{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:16:21Z","timestamp":1792790181372,"version":"4.5.0"},"reference-count":185,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund (FWF)","doi-asserted-by":"publisher","award":["J-4608"],"award-info":[{"award-number":["J-4608"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pfizer Inc.","award":["J-4608"],"award-info":[{"award-number":["J-4608"]}]},{"name":"International Trachoma Initiative","award":["J-4608"],"award-info":[{"award-number":["J-4608"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The global incidence of sexually transmitted infections (STIs) remains high, with the World Health Organization (WHO) estimating that over 1 million people acquire STIs daily. STIs can lead to infertility, pregnancy complications, and cancers. Co-infections with multiple pathogens are prevalent among individuals with an STI and can lead to heightened infectivity and more severe clinical manifestations. Chlamydia trachomatis (CT) is the most reported bacterial STI worldwide in both men and women, and several studies have demonstrated co-infection of CT with viral and other bacterial STIs. CT is a gram-negative bacterium with a unique biphasic developmental cycle including infectious extracellular elementary bodies (EBs) and metabolically active intracellular reticulate bodies (RBs). The intracellular form of this organism, RBs, has evolved mechanisms to persist for long periods within host epithelial cells in a viable but non-cultivable state. The co-infections of CT with the most frequently reported sexually transmitted viruses: human immunodeficiency virus (HIV), human papillomavirus (HPV), and herpes simplex virus (HSV) have been investigated through in vitro and in vivo studies. These research studies have made significant strides in unraveling the intricate interactions between CT, these viral STIs, and their eukaryotic host. In this review, we present an overview of the epidemiology of these co-infections, while specifically delineating the underlying mechanisms by which CT influences the transmission and infection dynamics of HIV and HSV. Furthermore, we explore the intricate relationship between CT and HPV infection, with a particular emphasis on the heightened risk of cervical cancer. By consolidating the current body of knowledge, we provide valuable insights into the complex dynamics and implications of co-infection involving CT and sexually transmitted viruses.<\/jats:p>","DOI":"10.3390\/v15091954","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T23:11:52Z","timestamp":1695165112000},"page":"1954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["When Bacteria and Viruses Collide: A Tale of Chlamydia trachomatis and Sexually Transmitted Viruses"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-6572","authenticated-orcid":false,"given":"Ehsan","family":"Ghasemian","sequence":"first","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1432-8109","authenticated-orcid":false,"given":"Emma","family":"Harding-Esch","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mabey","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5828-6318","authenticated-orcid":false,"given":"Martin J.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s41564-022-01177-x","article-title":"Sexually transmitted infections and female reproductive health","volume":"7","author":"Muzny","year":"2022","journal-title":"Nat. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.1016\/S2666-5247(21)00171-3","article-title":"WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017\u201318: A retrospective observational study","volume":"2","author":"Unemo","year":"2021","journal-title":"Lancet Microbe"},{"key":"ref_3","unstructured":"(CDC) Centers for Disease Control and Prevention (2022, March 16). Incidence, Prevalence, and Cost of Sexually Transmitted Infections in the United States, Available online: https:\/\/www.cdc.gov\/nchhstp\/newsroom\/fact-sheets\/std\/STI-Incidence-Prevalence-Cost-Factsheet.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0253-7184.74978","article-title":"Characterization of patients with multiple sexually transmitted infections: A hospital-based survey","volume":"31","author":"Choudhry","year":"2010","journal-title":"Indian J. Sex. Transm. Dis. AIDS"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/2325957415614644","article-title":"Coinfection of Sexually Transmitted Infections among HIV-Positive Individuals: Cross-Sectional Results of a Community-Based Positive Living with HIV (POLH) Study in Nepal","volume":"16","author":"Poudel","year":"2015","journal-title":"J. Int. Assoc. Provid. AIDS Care (JIAPAC)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1258\/0956462961918086","article-title":"Characterizing patients with multiple sexually acquired infections: A multivariate analysis","volume":"7","author":"Pakianathan","year":"1996","journal-title":"Int. J. STD AIDS"},{"key":"ref_7","first-page":"63","article-title":"High prevalence of coinfection of azithromycin-resistant Mycoplasma genitalium with other STIs: A prospective observational study of London-based symptomatic and STI-contact clinic attendees","volume":"97","author":"Furegato","year":"2020","journal-title":"Sex. Transm. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e24682","DOI":"10.1002\/jcla.24682","article-title":"Coinfections with multiple sexually transmitted pathogens in Republic of Korea, 2018","volume":"36","author":"Lee","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/sti.2010.047514","article-title":"Prevalence of sexually transmitted co-infections in people living with HIV\/AIDS: Systematic review with implications for using HIV treatments for prevention","volume":"87","author":"Kalichman","year":"2011","journal-title":"Sex. Transm. Infect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/OLQ.0b013e3181cfcb34","article-title":"STD Coinfections in The Netherlands: Specific Sexual Networks at Highest Risk","volume":"37","author":"Koedijk","year":"2010","journal-title":"Sex. Transm. Dis."