{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:17:43Z","timestamp":1767212263191,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["L222074","2019JZZY011011"],"award-info":[{"award-number":["L222074","2019JZZY011011"]}]},{"name":"Key R&amp;D Program of Shandong Province","award":["L222074","2019JZZY011011"],"award-info":[{"award-number":["L222074","2019JZZY011011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Herpes zoster (HZ) is a disease caused by the reactivation of latent varicella-zoster virus (VZV). The subunit vaccine, Shingrix\u00ae, and live attenuated vaccine, Zostavax\u00ae, could be used as an HZ vaccine that prevents HZ from being developed due to the reactivation of latent VZV in the sensory ganglia due to aging, stress or immunosuppression. In this study, the recombinant adenoviruses rChAd63\/gE expressing glycoprotein E (gE) of VZV based on chimpanzee adenovirus serotype 63 (ChAd63) were constructed and investigated for the immunogenicity of different immune pathways in C57BL\/6 mice. The results showed similar CD4+ T and CD8+ T cell responses to Shingrix\u00ae were induced in mice vaccinated using rChAd63\/gE via different immune pathways. This study elucidates that recombinant adenoviruses expressing VZV gE could be appropriate for further development as a new HZ vaccine candidate via different immune pathways.<\/jats:p>","DOI":"10.3390\/v15122288","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:47:43Z","timestamp":1700642863000},"page":"2288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunogenicity in Mice Immunized with Recombinant Adenoviruses Expressing Varicella-Zoster Virus Envelope Glycoprotein E"],"prefix":"10.3390","volume":"15","author":[{"given":"Yanpeng","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiru","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawei","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigan","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-384X","authenticated-orcid":false,"given":"Jiemei","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglei","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhui","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6592-0540","authenticated-orcid":false,"given":"Jinsheng","family":"He","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S429","DOI":"10.1093\/infdis\/jiab387","article-title":"Herpes Zoster Vaccines","volume":"224","author":"Harbecke","year":"2021","journal-title":"J. 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