{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:19:07Z","timestamp":1760149147235,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad de Guadalajara"},{"name":"Centro Universitario de Ciencias de la Salud (CUCS)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human adenovirus 36 (HAdV-36) has been associated with obesity and changes in glucose and lipid metabolism. The virus has been reported to increase insulin sensitivity and paradoxically promote weight gain. Because of its effects on metabolism, infection with the virus could alter the response to several drugs used to treat type 2 diabetes (DM2), such as metformin. The aim of this study was to test whether HAdV-36 affects the response to metformin in a group of obese patients with DM2. Methods: In a prospective cohort study, 103 obese patients with newly diagnosed DM2 were divided into two groups based on their HAdV-36 seropositivity (+HAdV-36 and \u2212HAdV-36). Weight, glucose, cholesterol, triglycerides, body mass index, body fat percentage, and waist and hip circumference were measured and compared in both groups at baseline and after 45 days of metformin treatment. Results: Only glucose was significantly lower in the +HAdV-36 group at baseline, while all other variables were similar between the two study groups. After 45 days of follow-up, it was observed that the effect of metformin did not differ between the groups, but the variables improved significantly after treatment. Conclusions: In this study, we did not find that HAdV-36 had an effect on the response to metformin in obese patients with DM2.<\/jats:p>","DOI":"10.3390\/v15071514","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"1514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Human Adenovirus 36 on Response to Metformin Monotherapy in Obese Mexican Patients with Type 2 Diabetes: A Prospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Jos\u00e9 Carlos","family":"Tapia-Rivera","sequence":"first","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas para la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzm\u00e1n 49000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor Eduardo","family":"Mendoza-Jaramillo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas para la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzm\u00e1n 49000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Octavio","family":"Gonz\u00e1lez-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas para la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzm\u00e1n 49000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Ramirez-Flores","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas, Universidad de Colima, Colima 28040, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-5595","authenticated-orcid":false,"given":"Jos\u00e9 Alonso","family":"Aguilar-Velazquez","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-041X","authenticated-orcid":false,"given":"Andres","family":"L\u00f3pez-Quintero","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-1824","authenticated-orcid":false,"given":"Edsa\u00fal Emilio","family":"P\u00e9rez-Guerrero","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los \u00c1ngeles","family":"Vargas-Rodriguez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias de la Nutrici\u00f3n Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-0609","authenticated-orcid":false,"given":"Itzae Adonai","family":"Guti\u00e9rrez-Hurtado","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"},{"name":"Instituto de Nutrigen\u00e9tica y Nutrigen\u00f3mica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1029358","DOI":"10.3389\/fpubh.2022.1029358","article-title":"Public Knowledge and Awareness of Diabetes Mellitus, Its Risk Factors, Complications, and Prevention Methods among Adults in Poland\u2014A 2022 Nationwide Cross-Sectional Survey","volume":"10","author":"Pinkas","year":"2022","journal-title":"Front. 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