{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:59Z","timestamp":1789588439657,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-75-10112"],"award-info":[{"award-number":["20-75-10112"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-315-60012"],"award-info":[{"award-number":["19-315-60012"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-75-10112"],"award-info":[{"award-number":["20-75-10112"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-315-60012"],"award-info":[{"award-number":["19-315-60012"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hyperactivation of the immune system remains a dramatic, life-threatening complication of viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to counteract local and systemic outbreaks of cytokine storm and to prevent tissue damage remain limited. Cyclin-dependent kinases 8 and 19 (CDK8\/19) potentiate transcriptional responses to the altered microenvironment, but CDK8\/19 potential in immunoregulation is not fully understood. In the present study, we investigated how a selective CDK8\/19 inhibitor, Senexin B, impacts the immunogenic profiles of monocytic cells stimulated using influenza virus H1N1 or bacterial lipopolysaccharides. Senexin B was able to prevent the induction of gene expression of proinflammatory cytokines in THP1 and U937 cell lines and in human peripheral blood-derived mononuclear cells. Moreover, Senexin B substantially reduced functional manifestations of inflammation, including clustering and chemokine-dependent migration of THP1 monocytes and human pulmonary fibroblasts (HPF).<\/jats:p>","DOI":"10.3390\/v15061292","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T02:01:15Z","timestamp":1685498475000},"page":"1292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of Cyclin-Dependent Kinases 8\/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes"],"prefix":"10.3390","volume":"15","author":[{"given":"Elena K.","family":"Kokinos","sequence":"first","affiliation":[{"name":"SCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-6767","authenticated-orcid":false,"given":"Sergey A.","family":"Tsymbal","sequence":"additional","affiliation":[{"name":"SCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia V.","family":"Galochkina","sequence":"additional","affiliation":[{"name":"Smorodintsev Research Institute of Influenza, 15\/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6592-1575","authenticated-orcid":false,"given":"Svetlana A.","family":"Bezlepkina","sequence":"additional","affiliation":[{"name":"SCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia V.","family":"Nikolaeva","sequence":"additional","affiliation":[{"name":"Smorodintsev Research Institute of Influenza, 15\/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia O.","family":"Vershinina","sequence":"additional","affiliation":[{"name":"SCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Shtro","sequence":"additional","affiliation":[{"name":"Smorodintsev Research Institute of Influenza, 15\/17 Prof. Popov Street, 197376 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-5683","authenticated-orcid":false,"given":"Victor V.","family":"Tatarskiy","sequence":"additional","affiliation":[{"name":"Institute of Gene Biology, Russian Academy of Sciences, 34\/5 Vavilova Street, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Shtil","sequence":"additional","affiliation":[{"name":"Blokhin National Medical Research Center of Oncology, Kashirskoe Highway 24, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia V.","family":"Broude","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Sumter Street 715, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-1327","authenticated-orcid":false,"given":"Igor B.","family":"Roninson","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Sumter Street 715, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Dukhinova","sequence":"additional","affiliation":[{"name":"SCAMT Institute, ITMO University, 9 Lomonosova Street, 191002 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin. 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