{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:29:30Z","timestamp":1792024170283,"version":"4.4.0"},"reference-count":100,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Growth Technology Project of Jilin Provincial Science and Technology Development Program","award":["20210508019RQ"],"award-info":[{"award-number":["20210508019RQ"]}]},{"name":"Youth Growth Technology Project of Jilin Provincial Science and Technology Development Program","award":["2202034A"],"award-info":[{"award-number":["2202034A"]}]},{"name":"Core Technical Public Welfare Project of Luoyang, China","award":["20210508019RQ"],"award-info":[{"award-number":["20210508019RQ"]}]},{"name":"Core Technical Public Welfare Project of Luoyang, China","award":["2202034A"],"award-info":[{"award-number":["2202034A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Since its discovery, Porcine reproductive and respiratory syndrome (PRRS) has had a huge impact on the farming industry. The virus that causes PRRS is Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), and because of its genetic diversity and the complexity of the immune response, the eradication of PRRS has been a challenge. To provide scientific references for PRRSV control and vaccine development, this study describes the processes of PRRSV-induced infection and escape, as well as the host adaptive immune response to PRRSV. It also discusses the relationship between PRRSV and the adaptive immune response.<\/jats:p>","DOI":"10.3390\/v15071442","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T01:42:02Z","timestamp":1687830122000},"page":"1442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Progress in PRRSV Infection and Adaptive Immune Response Mechanisms"],"prefix":"10.3390","volume":"15","author":[{"given":"Huanchang","family":"Cai","sequence":"first","affiliation":[{"name":"Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food and Drugs, Luoyang Polytechnic, Luoyang 471099, China"},{"name":"Animal Diseases and Public Health Engineering Research Center of Henan Province, Luoyang 471000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Wen","sequence":"additional","affiliation":[{"name":"Preventive Veterinary Laboratory, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0166-4445","authenticated-orcid":false,"given":"Jingqiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou 325035, China"},{"name":"Animal Diseases and Public Health Engineering Research Center of Henan Province, Luoyang 471000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/01652176.1991.9694296","article-title":"Mystery swine disease in The Netherlands: The isolation of Lelystad virus","volume":"13","author":"Wensvoort","year":"1991","journal-title":"Vet. Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/104063879200400201","article-title":"Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs","volume":"4","author":"Collins","year":"1992","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"109168","DOI":"10.1016\/j.vetmic.2021.109168","article-title":"The jigsaw of PRRSV virulence","volume":"260","author":"Carrasco","year":"2021","journal-title":"Vet. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.virusres.2010.07.029","article-title":"The structural biology of PRRSV","volume":"154","author":"Dokland","year":"2010","journal-title":"Virus Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1128\/jcm.31.12.3184-3189.1993","article-title":"Differentiation of U.S. and European isolates of porcine reproductive and respiratory syndrome virus by monoclonal antibodies","volume":"31","author":"Nelson","year":"1993","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e01813-19","DOI":"10.1128\/JVI.01813-19","article-title":"Phylogenetics, Genomic Recombination, and NSP2 Polymorphic Patterns of Porcine Reproductive and Respiratory Syndrome Virus in China and the United States in 2014\u20132018","volume":"94","author":"Yu","year":"2020","journal-title":"J. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1067173","DOI":"10.3389\/fmicb.2022.1067173","article-title":"Epidemiological investigation and genetic evolutionary analysis of PRRSV-1 on a pig farm in China","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Yu, F., Liu, L., Tian, X., Chen, L., Huang, X., Sun, Y., Yan, Y., Tian, Z., Cai, X., and Liu, D. (2022). Genomic Analysis of Porcine Reproductive and Respiratory Syndrome Virus 1 Revealed Extensive Recombination and Potential Introduction Events in China. Vet. Sci., 9.","DOI":"10.3390\/vetsci9090450"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhao, J., Xu, Z., Xu, T., Zhou, Y., Li, J., Deng, H., Li, F., Xu, L., Sun, X., and Zhu, L. (2022). Molecular Characterization of the Nsp2 and ORF5s of PRRSV Strains in Sichuan China during 2012\u20132020. Animals, 12.","DOI":"10.3390\/ani12233309"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.4049\/jimmunol.181.9.5829","article-title":"Macrophages as APC and the dendritic cell myth","volume":"181","author":"Hume","year":"2008","journal-title":"J. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1016\/j.vaccine.2011.09.013","article-title":"Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)","volume":"29","author":"Murtaugh","year":"2011","journal-title":"Vaccine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.tim.2017.06.001","article-title":"Antiviral Strategies against PRRSV Infection","volume":"25","author":"Du","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-animal-022114-111025","article-title":"Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System","volume":"4","author":"Lunney","year":"2016","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vetmic.2003.07.006","article-title":"Lymphoid tissue tropism of porcine reproductive and respiratory syndrome virus replication during persistent infection of pigs originally exposed to virus in utero","volume":"96","author":"Rowland","year":"2003","journal-title":"Vet. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"198885","DOI":"10.1016\/j.virusres.2022.198885","article-title":"PRRS virus receptors and an alternative pathway for viral invasion","volume":"320","author":"Ye","year":"2022","journal-title":"Virus. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhang, H., Sha, H., Qin, L., Wang, N., Kong, W., Huang, L., and Zhao, M. (2022). Research Progress in Porcine Reproductive and Respiratory Syndrome Virus-Host Protein Interactions. Animals, 12.","DOI":"10.3390\/ani12111381"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e00574-19","DOI":"10.1128\/mBio.00574-19","article-title":"Nonmuscle Myosin Heavy Chain IIA Recognizes Sialic Acids on Sialylated RNA Viruses to Suppress Proinflammatory Responses via the DAP12-Syk Pathway","volume":"10","author":"Liu","year":"2019","journal-title":"mBio"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e0186021","DOI":"10.1128\/spectrum.01860-21","article-title":"Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"865343","DOI":"10.3389\/fmicb.2022.865343","article-title":"Identification of MYH9 Key Domain Involved in the Entry of PRRSV Into Permissive Cells","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3389\/fmicb.2019.01815","article-title":"Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells","volume":"10","author":"Hou","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Van Breedam, W., Van Gorp, H., Zhang, J.Q., Crocker, P.R., Delputte, P.L., and Nauwynck, H.J. (2010). The M\/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000730"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/JVI.01774-09","article-title":"The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163","volume":"84","author":"Das","year":"2010","journal-title":"J. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/JVI.80.2.689-696.2006","article-title":"Defining the cellular target(s) of porcine reproductive and respiratory syndrome virus blocking monoclonal antibody 7G10","volume":"80","author":"Kim","year":"2006","journal-title":"J. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109133","DOI":"10.1016\/j.vetmic.2021.109133","article-title":"Vimentin rearrangement by phosphorylation is beneficial for porcine reproductive and respiratory syndrome virus replication in vitro","volume":"259","author":"Zheng","year":"2021","journal-title":"Vet. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e00709-20","DOI":"10.1128\/JVI.00709-20","article-title":"Porcine Reproductive and Respiratory Syndrome Virus Utilizes Viral Apoptotic Mimicry as an Alternative Pathway to Infect Host Cells","volume":"94","author":"Wei","year":"2020","journal-title":"J. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.3389\/fmicb.2019.03115","article-title":"CD163(\u0394SRCR5) MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 with Calpain 1","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e01521-16","DOI":"10.1128\/JVI.01521-16","article-title":"Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus","volume":"91","author":"Wells","year":"2017","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"JVI.00415-18","DOI":"10.1128\/JVI.00415-18","article-title":"Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection","volume":"92","author":"Burkard","year":"2018","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"001740","DOI":"10.1099\/jgv.0.001740","article-title":"Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS)","volume":"103","author":"Stoian","year":"2022","journal-title":"J. Gen. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jviromet.2009.11.003","article-title":"Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus","volume":"163","author":"Lee","year":"2010","journal-title":"J. Virol. Methods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.vetmic.2015.11.016","article-title":"Replication characteristics of eight virulent and two attenuated genotype 1 and 2 porcine reproductive and respiratory syndrome virus (PRRSV) strains in nasal mucosa explants","volume":"182","author":"Frydas","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2300288","DOI":"10.1002\/advs.202300288","article-title":"Nano-LYTACs for Degradation of Membrane Proteins and Inhibition of CD24\/Siglec-10 Signaling Pathway","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-1135(96)01337-5","article-title":"Porcine reproductive and respiratory syndrome virus: A persistent infection","volume":"55","author":"Wills","year":"1997","journal-title":"Vet. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1865-1682.2011.01306.x","article-title":"Challenges and opportunities for the control and elimination of porcine reproductive and respiratory syndrome virus","volume":"59","author":"Rowland","year":"2012","journal-title":"Transbound Emerg. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13028-022-00630-5","article-title":"Elimination of porcine reproductive and respiratory syndrome virus infection using an inactivated vaccine in combination with a roll-over method in a Hungarian large-scale pig herd","volume":"64","author":"Pertich","year":"2022","journal-title":"Acta Vet. Scand."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/bs.aivir.2020.09.002","article-title":"Viral cell-to-cell spread: Conventional and non-conventional ways","volume":"108","author":"Dutch","year":"2020","journal-title":"Adv. Virus Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.virol.2017.12.018","article-title":"Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus","volume":"517","author":"Guo","year":"2018","journal-title":"Virology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1128\/JVI.00036-16","article-title":"Porcine Reproductive and Respiratory Syndrome Virus Utilizes Nanotubes for Intercellular Spread","volume":"90","author":"Guo","year":"2016","journal-title":"J. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Chen, X.X., Zhou, X., Guo, T., Qiao, S., Guo, Z., Li, R., Jin, Q., Hu, X., Xing, G., and Deng, R. (2021). Efficacy of a live attenuated highly pathogenic PRRSV vaccine against a NADC30-like strain challenge: Implications for ADE of PRRSV. BMC Vet. Res., 17.","DOI":"10.1186\/s12917-021-02957-z"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"108655","DOI":"10.1016\/j.vetmic.2020.108655","article-title":"Immune response and protective efficacy of intramuscular and intradermal vaccination with porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) modified live vaccine against highly pathogenic PRRSV-2 (HP-PRRSV-2) challenge, either alone or in combination with of PRRSV-1","volume":"244","author":"Madapong","year":"2020","journal-title":"Vet. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e0257421","DOI":"10.1128\/spectrum.02574-21","article-title":"Systemic Homologous Neutralizing Antibodies Are Inadequate for the Evaluation of Vaccine Protective Efficacy against Coinfection by High Virulent PEDV and PRRSV","volume":"10","author":"Qiu","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e00045-19","DOI":"10.1128\/JVI.00045-19","article-title":"Intrahost Selection Pressure Drives Equine Arteritis Virus Evolution during Persistent Infection in the Stallion Reproductive Tract","volume":"93","author":"Nam","year":"2019","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tim.2019.10.009","article-title":"Effects of PRRSV Infection on the Porcine Thymus","volume":"28","author":"Wang","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rahe, M.C., and Murtaugh, M.P. (2017). Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus. Viruses, 9.","DOI":"10.3390\/v9060148"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"960709","DOI":"10.3389\/fimmu.2022.960709","article-title":"Integrated time-series transcriptomic and metabolomic analyses reveal different inflammatory and adaptive immune responses contributing to host resistance to PRRSV","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2015.07.003","article-title":"Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus","volume":"167","author":"Loving","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tian, Y., Hao, Y., Dong, M., Li, S., Wang, D., Jiang, F., Wang, Q., Hao, X., Yang, Y., and Chen, N. (2022). Development of a Monoclonal Antibody to Pig CD69 Reveals Early Activation of T Cells in Pig after PRRSV and ASFV Infection. Viruses, 14.","DOI":"10.3390\/v14061343"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"773146","DOI":"10.3389\/fimmu.2021.773146","article-title":"Activation