{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:18:36Z","timestamp":1790183916956,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal University of Par\u00e1 (UFPA)"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Coinfection of HPgV-1 with hepatitis C virus (HCV) is common due to shared modes of transmission, with a prevalence of HPgV-1 viremia of approximately 20% among individuals with chronic HCV infection. The aim of the present study was to estimate the prevalence of HPgV-1 RNA and circulating genotypes in patients with hepatitis C from a health service located in the city of Bel\u00e9m, in the state of Par\u00e1, Northern Brazil. A total of 147 samples were included in the study from February to December 2019. Among the participants, 72.1% (106\/147) were monoinfected with HCV, with detectable HCV viral RNA, and 27.9% (41\/147) were coinfected with HCV\/HPgV-1. The most frequently found genotypes were HPgV-1 genotypes 1 and 2 (36.6% and 63.4%), respectively. While for HCV there was a predominance of genotypes 1 and 3 (58.5% and 41.5%). No significant differences were found when comparing any risk, sociodemographic, or clinical factors between groups. Also, there was no statistically significant difference when relating the viral genotypes of both agents. This study indicated that the prevalence of infection by HPgV-1 is high in HCV carriers in Bel\u00e9m, Par\u00e1, and probably does not change the clinical course of HCV infection, however, further studies are still needed.<\/jats:p>","DOI":"10.3390\/v15091892","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:56:36Z","timestamp":1694080596000},"page":"1892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis C and Human Pegivirus Coinfection in Patients with Chronic Hepatitis C from the Brazilian Amazon Region: Prevalence, Genotypes and Clinical Data"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-1596","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Nunes","sequence":"first","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelen","family":"da Cruz Coelho","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseane","family":"da Silva","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regiane","family":"Sampaio","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Frade","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagib","family":"Ponteira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Hospital Ophir Loyola, Bel\u00e9m 66063-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Seabra","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Hospital Ophir Loyola, Bel\u00e9m 66063-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-4246","authenticated-orcid":false,"given":"Debora","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Hospital Ophir Loyola, Bel\u00e9m 66063-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel","family":"Burbano","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Hospital Ophir Loyola, Bel\u00e9m 66063-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-5164","authenticated-orcid":false,"given":"Luisa","family":"Martins","sequence":"additional","affiliation":[{"name":"N\u00facleo de Medicina Tropical, Laborat\u00f3rio de Patologia Cl\u00ednica das Doen\u00e7as Tropicais, Universidade Federal do Par\u00e1, Bel\u00e9m 66055-240, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tracli.2019.06.005","article-title":"Human Pegivirus-1 (Hpgv-1) Rna Prevalence and Genotypes in Volunteer Blood Donors from the Brazilian Amazon","volume":"26","author":"Slavova","year":"2019","journal-title":"Transfus. 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