{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:38:50Z","timestamp":1788514730413,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NFF205A0063505"],"award-info":[{"award-number":["NFF205A0063505"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20SA0064201"],"award-info":[{"award-number":["NNF20SA0064201"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["CF20-476 0045"],"award-info":[{"award-number":["CF20-476 0045"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["SARF2021"],"award-info":[{"award-number":["SARF2021"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsberg Foundation","doi-asserted-by":"publisher","award":["NFF205A0063505"],"award-info":[{"award-number":["NFF205A0063505"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsberg Foundation","doi-asserted-by":"publisher","award":["NNF20SA0064201"],"award-info":[{"award-number":["NNF20SA0064201"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsberg Foundation","doi-asserted-by":"publisher","award":["CF20-476 0045"],"award-info":[{"award-number":["CF20-476 0045"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsberg Foundation","doi-asserted-by":"publisher","award":["SARF2021"],"award-info":[{"award-number":["SARF2021"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Research Foundation","doi-asserted-by":"publisher","award":["NFF205A0063505"],"award-info":[{"award-number":["NFF205A0063505"]}],"id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Research Foundation","doi-asserted-by":"publisher","award":["NNF20SA0064201"],"award-info":[{"award-number":["NNF20SA0064201"]}],"id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Research Foundation","doi-asserted-by":"publisher","award":["CF20-476 0045"],"award-info":[{"award-number":["CF20-476 0045"]}],"id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Research Foundation","doi-asserted-by":"publisher","award":["SARF2021"],"award-info":[{"award-number":["SARF2021"]}],"id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>To accommodate waning COVID-19 vaccine immunity to emerging SARS-CoV-2 variants, variant-adapted mRNA vaccines have been introduced. Here, we examine serological responses to the BA.1 and BA.4-5 Omicron variant-adapted BNT162b2 COVID-19 vaccines in people with lymphoid malignancies. We included 233 patients with lymphoid malignancies (chronic lymphocytic B-cell leukemia: 73 (31.3%), lymphoma: 89 (38.2%), multiple myeloma\/amyloidosis: 71 (30.5%)), who received an Omicron-adapted mRNA-based COVID-19 vaccine. IgG and neutralizing antibodies specific for the receptor-binding domain (RBD) of SARS-CoV-2 were measured using ELISA-based methods. Differences in antibody concentrations and neutralizing capacity and associations with risk factors were assessed using mixed-effects models. Over the period of vaccination with an Omicron-adapted COVID-19 vaccine, the predicted mean concentration of anti-RBD IgG increased by 0.09 log10 AU\/mL\/month (95% CI: 0.07; 0.11) in patients with lymphoid malignancies across diagnoses. The predicted mean neutralizing capacity increased by 0.9 percent points\/month (95% CI: 0.2; 1.6). We found no associations between the increase in antibody concentration or neutralizing capacity and the variant included in the adapted vaccine. In conclusion, a discrete increase in antibody concentrations and neutralizing capacity was found over the course of Omicron-adapted vaccination in patients with lymphoid malignancies regardless of the adapted vaccine variant, indicating a beneficial effect of Omicron-adapted booster vaccination in this population.<\/jats:p>","DOI":"10.3390\/v16010011","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T11:24:33Z","timestamp":1703071473000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Humoral Immune Responses after an Omicron-Adapted Booster BNT162b2 Vaccination in Patients with Lymphoid Malignancies"],"prefix":"10.3390","volume":"16","author":[{"given":"Line Dam","family":"Heftdal","sequence":"first","affiliation":[{"name":"Viro-Immunology Research Unit, Department of Infectious Diseases, Section 8632, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"},{"name":"Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"},{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaloees Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-4522","authenticated-orcid":false,"given":"Cecilie Bo","family":"Hansen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Ole Maaloees Vej 26, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-3442","authenticated-orcid":false,"given":"Sebastian Rask","family":"Hamm","sequence":"additional","affiliation":[{"name":"Viro-Immunology Research Unit, Department of Infectious Diseases, Section 8632, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-4976","authenticated-orcid":false,"given":"Laura","family":"P\u00e9rez-Al\u00f3s","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Ole Maaloees Vej 26, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamille","family":"Fogh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"},{"name":"Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Pries-Heje","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-6268","authenticated-orcid":false,"given":"Rasmus Bo","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"},{"name":"Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-0643","authenticated-orcid":false,"given":"Dina Leth","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Viro-Immunology Research Unit, Department of Infectious Diseases, Section 8632, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-1257","authenticated-orcid":false,"given":"Anne