusion Protein E Is Essential for Membrane Fusion","volume":"85","author":"Fritz","year":"2011","journal-title":"J. Virol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cbdd.12309","article-title":"Peptide Inhibitors Against Dengue Virus Infection","volume":"84","author":"Panya","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1743-422X-2-49","article-title":"Peptide inhibitors of dengue virus and West Nile virus infectivity","volume":"2","author":"Hrobowski","year":"2005","journal-title":"Virol. J."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Schmidt, A.G., Lee, K., Yang, P.L., and Harrison, S.C. (2012). Small-Molecule Inhibitors of Dengue-Virus Entry. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002627"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.antiviral.2009.09.011","article-title":"A small molecule fusion inhibitor of dengue virus","volume":"84","author":"Poh","year":"2009","journal-title":"Antivir. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1126\/science.1153263","article-title":"The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation","volume":"319","author":"Li","year":"2008","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00018-010-0357-z","article-title":"Dengue virus life cycle: Viral and host factors modulating infectivity","volume":"67","author":"Wilschut","year":"2010","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1871526510909030327","article-title":"New Approaches to Structure-Based Discovery of Dengue Protease Inhibitors","volume":"9","author":"Tomlinson","year":"2009","journal-title":"Infect. Disord. Drug Targ."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/cbdd.12576","article-title":"A Peptide Inhibitor Derived from the Conserved Ectodomain Region of DENV Membrane (M) Protein with Activity Against Dengue Virus Infection","volume":"86","author":"Panya","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Zheng, A., Umashankar, M., and Kielian, M. (2010). In Vitro and In Vivo Studies Identify Important Features of Dengue Virus pr-E Protein Interactions. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001157"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1128\/JVI.00704-13","article-title":"Nucleolin Interacts with the Dengue Virus Capsid Protein and Plays a Role in Formation of Infectious Virus Particles","volume":"87","author":"Balinsky","year":"2013","journal-title":"J. Virol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1073\/pnas.0305892101","article-title":"Solution structure of dengue virus capsid protein reveals another fold","volume":"101","author":"Ma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/cb500640t","article-title":"Understanding Dengue Virus Capsid Protein Disordered N-Terminus and pep14-23-Based Inhibition","volume":"10","author":"Faustino","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/AAC.01429-12","article-title":"A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein","volume":"57","author":"Byrd","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11540","DOI":"10.1128\/JVI.01745-14","article-title":"Characterization of the Mode of Action of a Potent Dengue Virus Capsid Inhibitor","volume":"88","author":"Scaturro","year":"2014","journal-title":"J. Virol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2018.04.019","article-title":"Characterization and structure-activity relationship analysis of a class of antiviral compounds that directly bind dengue virus capsid protein and are incorporated into virions","volume":"155","author":"Smith","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"12549","DOI":"10.1128\/JVI.01440-10","article-title":"Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem","volume":"84","author":"Schmidt","year":"2010","journal-title":"J. Virol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Schmidt, A.G., Yang, P.L., and Harrison, S.C. (2010). Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000851"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Costin, J.M., Jenwitheesuk, E., Lok, S.-M., Hunsperger, E., Conrads, K.A., Fontaine, K.A., Rees, C.R., Rossmann, M.G., Isern, S., and Samudrala, R. (2010). Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000721"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Yang, J.-M., Chen, Y.-F., Tu, Y.-Y., Yen, K.-R., and Yang, Y.-L. (2007). Combinatorial Computational Approaches to Identify Tetracycline Derivatives as Flavivirus Inhibitors. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000428"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.antiviral.2009.09.007","article-title":"In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses","volume":"84","author":"Kampmann","year":"2009","journal-title":"Antivir. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/AAC.01148-08","article-title":"A Small-Molecule Dengue Virus Entry Inhibitor","volume":"53","author":"Wang","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/cb800176t","article-title":"Antiviral Compounds Discovered by Virtual Screening of Small\u2013Molecule Libraries against Dengue Virus E Protein","volume":"3","author":"Zhou","year":"2008","journal-title":"ACS Chem. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/jam.12921","article-title":"Anti-dengue virus serotype 2 activity and mode of action of a novel peptide","volume":"119","author":"Chew","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12985-017-0895-1","article-title":"Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication","volume":"14","author":"Ahmad","year":"2017","journal-title":"Virol. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"719","DOI":"10.7150\/ijms.5037","article-title":"Inhibition of Dengue Virus Entry into Target Cells Using Synthetic Antiviral Peptides","volume":"10","author":"Alhoot","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1128\/JVI.01840-06","article-title":"Antiviral Peptides Targeting the West Nile Virus Envelope Protein","volume":"81","author":"Bai","year":"2007","journal-title":"J. Virol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.antiviral.2013.03.008","article-title":"The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker","volume":"98","author":"Muller","year":"2013","journal-title":"Antivir. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/viro.1996.0307","article-title":"Immunolocalization of the Dengue Virus Nonstructural Glycoprotein NS1 Suggests a Role in Viral RNA Replication","volume":"220","author":"Mackenzie","year":"1996","journal-title":"Virology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1016\/j.vaccine.2011.09.114","article-title":"Flaviviruses and flavivirus vaccines","volume":"30","author":"Heinz","year":"2012","journal-title":"Vaccine"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1086\/343813","article-title":"High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate with the Development of Dengue Hemorrhagic Fever","volume":"186","author":"Libraty","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"12933","DOI":"10.1038\/s41598-020-69515-9","article-title":"Peptides targeting dengue viral nonstructural protein 1 inhibit dengue virus production","volume":"10","author":"Songprakhon","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2016.12.049","article-title":"Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis","volume":"198","author":"Lee","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.coviro.2014.09.020","article-title":"Coupling of replication and assembly in flaviviruses","volume":"9","author":"Sirohi","year":"2014","journal-title":"Curr. Opin. Virol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2015.03.014","article-title":"The flavivirus NS2B\u2013NS3 protease\u2013helicase as a target for antiviral drug development","volume":"118","author":"Luo","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/emboj.2008.232","article-title":"Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein","volume":"27","author":"Luo","year":"2008","journal-title":"EMBO J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.antiviral.2009.12.011","article-title":"Strategies for development of dengue virus inhibitors","volume":"85","author":"Noble","year":"2010","journal-title":"Antivir. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/jac\/dks147","article-title":"Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: New prospects for an old drug","volume":"67","author":"Mastrangelo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1128\/AAC.02251-12","article-title":"Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase","volume":"57","author":"Byrd","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"251482","DOI":"10.1155\/2012\/251482","article-title":"Protegrin-1 Inhibits Dengue NS2B-NS3 Serine Protease and Viral Replication in MK2 Cells","volume":"2012","author":"Rothan","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Rothan, H.A., Han, H.C., Ramasamy, T.S., Othman, S., Rahman, N.A., and Yusof, R. (2012). Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1. BMC Infect. Dis., 12.","DOI":"10.1186\/1471-2334-12-314"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"85938","DOI":"10.1039\/C5RA14469H","article-title":"Reaching beyond HIV\/HCV: Nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus","volume":"5","author":"Bhakat","year":"2015","journal-title":"RSC Adv."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1074\/jbc.M609919200","article-title":"The Non-structural Protein 4A of Dengue Virus Is an Integral Membrane Protein Inducing Membrane Alterations in a 2K-regulated Manner","volume":"282","author":"Miller","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1128\/JVI.80.9.4623-4632.2006","article-title":"Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A Protein","volume":"80","author":"Roosendaal","year":"2006","journal-title":"J. Virol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"22147","DOI":"10.1074\/jbc.M110.192500","article-title":"Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication","volume":"286","author":"McLean","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","article-title":"Inhibition of interferon signaling by dengue virus","volume":"100","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00705-010-0816-8","article-title":"Restoration of replication-defective dengue type 1 virus bearing mutations in the N-terminal cytoplasmic