{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:57:17Z","timestamp":1792443437047,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>During 2000\u20132022, a total of 69 of Russia\u2019s 85 administrative regions reported 164,580 hemorrhagic fever with renal syndrome (HFRS) cases, with an annual average rate of 4.9 cases\/100,000 population (105 popul.). European Russia reported 162,045 (98.5%) cases in 53\/60 regions with 9.7 cases\/105 popul. Asian Russia reported 2535 (1.5%) cases in 16\/25 regions with 0.6 cases\/105 popul. In the same period, Russia reported 668 (0.4%) fatal HFRS cases, and 4030 (2.4%) cases among children under the age of 14 years. Most HFRS cases occurred during autumn and winter. The incidence among rural residents was 6.7 per 105 popul., higher than the urban 4.4 per 105 popul.; however, among HFRS patients, rural and urban residents account for 35% and 65%, respectively. Six hantaviruses, causing HFRS of different clinical severity, were recognized as pathogens: Hantaan (HTNV) and Amur (AMUV) of Orthohantavirus hantanense species, Seoul (SEOV) of Orthohantavirus seoulense species, Puumala (PUUV) of Orthohantavirus puumalaense species, and Kurkino (KURV) and Sochi (SOCV) of Orthohantavirus dobravaense species, with the principal hosts Apodemus agrarius coreae, Apodemus peninsulae, Rattus norvegicus, Myodes glareolus, Apodemus agrarius agrarius, and Sylvaemus ponticus, respectively. It was found that 97.7% of HFRS cases are caused by PUUV, therefore, this virus plays the main role in the HFRS morbidity structure in Russia.<\/jats:p>","DOI":"10.3390\/v15071537","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T01:43:22Z","timestamp":1689212602000},"page":"1537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cases of Hemorrhagic Fever with Renal Syndrome in Russia during 2000\u20132022"],"prefix":"10.3390","volume":"15","author":[{"given":"Evgeniy","family":"Tkachenko","sequence":"first","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Kurashova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Balkina","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-7136","authenticated-orcid":false,"given":"Alexander","family":"Ivanov","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Egorova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Leonovich","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Popova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostislav","family":"Teodorovich","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Belyakova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"Department of Internal Disease Propaedeutics, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Trankvilevsky","sequence":"additional","affiliation":[{"name":"Federal Center of Hygiene and Epidemiology, 117105 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Blinova","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, Central Research Institute of Epidemiology, 111123 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydar","family":"Ishmukhametov","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"},{"name":"Department of Internal Disease Propaedeutics, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Dzagurova","sequence":"additional","affiliation":[{"name":"FSASI \u201cChumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences\u201d (Institute of Poliomyelitis), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"ref_1","unstructured":"Targanskaia, V.A. (1935). Clinical Course of Acute Nephritis, Far Eastern Medical Institute. (In Russian)."},{"key":"ref_2","first-page":"7","article-title":"Clinical course of the so-called hemorrhagic nephroso-nephritis","volume":"19","author":"Churilov","year":"1941","journal-title":"Klin. Meditsina"},{"key":"ref_3","unstructured":"Terskikh, V.I. (1936). Dimitrov Leptospirosis, Dissertation Medical Institute. 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