{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:22:48Z","timestamp":1771464168379,"version":"3.50.1"},"reference-count":86,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NINDS R01","award":["NS055644"],"award-info":[{"award-number":["NS055644"]}]},{"name":"NIH\/NINDS R01","award":["GM121288"],"award-info":[{"award-number":["GM121288"]}]},{"name":"NIH\/NIGMS P20","award":["NS055644"],"award-info":[{"award-number":["NS055644"]}]},{"name":"NIH\/NIGMS P20","award":["GM121288"],"award-info":[{"award-number":["GM121288"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The human neurotropic Polyomavirus JCPyV is the widespread opportunistic causative pathogen of the fatal demyelinating disease progressive multifocal leukoencephalopathy; however, it has also been implicated in the oncogenesis of several types of cancers. It causes brain tumors when intracerebrally inoculated into rodents, and genomic sequences of different strains and expression of the viral protein large T-Antigen have been detected in a wide variety of glial brain tumors and CNS lymphomas. Here, we present a case of an AIDS-related multifocal primary CNS lymphoma in which JCPyV genomic sequences of the three regions of JCPyV and expression of T-Antigen were detected by PCR and immunohistochemistry, respectively. No capsid proteins were detected, ruling out active JCPyV replication. Sequencing of the control region revealed that Mad-4 was the strain of JCPyV present in tumor cells. In addition, expression of viral proteins LMP and EBNA-1 from another ubiquitous oncogenic virus, Epstein\u2013Barr, was also detected in the same lymphocytic neoplastic cells, co-localizing with JCPyV T-Antigen, suggesting a potential collaboration between these two viruses in the process of malignant transformation of B-lymphocytes, which are the site of latency and reactivation for both viruses.<\/jats:p>","DOI":"10.3390\/v15030755","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:36:36Z","timestamp":1678862196000},"page":"755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Co-Detection of EBV and Human Polyomavirus JCPyV in a Case of AIDS-Related Multifocal Primary Central Nervous System Diffuse Large B-Cell Lymphoma"],"prefix":"10.3390","volume":"15","author":[{"given":"Mallory T.","family":"Barbier","sequence":"first","affiliation":[{"name":"Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-9206","authenticated-orcid":false,"given":"Luis","family":"Del Valle","sequence":"additional","affiliation":[{"name":"Louisiana Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"Department of Pathology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","first-page":"1359","article-title":"Intracranial sarcomatous tumors of leptomeningeal origin","volume":"18","author":"Bailey","year":"1929","journal-title":"JAMA Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/1097-0142(197410)34:4<1293::AID-CNCR2820340441>3.0.CO;2-P","article-title":"Primary malignant lymphomas of the central nervous system","volume":"34","author":"Henry","year":"1974","journal-title":"Cancer"},{"key":"ref_3","unstructured":"WHO Classification of Tumours Editorial Board (2021). 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