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MH100928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R25MH081482"],"award-info":[{"award-number":["R25MH081482"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>We determined the prevalence of Alzheimer\u2019s disease (AD) pathological hallmarks, amyloid-\u03b2 and phosphorylated-Tau, in autopsied brains of 49 people with HIV (PWH) (ages: 50\u201368; mean age = 57.0) from the National NeuroAIDS Tissue Consortium and in a comparative cohort of 55 people without HIV (PWoH) from the UC San Diego Alzheimer\u2019s Disease Research Center (17 controls, 14 mild cognitive impairment, 24 AD; ages: 70\u2013102, mean age = 88.7). We examined how AD pathology relates to domain-specific cognitive functions in PWH overall and in sex-stratified samples. Amyloid-\u03b2 and phosphorylated-Tau positivity (presence of pathology of any type\/density) was determined via immunohistochemistry in AD-sensitive brain regions. Among PWH, amyloid-\u03b2 positivity ranged from 19% (hippocampus) to 41% (frontal neocortex), and phosphorylated-Tau positivity ranged from 47% (entorhinal cortex) to 73% (transentorhinal cortex). Generally, AD pathology was significantly less prevalent, and less severe when present, in PWH versus PWoH regardless of cognitive status. Among PWH, positivity for AD pathology related most consistently to memory-related domains. Positivity for p-Tau pathology related to memory-related domains in women with HIV only, although the sample size of women with HIV was small (n = 10). Results indicate that AD pathology is present in a sizable portion of middle aged and older PWH, although not to the extent in older PWoH. Studies with better age-matched PWoH are needed to examine the effect of HIV status on AD pathology.<\/jats:p>","DOI":"10.3390\/v15061319","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T01:53:25Z","timestamp":1685930005000},"page":"1319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alzheimer\u2019s Disease Pathology in Middle Aged and Older People with HIV: Comparisons with Non-HIV Controls on a Healthy Aging and Alzheimer\u2019s Disease Trajectory and Relationships with Cognitive Function"],"prefix":"10.3390","volume":"15","author":[{"given":"Erin E.","family":"Sundermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"},{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Villers","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"},{"name":"VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Gouaux","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego, 9375 Gilman Dr., La Jolla, CA 92161, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego, 9375 Gilman Dr., La Jolla, CA 92161, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virawudh","family":"Soontornniyomkij","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-752X","authenticated-orcid":false,"given":"Ronald J.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"},{"name":"Department of Neurosciences, University of California San Diego, 9375 Gilman Dr., La Jolla, CA 92161, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,4]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 01). 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