{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:46:52Z","timestamp":1782812812513,"version":"3.54.5"},"reference-count":132,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R01DA047822"],"award-info":[{"award-number":["R01DA047822"]}]},{"name":"NIH","award":["P50DA026306"],"award-info":[{"award-number":["P50DA026306"]}]},{"name":"NIH","award":["P30MH062512"],"award-info":[{"award-number":["P30MH062512"]}]},{"name":"NIH","award":["R01DA047879"],"award-info":[{"award-number":["R01DA047879"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>There is a significant overlap between HIV infection and substance-use disorders. Dopamine (DA) is the most abundantly upregulated neurotransmitter in methamphetamine abuse, with receptors (DRD1-5) that are expressed by neurons as well as by a large diversity of cell types, including innate immune cells that are the targets of HIV infection, making them responsive to the hyperdopaminergic environment that is characteristic of stimulant drugs. Therefore, the presence of high levels of dopamine may affect the pathogenesis of HIV, particularly in the brain. The stimulation of HIV latently infected U1 promonocytes with DA significantly increased viral p24 levels in the supernatant at 24 h, suggesting effects on activation and replication. Using selective agonists to different DRDs, we found that DRD1 played a major role in activating viral transcription, followed by DRD4, which increased p24 with a slower kinetic rate compared to DRD1. Transcriptome and systems biology analyses led to the identification of a cluster of genes responsive to DA, where S100A8 and S100A9 were most significantly correlated with the early increase in p24 levels following DA stimulation. Conversely, DA increased the expression of these genes\u2019 transcripts at the protein level, MRP8 and MRP14, respectively, which form a complex also known as calprotectin. Interestingly, MRP8\/14 was able to stimulate HIV transcription in latent U1 cells, and this occurred via binding of the complex to the receptor for an advanced glycosylation end-product (RAGE). Using selective agonists, both DRD1 and DRD4 increased MRP8\/14 on the surface, in the cytoplasm, as well as secreted in the supernatants. On the other hand, while DRD1\/5 did not affect the expression of RAGE, DRD4 stimulation caused its downregulation, offering a mechanism for the delayed effect via DRD4 on the p24 increase. To cross-validate MRP8\/14 as a DA signature with a biomarker value, we tested its expression in HIV+ Meth users\u2019 postmortem brain specimens and peripheral cells. MRP8\/14+ cells were more frequently identified in mesolimbic areas such as the basal ganglia of HIV+ Meth+ cases compared to HIV+ non-Meth users or to controls. Likewise, MRP8\/14+ CD11b+ monocytes were more frequent in HIV+ Meth users, particularly in specimens from participants with a detectable viral load in the CSF. Overall, our results suggest that the MRP8 and MRP14 complex may serve as a signature to distinguish subjects using addictive substances in the context of HIV, and that this may play a role in aggravating HIV pathology by promoting viral replication in people with HIV who use Meth.<\/jats:p>","DOI":"10.3390\/v15061363","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T02:00:45Z","timestamp":1686621645000},"page":"1363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MRP8\/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology"],"prefix":"10.3390","volume":"15","author":[{"given":"Liana V.","family":"Basova","sequence":"first","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lindsey","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"McGovern","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Rosander","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"},{"name":"Human Biology Program BISP, University of California San Diego, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Delorme-Walker","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7594-7205","authenticated-orcid":false,"given":"Wael M.","family":"ElShamy","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ved Vasishtha","family":"Pendyala","sequence":"additional","affiliation":[{"name":"Systems Biology Internship, Creighton Preparatory School, Omaha, NE 68114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-5424","authenticated-orcid":false,"given":"Peter Jesse","family":"Gaskill","sequence":"additional","affiliation":[{"name":"College of Medicine, Drexel University, Philadelphia, PA 19102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-752X","authenticated-orcid":false,"given":"Ronald J.","family":"Ellis","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Cherner","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Iudicello","sequence":"additional","affiliation":[{"name":"HIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA 92103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4705-372X","authenticated-orcid":false,"given":"Maria Cecilia Garibaldi","family":"Marcondes","sequence":"additional","affiliation":[{"name":"San Diego Biomedical Research Institute, San Diego, CA 92121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cell.2015.01.020","article-title":"HIV-1 integration landscape during latent and active infection","volume":"160","author":"Cohn","year":"2015","journal-title":"Cell"},{"key":"ref_2","first-page":"121","article-title":"The latent reservoir for HIV-1 in resting CD4+ T cells: A barrier to cure","volume":"1","author":"Siliciano","year":"2006","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nat. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2353\/ajpath.2010.090953","article-title":"Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys","volume":"177","author":"Marcondes","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1080\/09540121.2012.672718","article-title":"Methamphetamine use and neuropsychiatric factors are associated with antiretroviral non-adherence","volume":"24","author":"Moore","year":"2012","journal-title":"AIDS Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tim.2016.01.006","article-title":"HIV-1 Reservoirs During Suppressive Therapy","volume":"24","author":"Barton","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1097\/QAD.0000000000000400","article-title":"Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation","volume":"28","author":"Dahl","year":"2014","journal-title":"AIDS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.0800050105","article-title":"Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy","volume":"105","author":"Palmer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/infdis\/jir208","article-title":"Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy","volume":"204","author":"Chun","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/77481","article-title":"Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy","volume":"6","author":"Chun","year":"2000","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Papasavvas, E., Kostman, J.R., Mounzer, K., Grant, R.M., Gross, R., Gallo, C., Azzoni, L., Foulkes, A., Thiel, B., and Pistilli, M. (2004). Randomized, controlled trial of therapy interruption in chronic HIV-1 infection. PLoS Med., 1.","DOI":"10.1371\/journal.pmed.0010064"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1097\/00002030-200008180-00004","article-title":"Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression","volume":"14","author":"Orenstein","year":"2000","journal-title":"AIDS"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13550280600748946","article-title":"Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues","volume":"12","author":"Churchill","year":"2006","journal-title":"J. Neurovirol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1086\/500983","article-title":"Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model","volume":"193","author":"Barber","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1750-3639.2002.tb00461.x","article-title":"Human brain parenchymal microglia express CD14 and CD45 and are productively infected by HIV-1 in HIV-1 encephalitis","volume":"12","author":"Cosenza","year":"2002","journal-title":"Brain Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1189\/jlb.0503204","article-title":"The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection","volume":"74","author":"Crowe","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"ref_17","first-page":"S67","article-title":"Understanding HIV-1 infection of the brain: A challenge for neurobiologists","volume":"4","author":"Jordan","year":"1990","journal-title":"AIDS"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1126\/science.2200125","article-title":"Specific tropism of HIV-1 for microglial cells in primary human brain cultures","volume":"249","author":"Watkins","year":"1990","journal-title":"Science"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1073\/pnas.83.18.7089","article-title":"Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients","volume":"83","author":"Wiley","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1086\/653213","article-title":"Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA","volume":"202","author":"Zink","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/ijnp\/pyy044","article-title":"Behavioral and Serotonergic Changes in the Frontal Cortex following Methamphetamine Self-Administration","volume":"21","author":"McFadden","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4172\/2476-2067.1000116","article-title":"The Persistent Neurotoxic Effects of Methamphetamine on Dopaminergic and Serotonergic Markers in Male and Female Rats","volume":"2","author":"McFadden","year":"2016","journal-title":"Toxicol. Open Access"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuropharm.2015.01.013","article-title":"Prior methamphetamine self-administration attenuates the dopaminergic deficits caused by a subsequent methamphetamine exposure","volume":"93","author":"McFadden","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1021\/cn500262x","article-title":"Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate","volume":"6","author":"Calipari","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/cn5002705","article-title":"Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration","volume":"6","author":"Siciliano","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2008.05.028","article-title":"Differential regional effects of methamphetamine on dopamine transport","volume":"590","author":"Chu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejphar.2009.01.037","article-title":"Methamphetamine-induced dopaminergic deficits and refractoriness to subsequent treatment","volume":"607","author":"Hanson","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_28","first-page":"312","article-title":"Release of dopamine via the human transporter","volume":"45","author":"Eshleman","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Han, D.D., and Gu, H.H. (2006). Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol., 6.","DOI":"10.1186\/1471-2210-6-6"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1073\/pnas.95.7.4029","article-title":"Profound neuronal plasticity in response to inactivation of the dopamine transporter","volume":"95","author":"Jones","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1523\/JNEUROSCI.18-06-01979.1998","article-title":"Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter","volume":"18","author":"Jones","year":"1998","journal-title":"J Neurosci"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/npp.2017.291","article-title":"Methamphetamine Induces Dopamine Release in the Nucleus Accumbens through a Sigma Receptor-Mediated Pathway","volume":"43","author":"Hedges","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00213-020-05459-2","article-title":"Methamphetamine increases dopamine release in the nucleus accumbens through calcium-dependent processes","volume":"237","author":"Yorgason","year":"2020","journal-title":"Psychopharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbi.2017.05.004","article-title":"HIV-1 TAT protein enhances sensitization to methamphetamine by affecting dopaminergic function","volume":"65","author":"Kesby","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3389\/fmicb.2015.01164","article-title":"The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders","volume":"6","author":"Mediouni","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/adb.12502","article-title":"Modeling human methamphetamine use patterns in mice: Chronic and binge methamphetamine exposure, reward function and neurochemistry","volume":"23","author":"Kesby","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11481-016-9699-0","article-title":"Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models","volume":"11","author":"Soontornniyomkij","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pscychresns.2016.02.009","article-title":"Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging","volume":"249","author":"McKenna","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15037","DOI":"10.1073\/pnas.1010654108","article-title":"Addiction: Beyond dopamine reward circuitry","volume":"108","author":"Volkow","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11481-017-9726-9","article-title":"Dopamine Increases CD14(+)CD16(+) Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis","volume":"12","author":"Calderon","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Coley, J.S., Calderon, T.M., Gaskill, P.J., Eugenin, E.A., and Berman, J.W. (2015). Dopamine increases CD14+CD16+ monocyte migration and adhesion in the context of substance abuse and HIV neuropathogenesis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117450"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Gaskill, P.J., Yano, H.H., Kalpana, G.V., Javitch, J.A., and Berman, J.W. (2014). Dopamine receptor activation increases HIV entry into primary human macrophages. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108232"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11481-013-9443-y","article-title":"Drug induced increases in CNS dopamine alter monocyte, macrophage and T cell functions: Implications for HAND","volume":"8","author":"Gaskill","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Basova, L., Najera, J.A., Bortell, N., Wang, D., Moya, R., Lindsey, A., Semenova, S., Ellis, R.J., and Marcondes, M.C.G. (2018). Dopamine and its receptors play a role in the modulation of CCR5 expression in innate immune cells following exposure to Methamphetamine: Implications to HIV infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199861"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1742-2094-9-203","article-title":"Characterization and function of the human macrophage dopaminergic system: Implications for CNS disease and drug abuse","volume":"9","author":"Gaskill","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.it.2003.09.002","article-title":"Unravelling dopamine (and catecholamine) physiopharmacology in lymphocytes: Open questions","volume":"24","author":"Cosentino","year":"2003","journal-title":"Trends Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2016.07.008","article-title":"Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis","volume":"298","author":"Cosentino","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrneurol.2016.33","article-title":"Multiple sclerosis: Repurposing dopaminergic drugs for MS\u2014The evidence mounts","volume":"12","author":"Marino","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Leite, F., Lima, M., Marino, F., Cosentino, M., and Ribeiro, L. (2016). Dopaminergic Receptors and Tyrosine Hydroxylase Expression in Peripheral Blood Mononuclear Cells: A Distinct Pattern in Central Obesity. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0147483"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nbd.2017.04.015","article-title":"HIV, Tat and dopamine transmission","volume":"105","author":"Gaskill","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.3313729","article-title":"Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line","volume":"238","author":"Folks","year":"1987","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/07388550802688847","article-title":"Multiplexed microbead immunoassays by flow cytometry for molecular profiling: Basic concepts and proteomics applications","volume":"29","author":"Krishhan","year":"2009","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.mie.2019.06.001","article-title":"LEGENDplex: Bead-assisted multiplex cytokine profiling by flow cytometry","volume":"629","author":"Lehmann","year":"2019","journal-title":"Methods Enzymol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lehmann, J.S., Zhao, A., Sun, B., Jiang, W., and Ji, S. (2017). Multiplex Cytokine Profiling of Stimulated Mouse Splenocytes Using a Cytometric Bead-based Immunoassay Platform. J. Vis. Exp., 56440.","DOI":"10.3791\/56440-v"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1093\/bioinformatics\/btq562","article-title":"GeneMANIA Cytoscape plugin: Fast gene function predictions on the