portion of NS4A by additional mutations in NS4B","volume":"156","author":"Tajima","year":"2010","journal-title":"Arch. Virol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1016\/j.bbamem.2012.06.022","article-title":"NS4A and NS4B proteins from dengue virus: Membranotropic regions","volume":"1818","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/AAC.02462-15","article-title":"Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404","volume":"60","author":"Overheul","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1128\/JVI.00855-15","article-title":"Discovery of Dengue Virus NS4B Inhibitors","volume":"89","author":"Wang","year":"2015","journal-title":"J. Virol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2009.11.009","article-title":"Structure and functionality in flavivirus NS-proteins: Perspectives for drug design","volume":"87","author":"Bollati","year":"2010","journal-title":"Antivir. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"14362","DOI":"10.1074\/jbc.M110.214189","article-title":"Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase","volume":"286","author":"Zou","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Soh, T.S., Zheng, J., Chan, K.W.K., Phoo, W.W., Lee, C.C., Tay, M., Swaminathan, K., Cornvik, T.C., and Lim, S.P. (2015). A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004682"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e00047-17","DOI":"10.1128\/JVI.00047-17","article-title":"Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A","volume":"91","author":"Bujalowski","year":"2017","journal-title":"J. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Yang, S.N.Y., Maher, B., Wang, C., Wagstaff, K.M., Fraser, J.E., and Jans, D.A. (2022). High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses. Cells, 11.","DOI":"10.3390\/cells11040730"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41594-020-0472-y","article-title":"Structural basis for STAT2 suppression by flavivirus NS5","volume":"27","author":"Wang","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Panya, A., Songprakhon, P., Panwong, S., Jantakee, K., Kaewkod, T., Tragoolpua, Y., Sawasdee, N., Lee, V., Nimmanpipug, P., and Yenchitsomanus, P.-T. (2021). Cordycepin Inhibits Virus Replication in Dengue Virus-Infected Vero Cells. Molecules, 26.","DOI":"10.3390\/molecules26113118"},{"key":"ref_164","first-page":"250","article-title":"Phytochemical Study of Myrtopsis corymbosa, Perspectives for Anti-dengue Natural Compound Research","volume":"7","author":"Coulerie","year":"2013","journal-title":"Rec. Nat. Prod."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Shimizu, H., Saito, A., Mikuni, J., Nakayama, E.E., Koyama, H., Honma, T., Shirouzu, M., Sekine, S.-I., and Shioda, T. (2019). Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007894"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.antiviral.2011.12.003","article-title":"Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors","volume":"93","author":"Tomlinson","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2014.09.113","article-title":"Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format","volume":"453","author":"Basavannacharya","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/id5000458","article-title":"Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase","volume":"1","author":"Sweeney","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.antiviral.2012.08.006","article-title":"Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation","volume":"96","author":"Ndjomou","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e3196","DOI":"10.1002\/psc.3196","article-title":"Carnosine exhibits significant antiviral activity against Dengue and Zika virus","volume":"25","author":"Rothan","year":"2019","journal-title":"J. Pept. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00705-010-0702-4","article-title":"Identification of palmatine as an inhibitor of West Nile virus","volume":"155","author":"Jia","year":"2010","journal-title":"Arch. Virol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.antiviral.2012.02.008","article-title":"Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease","volume":"94","author":"Nitsche","year":"2012","journal-title":"Antivir. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/j.bmc.2011.05.015","article-title":"Synthesis and biological evaluation of \u03b1-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture","volume":"19","author":"Steuer","year":"2011","journal-title":"Bioorganic Med. Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ab.2009.08.013","article-title":"A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease","volume":"395","author":"Bodenreider","year":"2009","journal-title":"Anal. Biochem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3851\/IMP1767","article-title":"Small Molecule Pan-Dengue and West Nile Virus NS3 Protease Inhibitors","volume":"21","author":"Jiao","year":"2011","journal-title":"Antivir. Chem. Chemother."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.antiviral.2009.02.190","article-title":"Structure-based discovery of dengue virus protease inhibitors","volume":"82","author":"Tomlinson","year":"2009","journal-title":"Antivir. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bmc.2012.10.058","article-title":"Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B\/NS3 proteases","volume":"21","author":"Lai","year":"2012","journal-title":"Bioorganic Med. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/AAC.03543-14","article-title":"Novel Dengue Virus NS2B\/NS3 Protease Inhibitors","volume":"59","author":"Wu","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.antiviral.2016.08.014","article-title":"High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease","volume":"134","author":"Balasubramanian","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbrc.2013.09.078","article-title":"A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication","volume":"440","author":"Pambudi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"9354","DOI":"10.1021\/acs.jmedchem.5b01441","article-title":"Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue","volume":"58","author":"Behnam","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2180-14-140","article-title":"Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus","volume":"14","author":"Rothan","year":"2014","journal-title":"BMC Microbiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/AAC.01281-13","article-title":"A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B\/NS3 Protease","volume":"58","author":"Yang","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/aps.2015.56","article-title":"Policresulen, a novel NS2B\/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells","volume":"36","author":"Wu","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1128\/AAC.00855-10","article-title":"Novel Dengue Virus-Specific NS2B\/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay","volume":"55","author":"Yang","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12985-015-0248-x","article-title":"A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture","volume":"12","author":"Raut","year":"2015","journal-title":"Virol. J."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1021\/acs.jmedchem.5b00612","article-title":"Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors","volume":"58","author":"Weigel","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cbdd.12500","article-title":"Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease","volume":"86","author":"Li","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1128\/JVI.00632-13","article-title":"The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase","volume":"87","author":"LaCroix","year":"2013","journal-title":"J. Virol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.antiviral.2017.10.011","article-title":"Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library","volume":"147","author":"Geluykens","year":"2017","journal-title":"Antivir. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"eabb2181","DOI":"10.1126\/scitranslmed.abb2181","article-title":"NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models","volume":"13","author":"Moquin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-021-03990-6","article-title":"A pan-serotype dengue virus inhibitor targeting the NS3\u2013NS4B interaction","volume":"598","author":"Kaptein","year":"2021","journal-title":"Nature"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.antiviral.2018.05.003","article-title":"Identification of Compound-B, a novel anti-dengue virus agent targeting the non-structural protein 4A","volume":"155","author":"Nobori","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1021\/acs.jmedchem.5b00327","article-title":"5\u2032-Silylated 3\u2032-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus","volume":"58","author":"Vernekar","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1074\/jbc.M110.179184","article-title":"Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase","volume":"286","author":"Lim","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Bullard, K.M., Gullberg, R.C., Soltani, E., Steel, J.J., Geiss, B.J., and Keenan, S.M. (2015). Murine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-Thioxothiazolidin-4-One Inhibitor BG-323. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130083"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acsinfecdis.5b00070","article-title":"Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase","volume":"1","author":"Brecher","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.phytochem.2012.07.023","article-title":"Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri","volume":"84","author":"Allard","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1021\/np200715v","article-title":"Alkylated Flavanones from the Bark of Cryptocarya chartacea As Dengue Virus NS5 Polymerase Inhibitors","volume":"74","author":"Allard","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_200","first-page":"286","article-title":"New Inhibitors of the DENV-NS 5 RdRp from Carpolepis laurifolia as Potential Antiviral Drugs for Dengue Treatment","volume":"8","author":"Coulerie","year":"2014","journal-title":"Rec. Nat. Prod."