{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:31:11Z","timestamp":1769635871279,"version":"3.49.0"},"reference-count":40,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Pernambuco Science and Technology Support Foundation (FACEPE)","doi-asserted-by":"publisher","award":["APQ-0560-2.12\/19"],"award-info":[{"award-number":["APQ-0560-2.12\/19"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Pernambuco Science and Technology Support Foundation (FACEPE)","doi-asserted-by":"publisher","award":["441030\/2020-3"],"award-info":[{"award-number":["441030\/2020-3"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Mayaro virus (MAYV), the etiologic agent of Mayaro fever, leads patients to severe myalgia and arthralgia, which can have a major impact on public health in all the countries where the virus circulates. The emergence and dissemination of new viruses have led the scientific community to develop new in vivo models that can help in the fight against new diseases. So far, mice have been the most used animal model in studies with MAYV and have proved to be an adequate model for recapitulating several aspects of the disease observed in humans. Mice are widely used in in vivo research and, therefore, are well known in the scientific community, which has allowed for different strains to be investigated in the study of MAYV. In this review, we summarize the main studies with MAYV using mice as an experimental model and discuss how they can contribute to the advancement of the understanding of its pathogenesis and the development of new drugs and vaccines.<\/jats:p>","DOI":"10.3390\/v15091803","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:33:09Z","timestamp":1692952389000},"page":"1803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mouse Models of Mayaro Virus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-6433","authenticated-orcid":false,"given":"Rafael Borges","family":"Rosa","sequence":"first","affiliation":[{"name":"Department of Virology and Experimental Therapy (LAVITE), Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Brazil"},{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia (REBIR-UFU), Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilene Ferreira","family":"de Castro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Uberlandia, Uberlandia 38400-902, Brazil"},{"name":"Dental Hospital, Oral Pathology Laboratory, University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"de Oliveira Santos","sequence":"additional","affiliation":[{"name":"Dental Hospital, Oral Pathology Laboratory, University of Uberlandia, Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Vieira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Rodents Animal Facilities Complex, Federal University of Uberlandia (REBIR-UFU), Uberlandia 38400-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-5699","authenticated-orcid":false,"given":"Lindomar Jos\u00e9","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Virology and Experimental Therapy (LAVITE), Aggeu Magalh\u00e3es Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3201\/eid1511.090461","article-title":"Mayaro fever virus, Brazilian amazon","volume":"15","author":"Azevedo","year":"2009","journal-title":"Emerg. 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