{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:16:37Z","timestamp":1791432997624,"version":"4.3.3"},"reference-count":141,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Sciences and Engineering Research Council of Canada","award":["90887-2010 RGPIN"],"award-info":[{"award-number":["90887-2010 RGPIN"]}]},{"name":"Natural Sciences and Engineering Research Council of Canada","award":["PJT-196-150"],"award-info":[{"award-number":["PJT-196-150"]}]},{"name":"Canadian Institutes of Health Research","award":["90887-2010 RGPIN"],"award-info":[{"award-number":["90887-2010 RGPIN"]}]},{"name":"Canadian Institutes of Health Research","award":["PJT-196-150"],"award-info":[{"award-number":["PJT-196-150"]}]},{"name":"Government of Saskatchewan","award":["90887-2010 RGPIN"],"award-info":[{"award-number":["90887-2010 RGPIN"]}]},{"name":"Government of Saskatchewan","award":["PJT-196-150"],"award-info":[{"award-number":["PJT-196-150"]}]},{"name":"Canada Foundation for Innovation","award":["90887-2010 RGPIN"],"award-info":[{"award-number":["90887-2010 RGPIN"]}]},{"name":"Canada Foundation for Innovation","award":["PJT-196-150"],"award-info":[{"award-number":["PJT-196-150"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Herpesviruses are enveloped and have an amorphous protein layer surrounding the capsid, which is termed the tegument. Tegument proteins perform critical functions throughout the viral life cycle. This review provides a comprehensive and comparative analysis of the roles of specific tegument proteins in capsid transport and virion morphogenesis of selected, well-studied prototypes of each of the three subfamilies of Herpesviridae i.e., human herpesvirus-1\/herpes simplex virus-1 (Alphaherpesvirinae), human herpesvirus-5\/cytomegalovirus (Betaherpesvirinae) and human herpesvirus -8\/Kaposi\u2019s sarcomavirus (Gammaherpesvirinae). Most of the current knowledge is based on alpha herpesviruses, in particular HSV-1. While some tegument proteins are released into the cytoplasm after virus entry, several tegument proteins remain associated with the capsid and are responsible for transport to and docking at the nucleus. After replication and capsid formation, the capsid is enveloped at the nuclear membrane, which is referred to as primary envelopment, followed by de-envelopment and release into the cytoplasm. This requires involvement of at least three tegument proteins. Subsequently, multiple interactions between tegument proteins and capsid proteins, other tegument proteins and glycoproteins are required for assembly of the virus particles and envelopment at the Golgi, with certain tegument proteins acting as the central hub for these interactions. Some redundancy in these interactions ensures appropriate morphogenesis.<\/jats:p>","DOI":"10.3390\/v15102058","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:17:26Z","timestamp":1696688246000},"page":"2058","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comprehensive Analysis of the Tegument Proteins Involved in Capsid Transport and Virion Morphogenesis of Alpha, Beta and Gamma Herpesviruses"],"prefix":"10.3390","volume":"15","author":[{"given":"Soumya","family":"Sucharita","sequence":"first","affiliation":[{"name":"Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada"},{"name":"Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshaya","family":"Krishnagopal","sequence":"additional","affiliation":[{"name":"Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada"},{"name":"Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"van Drunen Littel-van den Hurk","sequence":"additional","affiliation":[{"name":"Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada"},{"name":"Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00705-008-0278-4","article-title":"The order Herpesvirales","volume":"154","author":"Davison","year":"2009","journal-title":"Arch. 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