{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:44:07Z","timestamp":1791438247583,"version":"4.3.3"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal do Ensino Superior\u2014Brasil","award":["88881.130813\/2016-01"],"award-info":[{"award-number":["88881.130813\/2016-01"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal do Ensino Superior\u2014Brasil","award":["440573\/2016-5"],"award-info":[{"award-number":["440573\/2016-5"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal do Ensino Superior\u2014Brasil","award":["008\/2016"],"award-info":[{"award-number":["008\/2016"]}]},{"name":"Conselho Nacional de Desenvolvimento e Pesquisa","award":["88881.130813\/2016-01"],"award-info":[{"award-number":["88881.130813\/2016-01"]}]},{"name":"Conselho Nacional de Desenvolvimento e Pesquisa","award":["440573\/2016-5"],"award-info":[{"award-number":["440573\/2016-5"]}]},{"name":"Conselho Nacional de Desenvolvimento e Pesquisa","award":["008\/2016"],"award-info":[{"award-number":["008\/2016"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Maranh\u00e3o","award":["88881.130813\/2016-01"],"award-info":[{"award-number":["88881.130813\/2016-01"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Maranh\u00e3o","award":["440573\/2016-5"],"award-info":[{"award-number":["440573\/2016-5"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Maranh\u00e3o","award":["008\/2016"],"award-info":[{"award-number":["008\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers\u2019 and children\u2019s immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers\u2019 immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.<\/jats:p>","DOI":"10.3390\/v15061320","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T01:53:25Z","timestamp":1685930005000},"page":"1320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-9379","authenticated-orcid":false,"given":"Eder M. 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C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020-240, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros\u00e2ngela F. L.","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020-060, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020-060, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via R. F.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Health Sciences Graduate Program, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, MA, Brazil"},{"name":"Department of Pathology, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65065-545, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio A. M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020-060, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-3138","authenticated-orcid":false,"given":"Paulo V.","family":"Soeiro-Pereira","sequence":"additional","affiliation":[{"name":"Health Sciences Graduate Program, Biological and Health Sciences Center, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, MA, Brazil"},{"name":"Department of Pathology, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65065-545, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/0074-02760150192","article-title":"First Report of Autochthonous Transmission of Zika Virus in Brazil","volume":"110","author":"Zanluca","year":"2015","journal-title":"Mem. 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