{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:57:41Z","timestamp":1787234261566,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maternal and Child Health Association (Boshi-kenkou-kyoukai)","award":["R01-10"],"award-info":[{"award-number":["R01-10"]}]},{"name":"Maternal and Child Health Association (Boshi-kenkou-kyoukai)","award":["JP21wm0125006"],"award-info":[{"award-number":["JP21wm0125006"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["R01-10"],"award-info":[{"award-number":["R01-10"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development (AMED)","doi-asserted-by":"publisher","award":["JP21wm0125006"],"award-info":[{"award-number":["JP21wm0125006"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>We assessed the development, sensory status, and brain structure of children with congenital Zika virus (ZIKV) infection (CZI) at two years and preschool age. CZI was defined as either ZIKV RNA detection or positive ZIKV IgM and neutralization test in the cord or neonatal blood. Twelve children with CZI born in 2017\u20132018 in Vietnam, including one with Down syndrome, were assessed at 23\u201325.5 months of age, using Ages and Stages Questionnaire (ASQ-3), ASQ:Social-Emotional (ASQ:SE-2), Modified Checklist for Autism in Toddlers, automated auditory brainstem response (AABR), and Spot Vision Screener (SVS). They underwent brain CT and MRI. They had detailed ophthalmological examinations, ASQ-3, and ASQ:SE-2 at 51\u201362 months of age. None had birthweight or head circumference z-score &lt; \u22123 except for the one with Down syndrome. All tests passed AABR (n = 10). No ophthalmological problems were detected by SVS (n = 10) and detailed examinations (n = 6), except for a girl\u2019s astigmatism. Communication and problem-solving domains in a boy at 24 months, gross-motor area in a boy, and gross-motor and fine-motor areas in another boy at 59\u201361 months were in the referral zone. Brain CT (n = 8) and MRI (n = 6) revealed no abnormalities in the cerebrum, cerebellum, or brainstem other than cerebellar hypoplasia with Down syndrome. The CZI children were almost age-appropriately developed with no brain or eye abnormalities. Careful and longer follow-up is necessary for children with CZI.<\/jats:p>","DOI":"10.3390\/v15091928","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:36:45Z","timestamp":1694932605000},"page":"1928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Birth Cohort Follow-Up Study on Congenital Zika Virus Infection in Vietnam"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-9344","authenticated-orcid":false,"given":"Michiko","family":"Toizumi","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong Nguyen","family":"Vu","sequence":"additional","affiliation":[{"name":"Khanh Hoa Health Service, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Thi","family":"Huynh","sequence":"additional","affiliation":[{"name":"Khanh Hoa Health Service, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9584-4323","authenticated-orcid":false,"given":"Masafumi","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagasaki University Hospital, Nagasaki 852-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vy Thao","family":"Tran","sequence":"additional","affiliation":[{"name":"Khanh Hoa General Hospital, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Minh","family":"Vo","sequence":"additional","affiliation":[{"name":"Khanh Hoa General Hospital, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Anh Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-6307","authenticated-orcid":false,"given":"Mya Myat","family":"Ngwe Tun","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"},{"name":"Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo 693-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Xuan","family":"Bui","sequence":"additional","affiliation":[{"name":"Khanh Hoa Health Service, Nha Trang 650000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Anh","family":"Dang","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7448-8115","authenticated-orcid":false,"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-3248","authenticated-orcid":false,"given":"Lay-Myint","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Masmejan, S., Musso, D., Vouga, M., Pomar, L., Dashraath, P., Stojanov, M., Panchaud, A., and Baud, D. 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