desktop","volume":"26","author":"Montojo","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Donaldson","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/13803390490510031","article-title":"Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection","volume":"26","author":"Carey","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0002-9440(10)64336-2","article-title":"Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS","volume":"162","author":"Roberts","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-0-12-385493-3.00010-3","article-title":"Immunophenotypic pattern of myeloid populations by flow cytometry analysis","volume":"103","author":"Gorczyca","year":"2011","journal-title":"Methods Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1800128","DOI":"10.1002\/bies.201800128","article-title":"HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?","volume":"41","author":"Jiang","year":"2019","journal-title":"Bioessays"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3389\/fimmu.2018.01593","article-title":"CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions","volume":"9","author":"Amici","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1096\/fasebj.13.15.2265","article-title":"Effects of the human CD38 glycoprotein on the early stages of the HIV-1 replication cycle","volume":"13","author":"Savarino","year":"1999","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/QAD.0b013e3282f4de23","article-title":"Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands","volume":"22","author":"Meier","year":"2008","journal-title":"AIDS"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00042560-199712010-00002","article-title":"Elevated serum macrophage inhibitory factor-related protein (MRP) 8\/14 levels in advanced HIV infection and during disease exacerbation","volume":"16","author":"Strasser","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/infdis\/jiv028","article-title":"Myeloid-related protein 14 promotes inflammation and injury in meningitis","volume":"212","author":"Wache","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12974-018-1296-0","article-title":"Hippocampal Mrp8\/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice","volume":"15","author":"Gong","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2840-5-6","article-title":"Increased proinflammatory endothelial response to S100A8\/A9 after preactivation through advanced glycation end products","volume":"5","author":"Ehlermann","year":"2006","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Basova, L., Lindsey, A., McGovern, A.M., Ellis, R.J., and Marcondes, M.C.G. (2021). Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis. Viruses, 13.","DOI":"10.3390\/v13040544"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000028098","article-title":"The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes","volume":"67","author":"Kerkhoff","year":"1999","journal-title":"Pathobiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0167-4889(98)00144-X","article-title":"Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)","volume":"1448","author":"Kerkhoff","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/ar2645","article-title":"Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis","volume":"11","author":"Chen","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4049\/jimmunol.1401085","article-title":"Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8","volume":"194","author":"Fassl","year":"2015","journal-title":"J. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI58642","article-title":"A multimodal RAGE-specific inhibitor reduces amyloid beta-mediated brain disorder in a mouse model of Alzheimer disease","volume":"122","author":"Deane","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fmicb.2015.00900","article-title":"Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system","volume":"6","author":"Bortell","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Najera, J.A., Bustamante, E.A., Bortell, N., Morsey, B., Fox, H.S., Ravasi, T., and Marcondes, M.C. (2016). Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets. BMC Immunol., 17.","DOI":"10.1186\/s12865-016-0145-0"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbrc.2006.08.066","article-title":"Regulation of SIRT 1 mediated NAD dependent deacetylation: A novel role for the multifunctional enzyme CD38","volume":"349","author":"Aksoy","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbrc.2006.05.042","article-title":"Regulation of intracellular levels of NAD: A novel role for CD38","volume":"345","author":"Aksoy","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e0017122","DOI":"10.1128\/mcb.00171-22","article-title":"Upregulation of PD-L1 in Senescence and Aging","volume":"42","author":"Onorati","year":"2022","journal-title":"Mol. Cell. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Basova, L.V., Kesby, J.P., Kaul, M., Semenova, S., and Marcondes, M.C.G. (2020). Systems Biology Analysis of the Antagonizing Effects of HIV-1 Tat Expression in the Brain over Transcriptional Changes Caused by Methamphetamine Sensitization. Viruses, 12.","DOI":"10.3390\/v12040426"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.ajpath.2011.01.023","article-title":"Recently infiltrating MAC387(+) monocytes\/macrophages a third macrophage population involved in SIV and HIV encephalitic lesion formation","volume":"178","author":"Soulas","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2249.1995.tb08346.x","article-title":"Serum 27E10 antigen: A new potential marker for staging HIV