{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:20:47Z","timestamp":1790824847012,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>We highlighted in this current paper similar prolonged respiratory presentation with COVID-19 pneumonia in four severely immunocompromised patients currently being treated with anti-CD20 monoclonal antibodies (mAbs), such as ocrelizumab and rituximab, for multiple sclerosis or rheumatoid polyarthritis. Real-time reverse transcription-polymerase chain reaction on a nasopharyngeal swab specimen was negative in all patients. SARS-CoV-2 infection was confirmed from bronchoalveolar lavage fluid. A high titer of post-vaccine COVID-19 convalescent plasma was administered with complete recovery in all patients.<\/jats:p>","DOI":"10.3390\/v15112220","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:23:39Z","timestamp":1699356219000},"page":"2220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prolonged SARS-CoV-2 Infection in Patients Receiving Anti-CD20 Monoclonal Antibodies: A Diagnostic Challenged by Negative Nasopharyngeal RT-PCR and Successful Treatment with COVID-19 High-Titer Convalescent Plasma"],"prefix":"10.3390","volume":"15","author":[{"given":"L\u00e9a","family":"Da Silva","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-9889","authenticated-orcid":false,"given":"Timoth\u00e9e","family":"Klopfenstein","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-9359","authenticated-orcid":false,"given":"Vincent","family":"Gendrin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Clouet","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Toko","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-6405","authenticated-orcid":false,"given":"Quentin","family":"Richier","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Assistance Publique Hopitaux de Paris, Saint-Antoine Hospital, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Leriche","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Nord Franche-Comte Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Pneumologie Department, Nord Franche-Comte Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Queijo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Sreiri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Assistance Publique Hopitaux de Paris, Saint-Antoine Hospital, 75012 Paris, France"},{"name":"INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP), Sorbonne University, 75646 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-9806","authenticated-orcid":false,"given":"Souheil","family":"Zayet","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Nord Franche-Comt\u00e9 Hospital, 90400 Trevenans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ofab176","DOI":"10.1093\/ofid\/ofab176","article-title":"Prolonged SARS-CoV-2 Illness in a Patient Receiving Ocrelizumab for Multiple Sclerosis","volume":"8","author":"Gibson","year":"2021","journal-title":"Open Forum Infect. 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