of T-bet, FOXP3, and EOMES in Target Organs from Piglets Infected with the Virulent PRRSV-1 Lena Strain","volume":"12","author":"Barranco","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kick, A.R., Amaral, A.F., Cortes, L.M., Fogle, J.E., Crisci, E., Almond, G.W., and K\u00e4ser, T. (2019). The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Viruses, 11.","DOI":"10.3390\/v11090796"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1020227","DOI":"10.3389\/fimmu.2022.1020227","article-title":"Systemic CD4 cytotoxic T cells improve protection against PRRSV-1 transplacental infection","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.vetmic.2013.03.001","article-title":"Suppression of NK cell-mediated cytotoxicity against PRRSV-infected porcine alveolar macrophages in vitro","volume":"164","author":"Cao","year":"2013","journal-title":"Vet. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Crisci, E., Fraile, L., and Montoya, M. (2019). Cellular Innate Immunity against PRRSV and Swine Influenza Viruses. Vet. Sci., 6.","DOI":"10.3390\/vetsci6010026"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1128\/JVI.78.11.5923-5933.2004","article-title":"The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load","volume":"78","author":"Xiao","year":"2004","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vetmic.2018.01.014","article-title":"Induction of porcine reproductive and respiratory syndrome virus (PRRSV)-specific regulatory T lymphocytes (Treg) in the lungs and tracheobronchial lymph nodes of PRRSV-infected pigs","volume":"216","author":"Nedumpun","year":"2018","journal-title":"Vet. Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fimmu.2019.00579","article-title":"Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions","volume":"10","author":"Nedumpun","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e0105221","DOI":"10.1128\/JVI.01052-21","article-title":"Porcine Reproductive and Respiratory Syndrome Virus Infection Upregulates Negative Immune Regulators and T-Cell Exhaustion Markers","volume":"95","author":"Chaudhari","year":"2021","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"671743","DOI":"10.3389\/fimmu.2021.671743","article-title":"Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion","volume":"12","author":"Carrasco","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_58","first-page":"1007523","article-title":"PRRSV-1 induced lung lesion is associated with an imbalance between costimulatory and coinhibitory immune checkpoints","volume":"13","author":"Carrasco","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s007050050489","article-title":"T cell responses to the structural polypeptides of porcine reproductive and respiratory syndrome virus","volume":"144","author":"Bautista","year":"1999","journal-title":"Arch. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chung, C.J., Cha, S.H., Grimm, A.L., Ajithdoss, D., Rzepka, J., Chung, G., Yu, J., Davis, W.C., and Ho, C.S. (2018). Pigs that recover from porcine reproduction and respiratory syndrome virus infection develop cytotoxic CD4+CD8+ and CD4+CD8- T-cells that kill virus infected cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203482"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.3389\/fimmu.2019.02995","article-title":"Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I)","volume":"10","author":"Pan","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1099\/jgv.0.001492","article-title":"Construction and efficacy evaluation of novel swine leukocyte antigen (SLA) class I and class II allele-specific poly-T cell epitope vaccines against porcine reproductive and respiratory syndrome virus","volume":"101","author":"Tian","year":"2020","journal-title":"J. Gen. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"109131","DOI":"10.1016\/j.vetmic.2021.109131","article-title":"Identification of potential SLA-I-restricted CTL epitopes within the M protein of porcine reproductive and respiratory syndrome virus","volume":"259","author":"Liang","year":"2021","journal-title":"Vet. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.virol.2019.09.006","article-title":"Cytotoxic T lymphocyte epitopes identified from a contemporary strain of porcine reproductive and respiratory syndrome virus enhance CD4+CD8+ T, CD8+ T, and \u03b3\u03b4 T cell responses","volume":"538","author":"Cao","year":"2019","journal-title":"Virology"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"M\u00f6tz, M., Stas, M.R., Hammer, S.E., Duckova, T., Fontaine, F., Kiesler, A., Seitz, K., Ladinig, A., M\u00fcller, A.C., and Riedel, C. (2022). Identification of MHC-I-Presented Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) Peptides Reveals Immunogenic Epitopes within Several Non-Structural Proteins Recognized