disease","volume":"101","author":"Lugering","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.4049\/jimmunol.169.6.3307","article-title":"HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes","volume":"169","author":"Ryckman","year":"2002","journal-title":"J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1038\/s41467-022-33401-x","article-title":"S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo","volume":"13","author":"Real","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00002030-200103090-00002","article-title":"Myeloid-related protein (MRP)-8 from cervico-vaginal secretions activates HIV replication","volume":"15","author":"Hashemi","year":"2001","journal-title":"AIDS"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1089\/aid.2006.22.788","article-title":"Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load","volume":"22","author":"Cummins","year":"2006","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/aid.2021.0193","article-title":"Short Communication: S100A8 and S100A9, Biomarkers of SARS-CoV-2 Infection and Other Diseases, Suppress HIV Replication in Primary Macrophages","volume":"38","author":"Oguariri","year":"2022","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/00365549109024294","article-title":"Calprotectin in cerebrospinal fluid of the HIV infected: A diagnostic marker of opportunistic central nervous system infection?","volume":"23","author":"Dunlop","year":"1991","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbamcr.2008.11.016","article-title":"Binding of S100 proteins to RAGE: An update","volume":"1793","author":"Leclerc","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/carcin\/bgn188","article-title":"RAGE, carboxylated glycans and S100A8\/A9 play essential roles in colitis-associated carcinogenesis","volume":"29","author":"Turovskaya","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"C145","DOI":"10.1152\/ajpcell.00350.2007","article-title":"AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation","volume":"294","author":"Cai","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Villegas-Rodriguez, M.E., Uribarri, J., Solorio-Meza, S.E., Fajardo-Araujo, M.E., Cai, W., Torres-Graciano, S., Rangel-Salazar, R., Wrobel, K., and Garay-Sevilla, M.E. (2016). The AGE-RAGE Axis and Its Relationship to Markers of Cardiovascular Disease in Newly Diagnosed Diabetic Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159175"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"105083","DOI":"10.1016\/j.phrs.2020.105083","article-title":"The importance of BDNF and RAGE in diabetes-induced dementia","volume":"160","author":"Kim","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1523\/JNEUROSCI.4878-07.2008","article-title":"Site-specific blockade of RAGE-Vd prevents amyloid-beta oligomer neurotoxicity","volume":"28","author":"Sturchler","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.112.195511","article-title":"Hypertension induces brain beta-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature","volume":"60","author":"Carnevale","year":"2012","journal-title":"Hypertension"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/exnr.2001.7732","article-title":"Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer\u2019s disease: Identification of a cellular activation mechanism","volume":"171","author":"Lue","year":"2001","journal-title":"Exp. Neurol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2217\/14796708.4.2.167","article-title":"Receptor for advanced glycation end products: Its role in Alzheimer\u2019s disease and other neurological diseases","volume":"4","author":"Lue","year":"2009","journal-title":"Future Neurol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1568007054038210","article-title":"Preventing activation of receptor for advanced glycation endproducts in Alzheimer\u2019s disease","volume":"4","author":"Lue","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/13543784.2015.1001490","article-title":"Receptor for advanced glycation endproduct modulators: A new therapeutic target in Alzheimer\u2019s disease","volume":"24","author":"Walker","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.4049\/jimmunol.0803013","article-title":"Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier","volume":"182","author":"Li","year":"2009","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.atherosclerosis.2011.08.003","article-title":"Low plasma levels of the soluble receptor for advanced glycation end products in HIV-infected patients with subclinical carotid atherosclerosis receiving combined antiretroviral therapy","volume":"219","author":"Jeong","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.4049\/jimmunol.0902517","article-title":"Advanced glycation end products inhibit both infection and transmission in trans of HIV-1 from monocyte-derived dendritic cells to autologous T cells","volume":"186","author":"Nasreddine","year":"2011","journal-title":"J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1474-9726.2010.00573.x","article-title":"Biomarkers of aging in Drosophila","volume":"9","author":"Jacobson","year":"2010","journal-title":"Aging Cell"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0047-6374(97)00146-2","article-title":"Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster","volume":"100","author":"Oudes","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.bbadis.2018.08.036","article-title":"Mechanistic targeting of advanced glycation end-products in age-related diseases","volume":"1864","author":"Rowan","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"101546","DOI":"10.1016\/j.redox.2020.101546","article-title":"Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson\u2019s and Alzheimer\u2019s disease","volume":"34","author":"Sharma","year":"2020","journal-title":"Redox Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0304-4165(97)00052-4","article-title":"Mutual