{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:38:30Z","timestamp":1790908710623,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"cats\u2019 guardians and the subscribers"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>After an incubation period of weeks to months, up to 14% of cats infected with feline coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal pyogranulomatous perivasculitis. The aim of this study was to find out if stopping FCoV faecal shedding with antivirals prevents FIP. Guardians of cats from which FCoV had been eliminated at least 6 months earlier were contacted to find out the outcome of their cats; 27 households were identified containing 147 cats. Thirteen cats were treated for FIP, 109 cats shed FCoV and 25 did not; a 4\u20137-day course of oral GS-441524 antiviral stopped faecal FCoV shedding. Follow-up was from 6 months to 3.5 years; 11 of 147 cats died, but none developed FIP. A previous field study of 820 FCoV-exposed cats was used as a retrospective control group; 37 of 820 cats developed FIP. The difference was statistically highly significant (p = 0.0062). Cats from eight households recovered from chronic FCoV enteropathy. Conclusions: the early treatment of FCoV-infected cats with oral antivirals prevented FIP. Nevertheless, should FCoV be re-introduced into a household, then FIP can result. Further work is required to establish the role of FCoV in the aetiology of feline inflammatory bowel disease.<\/jats:p>","DOI":"10.3390\/v15040818","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T04:31:05Z","timestamp":1679632265000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-2661","authenticated-orcid":false,"given":"Diane D.","family":"Addie","sequence":"first","affiliation":[{"name":"Maison Zabal, 64470 Etchebar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Bellini","sequence":"additional","affiliation":[{"name":"Independent Researcher, Flora Bellini, Uxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Covell-Ritchie","sequence":"additional","affiliation":[{"name":"Independent Researcher, Johanna Covell-Ritchie, Maidstone, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Crowe","sequence":"additional","affiliation":[{"name":"Independent Researcher, Ben Crowe, Uxbridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Curran","sequence":"additional","affiliation":[{"name":"Independent Researcher, Sheryl Curran, Baker Street Ragdolls, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fosbery","sequence":"additional","affiliation":[{"name":"Mark Fosbery, Newnham Vets, Maidstone, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Hills","sequence":"additional","affiliation":[{"name":"Stuart Hills, Ark Veterinary Centre, Lockerbie, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Johnson","sequence":"additional","affiliation":[{"name":"Independent Researcher, Eric Johnson, Firestone, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Johnson","sequence":"additional","affiliation":[{"name":"Independent Researcher, Carrie Johnson, Firestone, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Steve Lloyd, Zoologix Laboratory, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswald","family":"Jarrett","sequence":"additional","affiliation":[{"name":"Oswald Jarrett, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/JVI.72.5.4508-4514.1998","article-title":"Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus","volume":"72","author":"Herrewegh","year":"1998","journal-title":"J. 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