{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T08:39:13Z","timestamp":1772440753465,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Research Career Development Grant, Thailand Research Fund","doi-asserted-by":"publisher","award":["RSA6180052"],"award-info":[{"award-number":["RSA6180052"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Viruses"],"abstract":"<jats:p>Metagenomics has demonstrated its capability in outbreak investigations and pathogen surveillance and discovery. With high-throughput and effective bioinformatics, many disease-causing agents, as well as novel viruses of humans and animals, have been identified using metagenomic analysis. In this study, a VIDISCA metagenomics workflow was used to identify potential unknown viruses in 33 fecal samples from asymptomatic long-tailed macaques (Macaca fascicularis) in Ratchaburi Province, Thailand. Putatively novel astroviruses, enteroviruses, and adenoviruses were detected and confirmed by PCR analysis of long-tailed macaque fecal samples collected from areas in four provinces, Ratchaburi, Kanchanaburi, Lopburi, and Prachuap Khiri Khan, where humans and monkeys live in proximity (total n = 187). Astroviruses, enteroviruses, and adenoviruses were present in 3.2%, 7.5%, and 4.8% of macaque fecal samples, respectively. One adenovirus, named AdV-RBR-6-3, was successfully isolated in human cell culture. Whole-genome analysis suggested that it is a new member of the species Human adenovirus G, closely related to Rhesus adenovirus 53, with evidence of genetic recombination and variation in the hexon, fiber, and CR1 genes. Sero-surveillance showed neutralizing antibodies against AdV-RBR-6-3 in 2.9% and 11.2% of monkeys and humans, respectively, suggesting cross-species infection of monkeys and humans. Overall, we reported the use of metagenomics to screen for possible new viruses, as well as the isolation and molecular and serological characterization of the new adenovirus with cross-species transmission potential. The findings emphasize that zoonotic surveillance is important and should be continued, especially in areas where humans and animals interact, to predict and prevent the threat of emerging zoonotic pathogens.<\/jats:p>","DOI":"10.3390\/v15061371","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:32:57Z","timestamp":1686792777000},"page":"1371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Novel Simian Adenovirus Associating with Human Adenovirus Species G Isolated from Long-Tailed Macaque Feces"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-0696","authenticated-orcid":false,"given":"Nathamon","family":"Kosoltanapiwat","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-642X","authenticated-orcid":false,"given":"Lia","family":"van der Hoek","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-4608","authenticated-orcid":false,"given":"Cormac","family":"Kinsella","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarinee","family":"Tongshoob","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxsana","family":"Prasittichai","sequence":"additional","affiliation":[{"name":"Wildlife Conservation Division, Protected Areas Regional Office 3 (Ban Pong), Department of National Parks, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Ratchaburi 70110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-991X","authenticated-orcid":false,"given":"Michelle","family":"Klein","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Jebbink","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Deijs","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1154-6485","authenticated-orcid":false,"given":"Onrapak","family":"Reamtong","sequence":"additional","affiliation":[{"name":"Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-8964","authenticated-orcid":false,"given":"Kobporn","family":"Boonnak","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wathusiri","family":"Khongsiri","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-0144","authenticated-orcid":false,"given":"Juthamas","family":"Phadungsombat","sequence":"additional","affiliation":[{"name":"Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daraka","family":"Tongthainan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Rajamangala University of Technology Tawan-ok, Chonburi 20110, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-1497","authenticated-orcid":false,"given":"Phitsanu","family":"Tulayakul","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom 73140, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnoch","family":"Yindee","sequence":"additional","affiliation":[{"name":"Akkhraratchakumari Veterinary College, Walailak University, Nakhonsithammarat 80161, 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Rev. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0684.2006.00167.x","article-title":"Detection of viral agents in fecal specimens of monkeys with diarrhea","volume":"36","author":"Wang","year":"2007","journal-title":"J. Med. Primatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3201\/eid2302.161077","article-title":"Norovirus GII.17 natural infections in rhesus monkeys, China","volume":"23","author":"He","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e00952-17","DOI":"10.1128\/JVI.00952-17","article-title":"Case-control comparison of enteric viromes in captive rhesus macaques with acute or idiopathic chronic diarrhea","volume":"91","author":"Kapusinszky","year":"2017","journal-title":"J. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100434","DOI":"10.1016\/j.onehlt.2022.100434","article-title":"Simian adenoviruses: Molecular and serological survey in monkeys and humans in Thailand","volume":"15","author":"Kosoltanapiwat","year":"2022","journal-title":"One Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1128\/JVI.02081-09","article-title":"Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment","volume":"84","author":"Matthijnssens","year":"2010","journal-title":"J. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e00564-19","DOI":"10.1128\/JVI.00564-19","article-title":"Zoonotic adenoviral human pathogen emerged through genomic recombination among human and nonhuman simian hosts","volume":"93","author":"Dehghan","year":"2019","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/S0140-6736(12)61684-5","article-title":"Prediction and prevention of the next pandemic zoonosis","volume":"380","author":"Morse","year":"2012","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.tibtech.2013.01.016","article-title":"Metagenomic identification of viral pathogens","volume":"31","author":"Bibby","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Greninger, A.L., Chen, E.C., Sittler, T., Scheinerman, A., Roubinian, N., Yu, G., Kim, E., Pillai, D.R., Guyard, C., and Mazzulli, T. (2010). A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013381"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00827-19","DOI":"10.1128\/JCM.00827-19","article-title":"Metagenomic next-generation sequencing of the 2014 Ebola virus disease outbreak in the Democratic Republic of the Congo","volume":"57","author":"Li","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/22221751.2020.1725399","article-title":"RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak","volume":"9","author":"Chen","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00203-020-02105-5","article-title":"Potential role of viral metagenomics as a surveillance tool for the early detection of emerging novel pathogens","volume":"203","author":"Mohsin","year":"2021","journal-title":"Arch. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.coviro.2012.02.012","article-title":"Animal virus discovery: Improving animal health, understanding zoonoses, and opportunities for vaccine development","volume":"2","author":"Delwart","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.coviro.2018.12.007","article-title":"Viruses in bats and potential spillover to animals and humans","volume":"34","author":"Wang","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2022.02.014","article-title":"Virome characterization of game animals in China reveals a spectrum of emerging pathogens","volume":"185","author":"He","year":"2022","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/gm485","article-title":"Metagenomics for pathogen detection in public health","volume":"5","author":"Miller","year":"2013","journal-title":"Genome Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tracli.2015.12.002","article-title":"Viral metagenomics and blood safety","volume":"23","author":"Sauvage","year":"2016","journal-title":"Transfus. Clin. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-59745-181-9_7","article-title":"Detection of new viruses by VIDISCA. Virus discovery based on cDNA-amplified fragment length polymorphism","volume":"454","author":"Pyrc","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virusres.2018.12.010","article-title":"Enhanced bioinformatic profiling of VIDISCA libraries for virus detection and discovery","volume":"263","author":"Kinsella","year":"2019","journal-title":"Virus Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nm1024","article-title":"Identification of a new human coronavirus","volume":"10","author":"Pyrc","year":"2004","journal-title":"Nat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/cid\/ciy486","article-title":"Novel orthobunyavirus identified in the cerebrospinal fluid of a Ugandan child with severe encephalopathy","volume":"68","author":"Edridge","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Edridge, A.W.D., Abd-Elfarag, G., Deijs, M., Jebbink, M.F., Boele van Hensbroek, M., and van der Hoek, L. (2022). Divergent rhabdovirus discovered in a patient with new-onset nodding syndrome. Viruses, 14.","DOI":"10.3390\/v14020210"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Canuti, M., Eis-Huebinger, A.M., Deijs, M., de Vries, M., Drexler, J.F., Oppong, S.K., M\u00fcller, M.A., Klose, S.M., Wellinghausen, N., and Cottontail, V.M. (2011). Two novel parvoviruses in frugivorous new and old world bats. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029140"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00705-018-4099-9","article-title":"Virus discovery reveals frequent infection by diverse novel members of the Flaviviridae in wild lemurs","volume":"164","author":"Canuti","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/jcm.28.3.495-503.1990","article-title":"Rapid and simple method for purification of nucleic acids","volume":"28","author":"Boom","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/nar\/gni064","article-title":"Species-independent detection of RNA virus by representational difference analysis using non-ribosomal hexanucleotides for reverse transcription","volume":"33","author":"Endoh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kosoltanapiwat, N., Reamtong, O., Okabayashi, T., Ampawong, S., Rungruengkitkun, A., Thiangtrongjit, T., Thippornchai, N., Leaungwutiwong, P., Mahittikorn, A., and Mori, H. (2018). Mass spectrometry-based identification and whole-genome characterisation of the first pteropine orthoreovirus isolated from monkey faeces in Thailand. BMC Microbiol., 18.","DOI":"10.1186\/s12866-018-1302-9"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: A new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. Comput. Biol."},{"key":"ref_31","first-page":"95","article-title":"BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucl. Acids. Symp. Ser."