interaction between glycation and oxidation during non-enzymatic protein modification","volume":"1336","author":"Traverso","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Filosevic Vujnovic, A., Jovic, K., Pistan, E., and Andretic Waldowski, R. (2021). Influence of Dopamine on Fluorescent Advanced Glycation End Products Formation Using Drosophila melanogaster. Biomolecules, 11.","DOI":"10.3390\/biom11030453"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s004010050938","article-title":"Widespread expression of MRP8 and MRP14 in human cerebral malaria by microglial cells","volume":"96","author":"Schluesener","year":"1998","journal-title":"Acta Neuropathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1136\/ard.2011.152496","article-title":"MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes","volume":"70","author":"Wittkowski","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jneuroim.2003.11.005","article-title":"Monocyte activation and disease activity in multiple sclerosis. A longitudinal analysis of serum MRP8\/14 levels","volume":"148","author":"Floris","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3892\/ijmm.2017.2987","article-title":"Proinflammatory effects of S100A8\/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells","volume":"40","author":"Ma","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.celrep.2014.11.020","article-title":"Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions","volume":"9","author":"Austermann","year":"2014","journal-title":"Cell Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/emboj.2012.309","article-title":"The alarmin Mrp8\/14 as regulator of the adaptive immune response during allergic contact dermatitis","volume":"32","author":"Petersen","year":"2013","journal-title":"EMBO J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"109229","DOI":"10.1016\/j.biopha.2019.109229","article-title":"Myeloid related protein 8\/14 is a new candidate biomarker and therapeutic target for abdominal aortic aneurysm","volume":"118","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Nair, S.C., Welsing, P.M., Choi, I.Y., Roth, J., Holzinger, D., Bijlsma, J.W., van Laar, J.M., Gerlag, D.M., Lafeber, F.P., and Tak, P.P. (2016). A Personalized Approach to Biological Therapy Using Prediction of Clinical Response Based on MRP8\/14 Serum Complex Levels in Rheumatoid Arthritis Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152362"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s004390050166","article-title":"The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus","volume":"98","author":"Chang","year":"1996","journal-title":"Hum. Genet."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ajmg.b.31208","article-title":"Association between polymorphisms of DRD2 and DRD4 and opioid dependence: Evidence from the current studies","volume":"156B","author":"Chen","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1073\/pnas.012464099","article-title":"Evidence of positive selection acting at the human dopamine receptor D4 gene locus","volume":"99","author":"Ding","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/358149a0","article-title":"Multiple dopamine D4 receptor variants in the human population","volume":"358","author":"Wu","year":"1992","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.immuni.2019.10.002","article-title":"Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung","volume":"51","author":"Wang","year":"2019","journal-title":"Immunity"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mcn.2005.01.003","article-title":"Dopamine and noradrenaline control distinct functions in rodent microglial cells","volume":"29","author":"Farber","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fncel.2018.00309","article-title":"Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine","volume":"12","author":"Fan","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbi.2017.02.013","article-title":"Dopamine modulates astroglial and microglial activity via glial renin-angiotensin system in cultures","volume":"62","author":"Guerra","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","article-title":"Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome","volume":"160","author":"Yan","year":"2015","journal-title":"Cell"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"107492","DOI":"10.1016\/j.addbeh.2022.107492","article-title":"Increases in methamphetamine injection among treatment admissions in the U.S","volume":"136","author":"Jones","year":"2023","journal-title":"Addict. Behav."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1212\/01.wnl.0000240066.02404.e6","article-title":"Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users","volume":"67","author":"Chana","year":"2006","journal-title":"Neurology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1176\/appi.ajp.162.2.361","article-title":"Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities","volume":"162","author":"Chang","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03033915","article-title":"Interactions of HIV and methamphetamine: Cellular and molecular mechanisms of toxicity potentiation","volume":"12","author":"Cadet","year":"2007","journal-title":"Neurotox. Res."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/6\/1363\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:53:46Z","timestamp":1760126026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/6\/1363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":132,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["v15061363"],"URL":"https:\/\/doi.org\/10.3390\/v15061363","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}