by CD8(+) T Cells. Viruses, 14.","DOI":"10.3390\/v14091891"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"110237","DOI":"10.1016\/j.vetimm.2021.110237","article-title":"Mannosylated gelatin nanoparticles enhanced inactivated PRRSV targeting dendritic cells and increased T cell immunity","volume":"235","author":"Huang","year":"2021","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vetimm.2018.04.006","article-title":"Nasal delivery of chitosan\/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses","volume":"200","author":"Lee","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Welner, S., Ruggli, N., Liniger, M., Summerfield, A., Larsen, L.E., and Jungersen, G. (2021). Reduced Virus Load in Lungs of Pigs Challenged with Porcine Reproductive and Respiratory Syndrome Virus after Vaccination with Virus Replicon Particles Encoding Conserved PRRSV Cytotoxic T-Cell Epitopes. Vaccines, 9.","DOI":"10.3390\/vaccines9030208"},{"key":"ref_69","first-page":"74","article-title":"Vaccination of Mice with Listeria ivanovii Expressing the Truncated M Protein of Porcine Reproductive and Respiratory Syndrome Virus Induces both Antigen-Specific CD4+ and CD8+ T Cell-Mediated Immunity","volume":"29","author":"Tang","year":"2019","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bernelin-Cottet, C., Urien, C., Stubsrud, E., Jakob, V., Bouguyon, E., Bordet, E., Barc, C., Boulesteix, O., Contreras, V., and Barnier-Quer, C. (2019). A DNA-Modified Live Vaccine Prime-Boost Strategy Broadens the T-Cell Response and Enhances the Antibody Response against the Porcine Reproductive and Respiratory Syndrome Virus. Viruses, 11.","DOI":"10.3390\/v11060551"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e00007-18","DOI":"10.1128\/JVI.00007-18","article-title":"Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and \u03b3\u03b4 T Cell Responses and Confers Heterologous Protection","volume":"92","author":"Cao","year":"2018","journal-title":"J. Virol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fvets.2019.00038","article-title":"Key Gaps in the Knowledge of the Porcine Respiratory Reproductive Syndrome Virus (PRRSV)","volume":"6","author":"Montoya","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wang, H., Xu, Y., and Feng, W. (2021). Porcine Reproductive and Respiratory Syndrome Virus: Immune Escape and Application of Reverse Genetics in Attenuated Live Vaccine Development. Vaccines, 9.","DOI":"10.3390\/vaccines9050480"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/viro.2002.1612","article-title":"Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity","volume":"302","author":"Osorio","year":"2002","journal-title":"Virology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","article-title":"T Follicular Helper Cell Biology: A Decade of Discovery and Diseases","volume":"50","author":"Crotty","year":"2019","journal-title":"Immunity"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetimm.2004.09.005","article-title":"Role of neutralizing antibodies in PRRSV protective immunity","volume":"102","author":"Lopez","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Luo, Q., Zheng, Y., Zhang, H., Yang, Z., Sha, H., Kong, W., Zhao, M., and Wang, N. (2023). Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory Syndrome Virus. Animals, 13.","DOI":"10.3390\/ani13050813"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1128\/JVI.00189-11","article-title":"Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3","volume":"85","author":"Vu","year":"2011","journal-title":"J. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/JVI.80.8.3994-4004.2006","article-title":"Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies","volume":"80","author":"Ansari","year":"2006","journal-title":"J. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Paploski, I.A.D., Makau, D.N., Pamornchainavakul, N., Baker, J.P., Schroeder, D., Rovira, A., and VanderWaal, K. (2022). Potential Novel N-Glycosylation Patterns Associated with the Emergence of New Genetic Variants of PRRSV-2 in the U.S. Vaccines, 10.","DOI":"10.3390\/vaccines10122021"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s00705-019-04373-z","article-title":"High-frequency mutation and recombination are responsible for the emergence of novel porcine reproductive and respiratory syndrome virus in northwest China","volume":"164","author":"Zhang","year":"2019","journal-title":"Arch. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"109526","DOI":"10.1016\/j.vetmic.2022.109526","article-title":"Enhancing half-life and cytotoxicity of porcine respiratory and reproductive syndrome virus soluble receptors by taming their Fc domains","volume":"273","author":"Liu","year":"2022","journal-title":"Vet. Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, H., Li, W., Feng, X., Han, F., Zhang, Y., Chen, J., Liu, D., and Xia, P. (2022). Activating Fc Gamma Receptors and Viral Receptors Are Required for Antibody-Dependent Enhancement of Porcine Reproductive and Respiratory Syndrome Virus Infection. Vet. Sci., 9.","DOI":"10.3390\/vetsci9090470"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12250-018-0032-3","article-title":"Porcine Fc\u03b5RI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction","volume":"33","author":"Shi","year":"2018","journal-title":"Virol. Sin."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Zhang, L., Li, W., Sun, Y., Kong, L., Xu, P., Xia, P., and Zhang, G. (2020). Antibody-Mediated Porcine Reproductive and Respiratory Syndrome Virus Infection Downregulates the Production of Interferon-\u03b1 and Tumor Necrosis Factor-\u03b1 in Porcine Alveolar Macrophages via Fc Gamma Receptor I and III. Viruses, 12.","DOI":"10.3390\/v12020187"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijbiomac.2019.07.005","article-title":"Porcine Fc\u03b3RIIb mediated PRRSV ADE infection through inhibiting IFN-\u03b2 by cytoplasmic inhibitory signal transduction","volume":"138","author":"Wan","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Xu, P., Li, W., Zhao, S., Cui, Z., Chen, Y., Zhang, Y.N., Chen, J., and Xia, P. (2022). Proteomic Characterization of PAMs with PRRSV-ADE Infection. Viruses, 15.","DOI":"10.3390\/v15010036"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.vetimm.2013.09.006","article-title":"Antibody-dependent enhancement of PRRSV infection down-modulates TNF-\u03b1 and IFN-\u03b2 transcription in macrophages","volume":"156","author":"Bao","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1099\/vir.0.000118","article-title":"Involvement of CD16 in antibody-dependent enhancement of porcine reproductive and respiratory syndrome virus infection","volume":"96","author":"Gu","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Sautter, C.A., Trus, I., Nauwynck, H., and Summerfield, A. (2019). No Evidence for a Role for Antibodies during Vaccination-Induced Enhancement of Porcine Reproductive and Respiratory Syndrome. Viruses, 11.","DOI":"10.3390\/v11090829"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetimm.2017.02.002","article-title":"Effector mechanisms of humoral immunity to porcine reproductive and respiratory syndrome virus","volume":"186","author":"Rahe","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"903755","DOI":"10.3389\/fimmu.2022.903755","article-title":"Fc-Mediated Functions of Porcine IgG Subclasses","volume":"13","author":"Paudyal","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2018.07.009","article-title":"A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus","volume":"24","author":"Gunn","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.3389\/fimmu.2018.02290","article-title":"NK Cells in HIV-1 Infection: From Basic Science to Vaccine Strategies","volume":"9","author":"Hernandez","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e78294","DOI":"10.7554\/eLife.78294","article-title":"Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response","volume":"11","author":"Burgos","year":"2022","journal-title":"Elife"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.gim.2022.04.005","article-title":"High-affinity Fc\u03b3RIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19","volume":"24","author":"Vietzen","year":"2022","journal-title":"Genet. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/imcb.12324","article-title":"Antibody-mediated complement activation in pathology and protection","volume":"98","author":"Goldberg","year":"2020","journal-title":"Immunol. Cell. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/vir.0.81808-0","article-title":"Porcine reproductive and respiratory syndrome virus-infected alveolar macrophages contain no detectable levels of viral proteins in their plasma membrane and are protected against antibody-dependent, complement-mediated cell lysis","volume":"87","author":"Costers","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1073\/pnas.1800177115","article-title":"HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions","volume":"115","author":"Nelson","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1073\/pnas.1800224115","article-title":"Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies","volume":"115","author":"Baraniak","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/7\/1442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:01:29Z","timestamp":1760126489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/7\/1442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":100,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["v15071442"],"URL":"https:\/\/doi.org\/10.3390\/v15071442","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]}}}