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/acsmedchemlett.9b00619","article-title":"Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase","volume":"11","author":"Cannalire","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.fitote.2012.05.004","article-title":"Chemical constituents of Anacolosa pervilleana and their antiviral activities","volume":"83","author":"Bourjot","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1128\/AAC.48.10.3944-3953.2004","article-title":"A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties","volume":"48","author":"Olsen","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/AAC.01335-10","article-title":"INX-08189, a Phosphoramidate Prodrug of 6- O -Methyl-2\u2032- C -Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties","volume":"55","author":"Vernachio","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren","year":"2014","journal-title":"Nature"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1128\/JVI.02841-13","article-title":"Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir","volume":"88","author":"Chen","year":"2014","journal-title":"J. Virol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"20435","DOI":"10.1073\/pnas.0907010106","article-title":"An adenosine nucleoside inhibitor of dengue virus","volume":"106","author":"Yin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2015.01.002","article-title":"Characterization of the activity of 2\u2032-C-methylcytidine against dengue virus replication","volume":"116","author":"Lee","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_209","first-page":"15","article-title":"Control of Dengue Virus Translation and Replication","volume":"338","author":"Paranjape","year":"2009","journal-title":"Poxviruses"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1128\/AAC.00140-10","article-title":"Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside","volume":"54","author":"Chen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/viro.2002.1685","article-title":"Mycophenolic Acid Inhibits Dengue Virus Infection by Preventing Replication of Viral RNA","volume":"304","author":"Diamond","year":"2002","journal-title":"Virology"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1128\/JVI.79.13.8303-8315.2005","article-title":"Control of Translation by the 5\u2032- and 3\u2032-Terminal Regions of the Dengue Virus Genome","volume":"79","author":"Chiu","year":"2005","journal-title":"J. Virol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2004.08.004","article-title":"Enhancement of dengue virus translation: Role of the 3\u2032 untranslated region and the terminal 3\u2032 stem-loop domain","volume":"329","author":"Holden","year":"2004","journal-title":"Virology"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1128\/JVI.02455-06","article-title":"Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events","volume":"81","author":"Dong","year":"2007","journal-title":"J. Virol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1128\/AAC.00620-11","article-title":"A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo","volume":"55","author":"Wang","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3851\/IMP1884","article-title":"Narasin, a Novel Antiviral Compound that Blocks Dengue Virus Protein Expression","volume":"16","author":"Low","year":"2011","journal-title":"Antivir. Ther."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2016.02.005","article-title":"Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses","volume":"128","author":"Carocci","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"104589","DOI":"10.1016\/j.antiviral.2019.104589","article-title":"Antiviral activity of ST081006 against the dengue virus","volume":"171","author":"Lee","year":"2019","journal-title":"Antivir. Res."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.antiviral.2016.04.014","article-title":"Novel antiviral activity of bromocriptine against dengue virus replication","volume":"131","author":"Kato","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.virol.2005.08.034","article-title":"Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3\u2032 stem\u2013loop structure","volume":"344","author":"Holden","year":"2005","journal-title":"Virology"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jinf.2014.12.001","article-title":"Cellular microRNA-miR-548g-3p modulates the replication of dengue virus","volume":"70","author":"Wen","year":"2015","journal-title":"J. Infect."},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Castillo, J.A., Castrill\u00f3n, J.C., Diosa-Toro, M., Betancur, J.G., Iii, G.S.L., Smit, J.M., and Urcuqui-Inchima, S. (2015). Complex interaction between dengue virus replication and expression of miRNA-133a. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1364-y"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/0074-02760160404","article-title":"Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication","volume":"112","year":"2017","journal-title":"Mem\u00f3rias Inst. Oswaldo Cruz"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Yeh, S.-C., Diosa-Toro, M., Tan, W.