{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:00:30Z","timestamp":1791324030606,"version":"4.3.1"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020","award":["793,090"],"award-info":[{"award-number":["793,090"]}]},{"name":"European Union\u2019s Horizon 2020","award":["SEV-2015-0533"],"award-info":[{"award-number":["SEV-2015-0533"]}]},{"name":"European Union\u2019s Horizon 2020","award":["CEX2019-000902-S"],"award-info":[{"award-number":["CEX2019-000902-S"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/","award":["793,090"],"award-info":[{"award-number":["793,090"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/","award":["SEV-2015-0533"],"award-info":[{"award-number":["SEV-2015-0533"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/","award":["CEX2019-000902-S"],"award-info":[{"award-number":["CEX2019-000902-S"]}]},{"name":"\u201cERDF A way of doing Europe\u201d","award":["793,090"],"award-info":[{"award-number":["793,090"]}]},{"name":"\u201cERDF A way of doing Europe\u201d","award":["SEV-2015-0533"],"award-info":[{"award-number":["SEV-2015-0533"]}]},{"name":"\u201cERDF A way of doing Europe\u201d","award":["CEX2019-000902-S"],"award-info":[{"award-number":["CEX2019-000902-S"]}]},{"DOI":"10.13039\/501100002809","name":"CERCA Program, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["793,090"],"award-info":[{"award-number":["793,090"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"CERCA Program, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SEV-2015-0533"],"award-info":[{"award-number":["SEV-2015-0533"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"CERCA Program, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["CEX2019-000902-S"],"award-info":[{"award-number":["CEX2019-000902-S"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Resistance to cucumber mosaic virus (CMV) strain LS in melon is controlled by the gene cmv1, which restricts phloem entry. In nature, CMV is commonly found in mixed infections, particularly with potyviruses, where a synergistic effect is frequently produced. We have explored the possibility that this synergism could help CMV-LS to overcome cmv1-mediated resistance. We demonstrate that during mixed infection with a potyvirus, CMV-LS is able to overcome cmv1-controlled resistance and develop a systemic infection and that this ability does not depend on an increased accumulation of CMV-LS in mechanically inoculated cotyledons. Likewise, during a mixed infection initiated by aphids, the natural vector of both cucumoviruses and potyviruses that can very efficiently inoculate plants with a low number of virions, CMV-LS also overcomes cmv1-controlled resistance. This indicates that in the presence of a potyvirus, even a very low amount of inoculum, can be sufficient to surpass the resistance and initiate the infection. These results indicate that there is an important risk for this resistance to be broken in nature as a consequence of mixed infections, and therefore, its deployment in elite cultivars would not be enough to ensure a long-lasting resistance.<\/jats:p>","DOI":"10.3390\/v15091792","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:09:53Z","timestamp":1692871793000},"page":"1792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["cmv1-Mediated Resistance to CMV in Melon Can Be Overcome by Mixed Infections with Potyviruses"],"prefix":"10.3390","volume":"15","author":[{"given":"Andrea","family":"Giordano","sequence":"first","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Edifici CRAG, Campus UAB, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-7537","authenticated-orcid":false,"given":"Inmaculada","family":"Ferriol","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Edifici CRAG, Campus UAB, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3176-9651","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"L\u00f3pez-Moya","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Edifici CRAG, Campus UAB, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-3847","authenticated-orcid":false,"given":"Ana Montserrat","family":"Mart\u00edn-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB, Edifici CRAG, Campus UAB, Bellaterra, 08193 Barcelona, Spain"},{"name":"Institut de Recerca i Tecnologia Agroaliment\u00e0ries (IRTA), Edifici CRAG, Campus UAB, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tree.2004.07.021","article-title":"Emerging infectious diseases of plants: Pathogen pollution, climate change and agrotechnology drivers","volume":"19","author":"Anderson","year":"2004","journal-title":"Trends Ecol. 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