},{"key":"ref_11","first-page":"40","article-title":"Sexual behaviour and sexually transmitted infections in sexually transmitted infection clinic attendees in the Netherlands, 2007\u20132011","volume":"25","author":"Warning","year":"2013","journal-title":"Int. J. STD AIDS"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"842644","DOI":"10.3389\/fpubh.2022.842644","article-title":"Patterns of Sexually Transmitted Co-infections and Associated Factors among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China","volume":"10","author":"Ye","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"G\u00f3es, S.d.S., Fonseca, R.R.d.S., Avelino, M.E.d.S., Lima, S.S., de Lima, M.S.G.A., Laurentino, R.V., Queiroz, M.A.F., Freitas, F.B., Vallinoto, A.C.R., and Ishak, R. (2022). Exposure to Chlamydia trachomatis Infection in Individuals Who Are Newly Diagnosed with HIV and Antiretroviral-Na\u00efve from Bel\u00e9m, Northern Brazil. Vaccines, 10.","DOI":"10.3390\/vaccines10101719"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e027245","DOI":"10.1136\/bmjopen-2018-027245","article-title":"Sexually transmitted infections in young people and factors associated with HIV coinfection: An observational study in a large city","volume":"9","author":"Arando","year":"2019","journal-title":"BMJ Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13027-017-0140-y","article-title":"Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland","volume":"12","author":"Ginindza","year":"2017","journal-title":"Infect. Agents Cancer"},{"key":"ref_16","first-page":"358402","article-title":"Sexually Transmitted Infections in Women Participating in a Biomedical Intervention Trial in Durban: Prevalence, Coinfections, and Risk Factors","volume":"2013","author":"Abbai","year":"2013","journal-title":"J. Sex. Transm. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nguyen, P.T.T., Pham, H.V., Van, D.H., Van Pham, L., Nguyen, H.T., and Van Nguyen, H. (2022). Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection. BMC Infect. Dis., 22.","DOI":"10.1186\/s12879-022-07595-w"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41467-022-28569-1","article-title":"Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming","volume":"13","author":"Koster","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1462-5822.2005.00608.x","article-title":"Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells","volume":"8","author":"Deka","year":"2006","journal-title":"Cell. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cornelisse, V.J., Sherman, C.J., Hocking, J.S., Williams, H., Zhang, L., Chen, M.Y., Bradshaw, C.S., Bellhouse, C., Fairley, C.K., and Chow, E.P.F. (2017). Concordance of chlamydia infections of the rectum and urethra in same-sex male partnerships: A cross-sectional analysis. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-016-2141-7"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/sextrans-2018-053823","article-title":"Mycoplasma genitalium incidence, persistence, concordance between partners and progression: Systematic review and meta-analysis","volume":"95","author":"Cina","year":"2019","journal-title":"Sex. Transm. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/01.olq.0000161089.53411.cb","article-title":"The Prevalence of Chlamydia, Gonorrhea, and Trichomonas in Sexual Partnerships: Implications for Partner Notification and Treatment","volume":"32","author":"Khan","year":"2005","journal-title":"Sex. Transm. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/OLQ.0000000000000525","article-title":"Genotype-Specific Concordance of Chlamydia trachomatis Genital Infection Within Heterosexual Partnerships","volume":"43","author":"Schillinger","year":"2016","journal-title":"Sex. Transm. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1086\/509934","article-title":"Trichomonas vaginalis Infection: The Most Prevalent Nonviral Sexually Transmitted Infection Receives the Least Public Health Attention","volume":"44","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.15698\/mic2016.09.525","article-title":"Chlamydia trachomatis Genital Infections","volume":"3","author":"Ferone","year":"2016","journal-title":"Microb. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rodrigues, R., Sousa, C., and Vale, N. (2022). Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities. Diagnostics, 12.","DOI":"10.3390\/diagnostics12081795"},{"key":"ref_27","unstructured":"(WHO) World Health Organization (2022). Sexually Transmitted Infections (STIs), WHO. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sexually-transmitted-infections-(stis)."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"a010256","DOI":"10.1101\/cshperspect.a010256","article-title":"Chlamydial Intracellular Survival Strategies","volume":"3","author":"Bastidas","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1086\/652394","article-title":"Chlamydia trachomatis Persistence In Vitro: An Overview","volume":"201","author":"Wyrick","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fcimb.2017.00253","article-title":"Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and \u03b1-SMA\u2014Implications for Epithelial-Mesenchymal Transition","volume":"7","author":"Stein","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1038\/s41598-018-23887-1","article-title":"Detection of Chlamydiaceae and Chlamydia-like organisms on the ocular surface of children and adults from a trachoma-endemic region","volume":"8","author":"Ghasemian","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1086\/652402","article-title":"Duration of Untreated, Uncomplicated Chlamydia trachomatis Genital Infection and Factors Associated with Chlamydia Resolution: A Review of Human Studies","volume":"201","author":"Geisler","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Champredon, D., E Bellan, S., Delva, W., Hunt, S., Shi, C.-F., Smieja, M., and Dushoff, J. (2015). The effect of sexually transmitted co-infections on HIV viral load amongst individuals on antiretroviral therapy: A systematic review and meta-analysis. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0961-5"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1590\/0074-02760150330","article-title":"Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples","volume":"111","author":"Wohlmeister","year":"2016","journal-title":"Mem\u00f3rias Do Inst. Oswaldo Cruz"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00404-013-3122-3","article-title":"Chlamydia trachomatis infection: Implications for HPV status and cervical cancer","volume":"289","author":"Silva","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1099\/jmm.0.000245","article-title":"HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy","volume":"65","author":"Seraceni","year":"2016","journal-title":"J. Med. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/157016212800618093","article-title":"Potential mechanisms for increased HIV-1 transmission across the endocervical epithelium during C. trachomatis infection","volume":"10","author":"Schust","year":"2012","journal-title":"Curr. HIV Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Buckner, L.R., Amedee, A.M., Albritton, H.L., Kozlowski, P.A., Lacour, N., McGowin, C.L., Schust, D.J., and Quayle, A.J. (2016). Chlamydia trachomatis Infection of Endocervical Epithelial Cells Enhances Early HIV Transmission Events. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146663"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1099\/mic.0.2007\/015164-0","article-title":"The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells","volume":"154","author":"Sun","year":"2008","journal-title":"Microbiology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1128\/IAI.70.5.2605-2613.2002","article-title":"Chlamydia trachomatis Disrupts N-Cadherin-Dependent Cell-Cell Junctions and Sequesters \u03b2-Catenin in Human Cervical Epithelial Cells","volume":"70","author":"Prozialeck","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_42","first-page":"12","article-title":"High seroprevalence of Chlamydia trachomatis in newly diagnosed human immunodeficiency virus patients in georgia","volume":"189","author":"Chkhartishvili","year":"2010","journal-title":"Georgian Med. News"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Mafokwane, T.M., and Samie, A. (2016). Prevalence of chlamydia among HIV positive and HIV negative patients in the Vhembe District as detected by real time PCR from urine samples Microbiology. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-1887-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"960769","DOI":"10.1155\/2013\/960769","article-title":"Chlamydia trachomatis Infection in HIV-Infected Women: Need for Screening by a Sensitive and Specific Test","volume":"2013","author":"Bhattar","year":"2013","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/1756-0500-6-301","article-title":"Sexually transmitted infections among patients with herpes simplex virus at King Abdulaziz University Hospital","volume":"6","author":"Fageeh","year":"2013","journal-title":"BMC Res. Notes"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9092565","DOI":"10.1155\/2019\/9092565","article-title":"HPV-Chlamydial Coinfection, Prevalence, and Association with Cervical Intraepithelial Lesions: A Pilot Study at Mbarara Regional Referral Hospital","volume":"2019","author":"Ssedyabane","year":"2019","journal-title":"J. Cancer Epidemiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.4269\/ajtmh.2012.12-0287","article-title":"Short Report: Molecular Detection of HPV and Chlamydia trachomatis Infections in Brazilian Women with Abnormal Cervical Cytology","volume":"87","author":"Teixeira","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1177\/0956462420947587","article-title":"Co-infection between genotypes of the human papillomavirus and Chlamydia trachomatis in Mexican women","volume":"31","year":"2020","journal-title":"Int. J. STD AIDS"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/infdis\/jiu240","article-title":"Increased Susceptibility to Vaginal Simian\/Human Immunodeficiency Virus Transmission in Pig-tailed Macaques Coinfected with Chlamydia trachomatis and Trichomonas vaginalis","volume":"210","author":"Henning","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lu, Y., Wu, Q., Central, S.Z., Li, H., Shanghai, W., Central, Z., Lingting, H., and Zhabei, J.S. Chlamydia Trachomatis Enhances HPV Persistence through Immune Modulation. Res. Square, 2022.","DOI":"10.21203\/rs.3.rs-1288504\/v1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1462-5822.2006.00823.x","article-title":"An early event in the herpes simplex virus type-2 replication cycle is sufficient to induce Chlamydia trachomatis persistence","volume":"9","author":"Deka","year":"2007","journal-title":"Cell. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Prusty, B.K., B\u00f6hme, L., Bergmann, B., Siegl, C., Krause, E., Mehlitz, A., and Rudel, T. (2012). Imbalanced Oxidative Stress Causes Chlamydial Persistence during Non-Productive Human Herpes Virus Co-Infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047427"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Prusty, B.K., Siegl, C., Hauck, P., Hain, J., Korhonen, S.J., Hiltunen-Back, E., Puolakkainen, M., and Rudel, T. (2013). Chlamydia trachomatis Infection Induces Replication of Latent HHV-6. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061400"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Di Pietro, M., Filardo, S., Simonelli, I., Pasqualetti, P., and Sessa, R. (2022). Cervicovaginal Microbiota Composition in Chlamydia trachomatis Infection: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179554"},{"key":"ref_55","first-page":"34","article-title":"HPV\/Chlamydia trachomatis co-infection: Metagenomic analysis of cervical microbiota in asymptomatic women","volume":"41","author":"Filardo","year":"2018","journal-title":"New Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/sextrans-2017-053346","article-title":"Vaginal microbiota composition and association with prevalent Chlamydia trachomatis infection: A cross-sectional study of young women attending a STI clinic in France","volume":"94","author":"Tamarelle","year":"2018","journal-title":"Sex. Transm. Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/AOG.0000000000001932","article-title":"Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases","volume":"129","author":"Lewis","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10096-020-04061-w","article-title":"Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis including relevant resistance-associated mutations in a single center in the Netherlands","volume":"40","author":"Nijhuis","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10096-022-04521-5","article-title":"The prevalence of Mycoplasma genitalium (MG) and Trichomonas vaginalis (TV) at testing centers in Belgium, Germany, Spain, and the UK using the cobas TV\/MG molecular assay","volume":"42","author":"Perry","year":"2023","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jongen, V.W., van der Loeff, M.F.S., Botha, M.H., Sudenga, S.L., Abrahamsen, M.E., and Giuliano, A.R. (2021). Incidence and risk factors of C. trachomatis and N. gonorrhoeae among young women from the Western Cape, South Africa: The EVRI study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0250871"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5534\/wjmh.190116","article-title":"Characterization and Trend of Co-Infection with Neisseria gonorrhoeae and Chlamydia trachomatis from the Korean National Infectious Diseases Surveillance Database","volume":"39","author":"Seo","year":"2021","journal-title":"World J. Men\u2019s Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-022-00359-5","article-title":"Trachoma","volume":"8","author":"Solomon","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/cid\/ciz429","article-title":"Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study among Primary Care Patients","volume":"69","author":"Heijer","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/QCO.0000000000000519","article-title":"Lymphoganuloma venereum in the Western world, 15 years after its re-emergence","volume":"32","year":"2019","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e00203-17","DOI":"10.1128\/CVI.00203-17","article-title":"Chlamydia trachomatis: The Persistent Pathogen","volume":"24","author":"Witkin","year":"2017","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"Elwell","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1128\/IAI.70.7.3793-3803.2002","article-title":"Chlamydia trachomatis Induces Remodeling of the Actin Cytoskeleton during Attachment and Entry into HeLa Cells","volume":"70","author":"Carabeo","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Moore, E.R., and Ouellette, S.P. (2014). Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: An expanded role for Inc proteins. Front. Cell. Infect. Microbiol., 4.","DOI":"10.3389\/fcimb.2014.00157"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The chlamydial developmental cycle","volume":"29","author":"AbdelRahman","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.vaccine.2021.03.043","article-title":"Chlamydia trachomatis: Cell biology, immunology and vaccination","volume":"39","author":"Murray","year":"2021","journal-title":"Vaccine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.micres.2005.04.004","article-title":"Chlamydia trachomatis persistence: An update","volume":"161","author":"Mpiga","year":"2006","journal-title":"Microbiol. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2003.08.005","article-title":"Differential expression of three Chlamydia trachomatis hsp60-encoding genes in active vs. persistent infections","volume":"36","author":"Schumacher","year":"2004","journal-title":"Microb. Pathog."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e00844-16","DOI":"10.1128\/JB.00844-16","article-title":"Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins","volume":"199","author":"Illingworth","year":"2017","journal-title":"J. Bacteriol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri1551","article-title":"Immunology of Chlamydia infection: Implications for a Chlamydia trachomatis vaccine","volume":"5","author":"Brunham","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3389\/fimmu.2014.00534","article-title":"The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword","volume":"5","author":"Redgrove","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Chen, A.L., Johnson, K.A., Lee, J.K., S\u00fctterlin, C., and Tan, M. (2012). CPAF: A Chlamydial Protease in Search of an Authentic Substrate. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002842"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Prusty, B.K., Chowdhury, S.R., Gulve, N., and Rudel, T. (2018). Peptidase Inhibitor 15 (PI15) Regulates Chlamydial CPAF Activity. Front. Cell. Infect. Microbiol., 8.","DOI":"10.3389\/fcimb.2018.00183"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/2049-632X.12213","article-title":"The Chlamydia protease CPAF: Caution, Precautions and Function","volume":"72","author":"Tan","year":"2014","journal-title":"Pathog. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/2049-632X.12179","article-title":"Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches","volume":"71","author":"Snavely","year":"2014","journal-title":"Pathog. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e01427-16","DOI":"10.1128\/mBio.01427-16","article-title":"Chlamydial Protease-Like Activity Factor and Type III Secreted Effectors Cooperate in Inhibition of p65 Nuclear Translocation","volume":"7","author":"Patton","year":"2016","journal-title":"mBio"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"18269","DOI":"10.1038\/s41598-020-75129-y","article-title":"Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease","volume":"10","author":"Schott","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1128\/IAI.66.9.4491-4495.1998","article-title":"Beta Interferon Is Produced by Chlamydia trachomatis -Infected Fibroblast-Like Synoviocytes and Inhibits Gamma Interferon-Induced HLA-DR Expression","volume":"66","author":"Rodel","year":"1998","journal-title":"Infect. Immun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8604958","DOI":"10.1155\/2019\/8604958","article-title":"Chlamydia and Its Many Ways of Escaping the Host Immune System","volume":"2019","author":"Wong","year":"2019","journal-title":"J. Pathog."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41564-018-0182-y","article-title":"Chlamydia trachomatis paralyses neutrophils to evade the host innate immune response","volume":"3","author":"Rajeeve","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"15035","DOI":"10.1038\/nrdp.2015.35","article-title":"HIV infection","volume":"1","author":"Deeks","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41576-021-00378-0","article-title":"HIV-1 and human genetic variation","volume":"22","author":"McLaren","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"ref_87","unstructured":"(WHO) World Health Organization (2023). HIV Data and Statistics, WHO. Available online: https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/strategic-information\/hiv-data-and-statistics."