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/JVI.73.1.152-160.1999","article-title":"Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination","volume":"73","author":"Lole","year":"1999","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/molbev\/msx263","article-title":"Improved algorithmic complexity for the 3SEQ recombination detection algorithm","volume":"35","author":"Lam","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lerdsamran, H., Mungaomklang, A., Iamsirithaworn, S., Prasertsopon, J., Wiriyarat, W., Saritsiri, S., Anusorntanawat, R., Siriyakorn, N., Intalapaporn, P., and Sirikhetkon, S. (2022). Seroprevalence of anti-SARS-CoV-2 antibodies in Thai adults during the first three epidemic waves. PLoS ONE, 17.","DOI":"10.1101\/2022.01.18.22269501"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s00705-019-04319-5","article-title":"A novel astrovirus identified in wild rhesus monkey feces in China","volume":"164","author":"Xin","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"28526","DOI":"10.1038\/srep28526","article-title":"Identification of a novel enterovirus species in rhesus macaque in China","volume":"6","author":"Ao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","first-page":"18","article-title":"Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species","volume":"3\u20134","author":"Malouli","year":"2014","journal-title":"Virol. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1128\/JCM.00074-08","article-title":"Identification of enteroviruses in naturally infected captive primates","volume":"46","author":"Nix","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Karlsson, E.A., Small, C.T., Freiden, P., Feeroz, M.M., Matsen, F.A., San, S., Hasan, M.K., Wang, D., Jones-Engel, L., and Schultz-Cherry, S. (2015). Non-human primates harbor diverse mammalian and avian astroviruses including those associated with human infections. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005225"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Chen, E.C., Yagi, S., Kelly, K.R., Mendoza, S.P., Tarara, R.P., Canfield, D.R., Maninger, N., Rosenthal, A., Spinner, A., and Bales, K.L. (2011). Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony. PLoS Pathog., 7.","DOI":"10.1371\/annotation\/59703f7f-9506-49d1-b339-09ee31510e89"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Liu, E.B., Ferreyra, L., Fischer, S.L., Pavan, J.V., Nates, S.V., Hudson, N.R., Tirado, D., Dyer, D.W., Chodosh, J., and Seto, D. (2011). Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024491"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/JVI.02950-14","article-title":"Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors","volume":"89","author":"Abbink","year":"2015","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e01924-17","DOI":"10.1128\/JVI.01924-17","article-title":"Rapid cloning of novel rhesus adenoviral vaccine vectors","volume":"92","author":"Abbink","year":"2018","journal-title":"J. Virol."},{"key":"ref_45","first-page":"001721","article-title":"Ictv Report Consortium. ICTV virus taxonomy profile: Adenoviridae 2022","volume":"103","author":"Aoki","year":"2022","journal-title":"J. Gen. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.1128\/JVI.02650-06","article-title":"New adenovirus species found in a patient presenting with gastroenteritis","volume":"81","author":"Jones","year":"2007","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2012.09.024","article-title":"Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome","volume":"151","author":"Handley","year":"2012","journal-title":"Cell."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1128\/JVI.79.4.2559-2572.2005","article-title":"Genomic and bioinformatics analysis of HAdV-4, a human adenovirus causing acute respiratory disease: Implications for gene therapy and vaccine vector development","volume":"79","author":"Purkayastha","year":"2005","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/cla.12422","article-title":"Genomics-based re-examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: An evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis","volume":"36","author":"Kang","year":"2020","journal-title":"Cladistics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1099\/jgv.0.000465","article-title":"Genome analysis of four Old World monkey adenoviruses supports the proposed species classification of primate adenoviruses and reveals signs of possible homologous recombination","volume":"97","author":"Podgorski","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1128\/JVI.01927-13","article-title":"Homologous recombination in E3 genes of human adenovirus species D","volume":"87","author":"Singh","year":"2013","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3390\/v4050847","article-title":"Latest insights on adenovirus structure and assembly","volume":"4","year":"2012","journal-title":"Viruses"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e2020732118","DOI":"10.1073\/pnas.2020732118","article-title":"Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46","volume":"118","author":"Persson","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.virol.2018.03.002","article-title":"Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity","volume":"518","author":"Feng","year":"2018","journal-title":"Virology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3201\/eid1210.060078","article-title":"Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa","volume":"12","author":"Xiang","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Klann, P.J., Wang, X., Elfert, A., Zhang, W., K\u00f6hler, C., G\u00fcttsches, A.K., Jacobsen, F., Weyen, U., Roos, A., and Ehrke-Schulz, E. (2022). Seroprevalence of binding and neutralizing antibodies against 39 human adenovirus types in patients with neuromuscular disorders. Viruses, 15.","DOI":"10.3390\/v15010079"}],"updated-by":[{"DOI":"10.3390\/v15091871","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000}}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/6\/1371\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T14:14:11Z","timestamp":1754230451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/6\/1371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,14]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["v15061371"],"URL":"https:\/\/doi.org\/10.3390\/v15061371","relation":{"correction":[{"id-type":"doi","id":"10.3390\/v15091871","asserted-by":"object"}]},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,14]]}}}