-L., Rachenne, F., Hain, A., Yeo, C.P.X., Bribes, I., Xiang, B.W.W., Kannan, G.S., and Manuel, M.C. (2022). Characterization of dengue virus 3\u2019UTR RNA binding proteins in mosquitoes reveals that AeStaufen reduces subgenomic flaviviral RNA in saliva. PLoS Pathog., 18.","DOI":"10.1101\/2022.03.11.483893"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1261\/rna.064006.117","article-title":"Identification and characterization of host proteins bound to dengue virus 3\u2032 UTR reveal an antiviral role for quaking proteins","volume":"24","author":"Liao","year":"2018","journal-title":"RNA"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tibs.2020.12.007","article-title":"Molecular Determinants of Flavivirus Virion Assembly","volume":"46","author":"Barnard","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chom.2019.09.015","article-title":"Dengue NS2A Protein Orchestrates Virus Assembly","volume":"26","author":"Xie","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1128\/JVI.02447-07","article-title":"Yellow Fever Virus NS3 Plays an Essential Role in Virus Assembly Independent of Its Known Enzymatic Functions","volume":"82","author":"Patkar","year":"2008","journal-title":"J. Virol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1128\/JVI.03351-14","article-title":"A Basic Cluster in the N Terminus of Yellow Fever Virus NS2A Contributes to Infectious Particle Production","volume":"89","author":"Wieseler","year":"2015","journal-title":"J. Virol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-virology-110615-042334","article-title":"Properties and Functions of the Dengue Virus Capsid Protein","volume":"3","author":"Byk","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Nanaware, N., Banerjee, A., Bagchi, S.M., Bagchi, P., and Mukherjee, A. (2021). Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses. Viruses, 13.","DOI":"10.3390\/v13101967"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.emboj.7600064","article-title":"Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation","volume":"23","author":"Bressanelli","year":"2004","journal-title":"EMBO J."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1128\/JVI.01637-09","article-title":"Association of the pr Peptides with Dengue Virus at Acidic pH Blocks Membrane Fusion","volume":"83","author":"Yu","year":"2009","journal-title":"J. Virol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2008.06.041","article-title":"Novel binding between pre-membrane protein and vacuolar ATPase is required for efficient dengue virus secretion","volume":"373","author":"Duan","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mib.2008.06.004","article-title":"Structural proteomics of dengue virus","volume":"11","author":"Perera","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.1153264","article-title":"Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation","volume":"319","author":"Yu","year":"2008","journal-title":"Science"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000321892","article-title":"Statins Reduce Dengue Virus Production via Decreased Virion Assembly","volume":"54","author":"Castellanos","year":"2011","journal-title":"Intervirology"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1073\/pnas.0611681104","article-title":"c-Src protein kinase inhibitors block assembly and maturation of dengue virus","volume":"104","author":"Chu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3389\/fmicb.2017.01674","article-title":"Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle","volume":"8","author":"Hishiki","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1128\/JVI.79.14.8698-8706.2005","article-title":"Castanospermine, a Potent Inhibitor of Dengue Virus Infection In Vitro and In Vivo","volume":"79","author":"Whitby","year":"2005","journal-title":"J. Virol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s41182-017-0072-7","article-title":"Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses","volume":"45","author":"Raekiansyah","year":"2017","journal-title":"Trop. Med. Health"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ymthe.2020.12.016","article-title":"Synergistic and Antagonistic Drug Combinations against SARS-CoV-2","volume":"29","author":"Bobrowski","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.drudis.2021.05.008","article-title":"Drug combination therapy for emerging viral diseases","volume":"26","author":"Shyr","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.antiviral.2010.11.002","article-title":"Combination of \u03b1-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo","volume":"89","author":"Chang","year":"2011","journal-title":"Antivir. Res."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Franco, E., de Mello, C.P., and Brown, A. (2021). Antiviral Evaluation of UV-4B and Interferon-Alpha Combination Regimens against Dengue Virus. Viruses, 13.","DOI":"10.3390\/v13050771"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/3\/705\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:17Z","timestamp":1760122277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/3\/705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":245,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["v15030705"],"URL":"https:\/\/doi.org\/10.3390\/v15030705","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]}}}