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1056\/NEJMra0706737","article-title":"The Challenge of HIV-1 Subtype Diversity","volume":"358","author":"Taylor","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"780922","DOI":"10.3389\/fimmu.2022.780922","article-title":"The Role of Innate Immunity in Natural Elite Controllers of HIV-1 Infection","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.virol.2017.12.012","article-title":"HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles","volume":"515","author":"Yasen","year":"2018","journal-title":"Virology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1067\/mai.2002.126226","article-title":"Molecular virology and immunology of HIV infection","volume":"110","author":"Chinen","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1038\/s41598-021-82066-x","article-title":"T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells","volume":"11","author":"Schiff","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"816515","DOI":"10.3389\/fimmu.2021.816515","article-title":"Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy","volume":"12","author":"Mohamed","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"a006866","DOI":"10.1101\/cshperspect.a006866","article-title":"HIV: Cell Binding and Entry","volume":"2","author":"Wilen","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/978-94-007-6552-8_16","article-title":"Entry of Enveloped Viruses into Host Cells: Membrane Fusion","volume":"68","author":"Melero","year":"2013","journal-title":"Subcell Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"960","DOI":"10.4103\/0971-5916.92643","article-title":"Genital mycoplasma & Chlamydia trachomatis infections in treatment na\u00efve HIV-1 infected adults","volume":"134","author":"Dhawan","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(89)90589-8","article-title":"Female to male transmission of human immunodeficiency virus type 1: Risk factors for seroconversion in men","volume":"334","author":"Cameron","year":"1989","journal-title":"Lancet"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/OLQ.0b013e3181812d15","article-title":"The Effect of Genital Tract Infections on HIV-1 Shedding in the Genital Tract: A Systematic Review and Meta-Analysis","volume":"35","author":"Johnson","year":"2008","journal-title":"Sex. Transm. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0253-7184.142405","article-title":"Co-infection of human immunodeficiency virus and sexually transmitted infections in circumcised and uncircumcised cases in India","volume":"35","author":"Sherwal","year":"2014","journal-title":"Indian J. Sex. Transm. Dis. AIDS"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0140-6736(95)91380-7","article-title":"Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: Randomised controlled trial","volume":"346","author":"Grosskurth","year":"1995","journal-title":"Lancet"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00007435-200005000-00001","article-title":"Effect of Coinfection With STDs and of STD Treatment on HIV Shedding in Genital-Tract Secretions: Systematic Review and Data Synthesis","volume":"27","author":"Rotchford","year":"2000","journal-title":"Sex. Transm. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1600-0897.2010.00942.x","article-title":"Interactions of HIV, Other Sexually Transmitted Diseases, and Genital Tract Inflammation Facilitating Local Pathogen Transmission and Acquisition","volume":"65","author":"Mayer","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1097\/00002030-199712000-00001","article-title":"The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, C\u00f4te d\u2019Ivoire","volume":"11","author":"Ghys","year":"1997","journal-title":"AIDS"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/OLQ.0000000000000423","article-title":"HIV Incidence Among Men Who Have Sex with Men after Diagnosis with Sexually Transmitted Infections","volume":"43","author":"Katz","year":"2016","journal-title":"Sex. Transm. Dis."},{"key":"ref_105","first-page":"537","article-title":"Rectal Gonorrhea and Chlamydia Reinfection Is Associated with Increased Risk of HIV Seroconversion","volume":"53","author":"Bernstein","year":"2010","journal-title":"Am. J. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/IPC.0b013e3181aba461","article-title":"The Bidirectional Interactions of Human Immunodeficiency Virus-1 and Sexually Transmitted Infections","volume":"17","author":"Naresh","year":"2009","journal-title":"Infect. Dis. Clin. Pract."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/cid\/cit437","article-title":"HIV Incidence among Men with and Those without Sexually Transmitted Rectal Infections: Estimates from Matching against an HIV Case Registry","volume":"57","author":"Pathela","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00002030-200101050-00015","article-title":"Treatment of cervicitis is associated with decreased cervical shedding of HIV-1","volume":"15","author":"McClelland","year":"2001","journal-title":"AIDS"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/sti.2004.010249","article-title":"The effects of urethritis on seminal plasma HIV-1 RNA loads in homosexual men not receiving antiretroviral therapy","volume":"81","author":"Sadiq","year":"2005","journal-title":"Sex. Transm. Infect."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrmicro794","article-title":"The role of sexually transmitted diseases in HIV transmission","volume":"2","author":"Galvin","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/00007435-200110000-00005","article-title":"A Systematic Review of the Epidemiologic Interactions between Classic Sexually Transmitted Diseases and HIV","volume":"28","author":"Cameron","year":"2001","journal-title":"Sex. Transm. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00002030-199902250-00004","article-title":"Increased interleukin-10 in the endocervical secretions of women with non-ulcerative sexually transmitted diseases: A mechanism for enhanced HIV-1 transmission?","volume":"13","author":"Cohen","year":"1999","journal-title":"AIDS"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1600-0897.2008.00639.x","article-title":"A Distinct Cellular Profile Is Seen in the Human Endocervix during Chlamydia trachomatis Infection","volume":"60","author":"Ficarra","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"McGowin, C.L., Popov, V.L., and Pyles, R.B. (2009). Intracellular Mycoplasma genitalium infection of human vaginal and cervical epithelial cells elicits distinct patterns of inflammatory cytokine secretion and provides a possible survival niche against macrophage-mediated killing. BMC Microbiol., 9.","DOI":"10.1186\/1471-2180-9-139"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1097\/QAD.0000000000001580","article-title":"Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation","volume":"31","author":"Vieira","year":"2017","journal-title":"AIDS"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/S0140-6736(97)02190-9","article-title":"Reduction of concentration of HIV-1 in semen after treatment of urethritis: Implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group","volume":"349","author":"Cohen","year":"1997","journal-title":"Lancet"},{"key":"ref_117","first-page":"16","article-title":"HIV-1\u2013Infected Peripheral Blood Mononuclear Cells Enhance Neutrophil Survival and HLA-DR Expression via Increased Production of GM-CSF: Implications for HIV-1 Infection","volume":"56","author":"Fu","year":"2011","journal-title":"Am. J. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.jid.2021.09.020","article-title":"Chlamydia trachomatis Stimulation Enhances HIV-1 Susceptibility through the Modulation of a Member of the Macrophage Inflammatory Proteins","volume":"142","author":"Dzakah","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fonc.2019.00355","article-title":"Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology","volume":"9","author":"Gheit","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"552028","DOI":"10.3389\/fpubh.2020.552028","article-title":"Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation","volume":"8","author":"Kombe","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"16086","DOI":"10.1038\/nrdp.2016.86","article-title":"Carcinogenic human papillomavirus infection","volume":"2","author":"Schiffman","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/MMBR.68.2.362-372.2004","article-title":"Pathogenesis of Human Papillomaviruses in Differentiating Epithelia","volume":"68","author":"Longworth","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3389\/fonc.2019.00682","article-title":"Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System","volume":"9","author":"Zhou","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ijc.31027","article-title":"Immune evasion mechanisms of human papillomavirus: An update","volume":"142","author":"Steinbach","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virusres.2016.11.023","article-title":"Evasion of host immune defenses by human papillomavirus","volume":"231","author":"Westrich","year":"2017","journal-title":"Virus Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The Biology and Life-Cycle of Human Papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13669-021-00319-y","article-title":"Association of Human Papillomavirus and Chlamydia trachomatis Coinfection with Cervical Intraepithelial Lesions and Cervical Cancer","volume":"11","author":"Kilic","year":"2022","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Chen, H., Luo, L., Wen, Y., He, B., Ling, H., Shui, J., He, P., Hou, X., Tang, S., and Li, Z. (2020). Chlamydia trachomatis and Human Papillomavirus Infection in Women from Southern Hunan Province in China: A Large Observational Study. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00827"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"753.e1","DOI":"10.1016\/j.ajog.2016.07.003","article-title":"Prevalence and factors associated with coinfection of human papillomavirus and Chlamydia trachomatis in adolescents and young women","volume":"215","author":"Nonato","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Verteramo, R., Pierangeli, A., Mancini, E., Calzolari, E., Bucci, M., Osborn, J., Nicosia, R., Chiarini, F., Antonelli, G., and Degener, A.M. (2009). Human Papillomaviruses and genital co-infections in gynaecological outpatients. BMC Infect. Dis., 9.","DOI":"10.1186\/1471-2334-9-16"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"19924","DOI":"10.1038\/s41598-021-99279-9","article-title":"Association between Human Papillomavirus and Chlamydia trachomatis genital infections in male partners of infertile couples","volume":"11","author":"Olivera","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Soto, E., Fern\u00e1ndez-Mart\u00ednez, E., Oros-Pantoja, R., Medel-Flores, O., Miranda-Covarrubias, J.C., and S\u00e1nchez-Monroy, V. (2021). Proinflammatory and Oxidative Stress States Induced by Human Papillomavirus and Chlamydia trachomatis Coinfection Affect Sperm Quality in Asymptomatic Infertile Men. Medicina, 57.","DOI":"10.3390\/medicina57090862"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00038-019-01261-w","article-title":"Association between human papillomavirus and chlamydia trachomatis infection risk in women: A systematic review and meta-analysis","volume":"64","author":"Naldini","year":"2019","journal-title":"Int. J. Public Health"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0732-8893(02)00403-0","article-title":"Cervicovaginal coinfections with human papillomavirus and chlamydia trachomatis","volume":"43","author":"Tamim","year":"2002","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Yang, D., Zhang, J., Cui, X., Ma, J., Wang, C., and Piao, H. (2022). Risk Factors Associated with Human Papillomavirus Infection, Cervical Cancer, and Precancerous Lesions in Large-Scale Population Screening. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.914516"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jinf.2012.10.024","article-title":"Risk factors for and prevention of human papillomaviruses (HPV), genital warts and cervical cancer","volume":"66","author":"Chelimo","year":"2013","journal-title":"J. Infect."