{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:49:00Z","timestamp":1789757340282,"version":"4.0.1"},"reference-count":90,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biosafety and Technology Major Program of Hubei Jiangxia Laboratory","award":["JXBS009"],"award-info":[{"award-number":["JXBS009"]}]},{"name":"Biosafety and Technology Major Program of Hubei Jiangxia Laboratory","award":["2023020201010089"],"award-info":[{"award-number":["2023020201010089"]}]},{"name":"Knowledge Innovation Program of Wuhan","award":["JXBS009"],"award-info":[{"award-number":["JXBS009"]}]},{"name":"Knowledge Innovation Program of Wuhan","award":["2023020201010089"],"award-info":[{"award-number":["2023020201010089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3\u2032 untranslated region (3\u2032 UTR), a result of the action of the host 5\u2032-3\u2032 exoribonuclease, Xrn1, when it encounters specific RNA structures known as Xrn1-resistant RNAs (xrRNAs) within the viral 3\u2032 UTR. Dengue viruses generate three to four distinct species of sfRNAs through the presence of two xrRNAs and two dumbbell structures (DBs). The tertiary structures of xrRNAs have been characterized to form a ringlike structure around the 5\u2032 end of the viral RNA, effectively inhibiting the activity of Xrn1. The most important role of DENV sfRNAs is to inhibit host antiviral responses by interacting with viral and host proteins, thereby influencing viral pathogenicity, replicative fitness, epidemiological fitness, and transmission. In this review, we aimed to summarize the biogenesis, structures, and functions of DENV sfRNAs, exploring their implications for viral interference.<\/jats:p>","DOI":"10.3390\/v15122306","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T06:51:28Z","timestamp":1700808688000},"page":"2306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Subgenomic Flaviviral RNAs of Dengue Viruses"],"prefix":"10.3390","volume":"15","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Hubei Jiangxia Laboratory, Wuhan 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuxiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Hubei Jiangxia Laboratory, Wuhan 430200, China"},{"name":"Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430207, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-6066","authenticated-orcid":false,"given":"Haibin","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Jiangxia Laboratory, Wuhan 430200, China"},{"name":"Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430207, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41564-020-0714-0","article-title":"The Continued Threat of Emerging Flaviviruses","volume":"5","author":"Pierson","year":"2020","journal-title":"Nat. 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