{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:25:08Z","timestamp":1784744708546,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPERJ-JCNE","award":["e-26\/201.406\/2021"],"award-info":[{"award-number":["e-26\/201.406\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Parvovirus B19 (B19V) infection varies clinically depending on the host\u2019s immune status. Due to red blood cell precursors tropism, B19V can cause chronic anemia and transient aplastic crisis in patients with immunosuppression or chronic hemolysis. We report three rare cases of Brazilian adults living with human immunodeficiency virus (HIV) with B19V infection. All cases presented severe anemia and required red blood cell transfusions. The first patient had low CD4+ counts and was treated with intravenous immunoglobulin (IVIG). As he remained poorly adherent to antiretroviral therapy (ART), B19V detection persisted. The second patient had sudden pancytopenia despite being on ART with an undetectable HIV viral load. He had historically low CD4+ counts, fully responded to IVIG, and had undiagnosed hereditary spherocytosis. The third individual was recently diagnosed with HIV and tuberculosis (TB). One month after ART initiation, he was hospitalized with anemia aggravation and cholestatic hepatitis. An analysis of his serum revealed B19V DNA and anti-B19V IgG, corroborating bone marrow findings and a persistent B19V infection. The symptoms resolved and B19V became undetectable. In all cases, real time PCR was essential for diagnosing B19V. Our findings showed that adherence to ART was crucial to B19V clearance in HIV-patients and highlighted the importance of the early recognition of B19V disease in unexplained cytopenias.<\/jats:p>","DOI":"10.3390\/v15051124","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:00:28Z","timestamp":1683514828000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Presentation of Parvovirus B19 Infection in Adults Living with HIV\/AIDS: A Case Series"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-4774","authenticated-orcid":false,"given":"Daniela P.","family":"Mendes-de-Almeida","sequence":"first","affiliation":[{"name":"Hematology Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"},{"name":"Research Center, Instituto Nacional de C\u00e2ncer (INCA), Rio de Janeiro 20220-430, RJ, Brazil"},{"name":"Department of Medical Affairs, Clinical Studies, and Post-Registration Surveillance (DEAME), Institute of Technology in Immunobiologicals\/Bio-Manguinhos, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna Paes Barreto","family":"Bokel","sequence":"additional","affiliation":[{"name":"Hematology Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"},{"name":"Onco-Hematology Unit, Cl\u00ednica S\u00e3o Vicente, Rio de Janeiro 22451-100, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6371-6482","authenticated-orcid":false,"given":"Arthur Daniel Rocha","family":"Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Technological Development in Virology, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre G.","family":"Vizzoni","sequence":"additional","affiliation":[{"name":"Hematology Department, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Cristina Ferreira","family":"Tavares","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on STD\/AIDS, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Secco Torres","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on STD\/AIDS, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-3197","authenticated-orcid":false,"given":"Juliana dos Santos Barbosa","family":"Netto","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on STD\/AIDS, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Gilda Jegerhorn","family":"Grinsztejn","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on STD\/AIDS, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Almeida","family":"Amado Leon","sequence":"additional","affiliation":[{"name":"Laboratory of Technological Development in Virology, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-360, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2796.2006.01697.x","article-title":"Clinical Aspects of Parvovirus B19 Infection","volume":"260","author":"Broliden","year":"2006","journal-title":"J. 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