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1469-0691.2008.02647.x","article-title":"Genital Chlamydia trachomatis infections","volume":"15","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/CMR.00035-15","article-title":"Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women","volume":"28","author":"Menon","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Huai, P., Li, F., Li, Z., Sun, L., Fu, X., Pan, Q., Yu, G., Chai, Z., Chu, T., and Mi, Z. (2018). Prevalence, risk factors, and medical costs of Chlamydia trachomatis infections in Shandong Province, China: A population-based, cross-sectional study. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3432-y"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/infdis\/jiy497","article-title":"The Burden of Human Papillomavirus and Chlamydia trachomatis Coinfection in Women: A Large Cohort Study in Inner Mongolia, China","volume":"219","author":"Ji","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/aje\/kwi262","article-title":"Association of Chlamydia trachomatis with Persistence of High-Risk Types of Human Papillomavirus in a Cohort of Female Adolescents","volume":"162","author":"Samoff","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Lugo, L.Z.A., Puga, M.A.M., Jacob, C.M.B., Padovani, C.T.J., Nocetti, M.C., Tupin\u00e1, M.S., Pina, A.F.S., de Freitas, J.N.M., Ferreira, A.M.T., and Fernandes, C.E.d.S. (2023). Cytokine profiling of samples positive for Chlamydia trachomatis and Human papillomavirus. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0279390"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.micinf.2009.01.004","article-title":"Immunological\u2019s host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor","volume":"11","author":"Simonetti","year":"2009","journal-title":"Microbes Infect."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ijc.10639","article-title":"A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma","volume":"101","author":"Wallin","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Scurtu, L.G., Jinga, V., and Simionescu, O. (2022). Fascinating Molecular and Immune Escape Mechanisms in the Treatment of STIs (Syphilis, Gonorrhea, Chlamydia, and Herpes Simplex). Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073550"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1158\/1055-9965.EPI-15-0420","article-title":"MMP-9\/RECK Imbalance: A Mechanism Associated with High-Grade Cervical Lesions and Genital Infection by Human Papillomavirus and Chlamydia trachomatis","volume":"24","author":"Discacciati","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.7150\/jca.58582","article-title":"Chlamydia Trachomatis Infection: Their potential implication in the Etiology of Cervical Cancer","volume":"12","author":"Yang","year":"2021","journal-title":"J. Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1128\/JVI.77.2.1551-1563.2003","article-title":"Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, Senescence, and Apoptosis in HeLa Cervical Carcinoma Cells","volume":"77","author":"DeFilippis","year":"2003","journal-title":"J. Virol."},{"key":"ref_149","first-page":"e21331","article-title":"The Role of Chlamydia Trachomatis in the Pathogenesis of Cervical Cancer","volume":"14","author":"Franchini","year":"2022","journal-title":"Cureus"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Wang, K., Mu\u00f1oz, K.J., Tan, M., and S\u00fctterlin, C. (2021). Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms. Cell. Microbiol., 23.","DOI":"10.1111\/cmi.13397"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Mirzayans, R., Andrais, B., and Murray, D. (2018). Roles of Polyploid\/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment. Cancers, 10.","DOI":"10.3390\/cancers10040118"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Knowlton, A.E., Fowler, L.J., Patel, R.K., Wallet, S.M., and Grieshaber, S.S. (2013). Chlamydia Induces Anchorage Independence in 3T3 Cells and Detrimental Cytological Defects in an Infection Model. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054022"},{"key":"ref_153","first-page":"533","article-title":"Association of Chlamydia trachomatis infection with human papillomavirus (HPV) & cervical intraepithelial neoplasia\u2014A pilot study","volume":"137","author":"Bhatla","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Mosmann, J.P., Zayas, S., Kiguen, A.X., Venezuela, R.F., Rosato, O., and Cuffini, C.G. (2021). Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06118-3"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1089\/aid.2011.0307","article-title":"Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru","volume":"28","author":"Quinn","year":"2012","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2217\/fvl.15.85","article-title":"Cell entry mechanisms of HSV: What we have learned in recent years","volume":"10","author":"Agelidis","year":"2015","journal-title":"Futur. Virol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaad.2007.06.027","article-title":"Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management","volume":"57","author":"Fatahzadeh","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_158","unstructured":"(WHO) World Health Organization (2023). Herpes Simplex Virus, WHO. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/herpes-simplex-virus."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S1473-3099(19)30470-0","article-title":"Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence: A population attributable fraction analysis using published epidemiological data","volume":"20","author":"Looker","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/flgastro-2012-100274","article-title":"Sexually transmitted infections manifesting as proctitis","volume":"4","author":"Lamb","year":"2012","journal-title":"Front. Gastroenterol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1128\/JVI.02110-06","article-title":"Herpes Simplex Virus Type 2 (HSV-2) Establishes Latent Infection in a Different Population of Ganglionic Neurons than HSV-1: Role of Latency-Associated Transcripts","volume":"81","author":"Margolis","year":"2007","journal-title":"J. Virol."},{"key":"ref_162","unstructured":"Retamal-D\u00edaz, A.R., Tognarelli, E., Kalergis, A.M., Bueno, S.M., and Gonz\u00e1lez, P.A. (2016). Herpesviridae, InTech."