{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:21:15Z","timestamp":1774556475148,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68\u201322.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.<\/jats:p>","DOI":"10.3390\/v15061386","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:31:14Z","timestamp":1687138274000},"page":"1386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Isha","family":"Rani","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), Sadopur Ambala 134007, India"},{"name":"Global Center for Evidence Synthesis, Chandigarh 160036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-8587","authenticated-orcid":false,"given":"Prakasini","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Global Center for Evidence Synthesis, Chandigarh 160036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmol","family":"Goyal","sequence":"additional","affiliation":[{"name":"Global Center for Evidence Synthesis, Chandigarh 160036, India"},{"name":"Department of Community Medicine, Maharishi Markandeshwar College of Medical Sciences and Research (MMCMSR), SadopurAmbala 134007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Aaqib","family":"Shamim","sequence":"additional","affiliation":[{"name":"Global Center for Evidence Synthesis, Chandigarh 160036, India"},{"name":"Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Jodhpur 342001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-3309","authenticated-orcid":false,"given":"Amit","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Kalyani 741250, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5624-1140","authenticated-orcid":false,"given":"Rosanna","family":"Squitti","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science, Research and Development Division, Fatebenefratelli Isola Tiberina, Gemelli Isola, 00186 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyan","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Kalyani 741250, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-6022","authenticated-orcid":false,"given":"Keerti Bhusan","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Healthcare Management, Chitkara School of Health Sciences, Chitkara University Punjab, Patiala 140401, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1247-1040","authenticated-orcid":false,"given":"Sarvesh","family":"Rustagi","sequence":"additional","affiliation":[{"name":"School of Applied and Life Sciences, Dehradun 180004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Hamza","family":"Hermis","sequence":"additional","affiliation":[{"name":"Nursing Department, Al-Mustaqbal University College, Hillah 51001, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshuan J.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad C\u00e9sar Vallejo, Trujillo 13007, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2192","authenticated-orcid":false,"given":"Alfonso J.","family":"Rodriguez-Morales","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Biostatistics, School of Medicine, Universidad Cient\u00edfica del Sur, Lima 4861, Peru"},{"name":"Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut P.O. Box 36, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Tribhuvan University Teaching Hospital, Kathmandu 44600, Nepal"},{"name":"Department of Clinical Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune 411000, India"},{"name":"Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. 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