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3390\/v1030737","article-title":"Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus","volume":"1","author":"Melchjorsen","year":"2009","journal-title":"Viruses"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-065X.2011.01074.x","article-title":"Immune modulation during latent herpesvirus infection","volume":"245","author":"White","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00007435-198807000-00012","article-title":"Dual Infection of the Conjunctiva with Herpes Simplex Virus and Chlamydia trachomatis","volume":"15","author":"Mantell","year":"1988","journal-title":"Sex. Transm. Dis."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Mosmann, J.P., Talavera, A.D., Criscuolo, M.I., Venezuela, R.F., Kiguen, A.X., Panico, R., De Prato, R.F., De Blanc, S.A.L., R\u00e9, V., and Cuffini, C.G. (2019). Sexually transmitted infections in oral cavity lesions: Human papillomavirus, Chlamydia trachomatis, and Herpes simplex virus. J. Oral Microbiol., 11.","DOI":"10.1080\/20002297.2019.1632129"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"E166","DOI":"10.1111\/1469-0691.12105","article-title":"A retrospective study into the prevalence of herpes simplex virus 1&2 in female patients tested for Chlamydia trachomatis and\/or Neisseria gonorrhoeae using vaginal swabs","volume":"19","author":"Vahidnia","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Shaw, S.Y., Deering, K.N., Reza-Paul, S., Isac, S., Ramesh, B.M., Washington, R., Moses, S., and Blanchard, J.F. (2011). Prevalence of HIV and sexually transmitted infections among clients of female sex workers in Karnataka, India: A cross-sectional study. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-S6-S4"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00150443","article-title":"Seroprevalence of anti-Chlamydia trachomatis IgG in outpatients attending a sexually transmitted disease clinic in Italy","volume":"6","author":"Paroli","year":"1990","journal-title":"Eur. J. Epidemiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/sti.66.3.182","article-title":"Seroepidemiology of chlamydia in Costa Rica","volume":"66","author":"Vetter","year":"1990","journal-title":"Sex. Transm. Infect."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Slade, J., Hall, J.V., Kintner, J., and Schoborg, R.V. (2016). Chlamydial Pre-Infection Protects from Subsequent Herpes Simplex Virus-2 Challenge in a Murine Vaginal Super-Infection Model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146186"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/j.1471-0528.1981.tb01767.x","article-title":"Chlamydia trachomatis and herpes simplex virus IgA antibodies in cervical secretions of patients with cervical atypia","volume":"88","author":"Kalimo","year":"1981","journal-title":"BJOG: Int. J. Obstet. Gynaecol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00404-009-0998-z","article-title":"Seroprevalences of herpes simplex virus type 2 and Chlamydia trachomatis in Turkey","volume":"280","author":"Maral","year":"2009","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Rahman, S., Wathington, D., Waterboer, T., Pawlita, M., Villa, L.L., Lazcano-Ponce, E., Willhauck-Fleckenstein, M., Brenner, N., and Giuliano, A.R. (2021). Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18\u201370 years from three countries. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0253005"},{"key":"ref_175","first-page":"1","article-title":"The Seroprevalence and Co-Existence of Chlamydia Trachomatis and Herpes Simplex Virus Antibodies among Students in a Tertiary Institution","volume":"1","author":"Duru","year":"2014","journal-title":"Int. J. Med. Med. Sci."},{"key":"ref_176","first-page":"27","article-title":"Pap testing and direct immunofluorescence for Chlamydia trachomatis infection in pregnant women","volume":"131","author":"Kajaia","year":"2006","journal-title":"Georgian Med. News"},{"key":"ref_177","first-page":"263","article-title":"In vitro study of a double infection by herpes simplex virus type 2 and Chlamydia trachomatis","volume":"19","author":"Chiarini","year":"1996","journal-title":"New Microbiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1128\/jvi.60.1.37-42.1986","article-title":"Effect of interferon on replication of herpes simplex virus types 1 and 2 in human macrophages","volume":"60","author":"Straub","year":"1986","journal-title":"J. Virol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1086\/519693","article-title":"Polymorphisms in TLR2 Are Associated with Increased Viral Shedding and Lesional Rate in Patients with Genital Herpes Simplex Virus Type 2 Infection","volume":"196","author":"Bochud","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1099\/vir.0.030296-0","article-title":"Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells","volume":"92","author":"Yao","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1099\/mic.0.036566-0","article-title":"Interaction of herpes simplex virus type 2 (HSV-2) glycoprotein D with the host cell surface is sufficient to induce Chlamydia trachomatis persistence","volume":"156","author":"Vanover","year":"2010","journal-title":"Microbiology"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"e01842-17","DOI":"10.1128\/JVI.01842-17","article-title":"The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes","volume":"92","author":"Musarrat","year":"2018","journal-title":"J. Virol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fcimb.2014.00158","article-title":"Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development","volume":"4","author":"Hall","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1385\/MB:13:2:89","article-title":"Basic Problems of Serological Laboratory Diagnosis","volume":"13","author":"Fierz","year":"1999","journal-title":"Mol. Biotechnol."},{"key":"ref_185","unstructured":"Murray, P.R. (2015). Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infec-tious Diseases, Elsevier."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/9\/1954\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:54:04Z","timestamp":1760129644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/15\/9\/1954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":185,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["v15091954"],"URL":"https:\/\/doi.org\/10.3390\/v15091954","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]}}}