Ortved","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-3851","authenticated-orcid":false,"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"},{"name":"Department of Clinical Immunology, Section 2034, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-5027","authenticated-orcid":false,"given":"Ruth","family":"Frikke-Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"},{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Section 2034, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Hilsted","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-8586","authenticated-orcid":false,"given":"Peter","family":"Garred","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, Ole Maaloees Vej 26, 2200 Copenhagen N, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"},{"name":"Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 11, 2730 Herlev, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Sabin","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, UCL, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-7455","authenticated-orcid":false,"given":"Susanne Dam","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Viro-Immunology Research Unit, Department of Infectious Diseases, Section 8632, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"},{"name":"Department of Surgical Gastroenterology and Transplantation, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-9601","authenticated-orcid":false,"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Oe, Denmark"},{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaloees Vej 5, 2200 Copenhagen N, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"ref_1","unstructured":"(2023, June 05). Statement on the Fifteenth Meeting of the IHR (2005) Emergency Committee on the COVID-19 Pandemic. Available online: https:\/\/www.who.int\/news\/item\/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic?adgroupsurvey=%7Badgroupsurvey%7Dgclid=Cj0KCQjwj_ajBhCqARIsAA37s0z3Y6LqRWqMyRh_AAF45q23xZdgQ1OUcWPkm-lUuN7Ic34MHYQGF5saAkU7EALw_wcB."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1016\/S2468-2667(23)00079-8","article-title":"Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: A retrospective cohort study using the OpenSAFELY platform","volume":"8","author":"Nab","year":"2023","journal-title":"Lancet Public Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1182\/blood.2021014124","article-title":"COVID-19 in vaccinated adult patients with hematological malignancies: Preliminary results from EPICOVIDEHA","volume":"139","author":"Pagano","year":"2022","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Krekeler, C., Reitnauer, L., Bacher, U., Khandanpour, C., Steger, L., Boeckel, G.R., Klosner, J., Tepasse, P.R., Kemper, M., and Hennies, M.T. (2022). Efficacy of COVID-19 Booster Vaccines in Patients with Hematologic Malignancies: Experiences in a Real-World Scenario. Cancers, 14, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/36428605\/.","DOI":"10.3390\/cancers14225512"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/ejh.13986","article-title":"Humoral and cellular immune responses after three or four doses of BNT162b2 in patients with hematological malignancies","volume":"111","author":"Heftdal","year":"2023","journal-title":"Eur. J. Haematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2310650","DOI":"10.1001\/jamanetworkopen.2023.10650","article-title":"Evaluation of Waning of SARS-CoV-2 Vaccine\u2013Induced Immunity: A Systematic Review and Meta-analysis","volume":"6","author":"Menegale","year":"2023","journal-title":"JAMA Net. Open"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kozlov, M. (2023). Should COVID vaccines be given yearly? Proposal divides US scientists. Nature, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/36707704\/.","DOI":"10.1038\/d41586-023-00234-7"},{"key":"ref_8","first-page":"1614","article-title":"Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors","volume":"131","author":"Armenteros","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20667","DOI":"10.2807\/1560-7917.ES2014.19.1.20667","article-title":"The danish microbiology database (MIBA) 2010 to 2013","volume":"19","author":"Voldstedlund","year":"2014","journal-title":"Eurosurveillance"},{"key":"ref_10","first-page":"2","article-title":"The Danish vaccination register","volume":"17","author":"Jakobsen","year":"2012","journal-title":"Eurosurveillance"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/joim.13366","article-title":"Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming","volume":"290","author":"Hansen","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_12","unstructured":"(2019). R Foundation for Statistical Computing, R Core Team. Available online: https:\/\/www.scirp.org\/(S(lz5mqp453edsnp55rrgjct55))\/reference\/ReferencesPapers.aspx?ReferenceID=2631126."},{"key":"ref_13","unstructured":"(2021, November 04). A Grammar of Data Manipulation [R Package Dplyr Version 1.0.7]. Available online: https:\/\/cran.r-project.org\/package=dplyr."},{"key":"ref_14","unstructured":"(2023, June 22). Tests in Linear Mixed Effects Models [R Package lmerTest Version 3.1-3]. Available online: https:\/\/cran.r-project.org\/package=lmerTest."},{"key":"ref_15","unstructured":"Xiao, N. (2022, August 27). Scientific Journal and Sci-Fi Themed Color Palettes for \u2018ggplot2\u2019 [R Package Ggsci Version 2.9]. Available online: https:\/\/cran.r-project.org\/package=ggsci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S1473-3099(23)00058-0","article-title":"Long-term COVID-19 booster effectiveness by infection history and clinical vulnerability and immune imprinting: A retrospective population-based cohort study","volume":"23","author":"Chemaitelly","year":"2023","journal-title":"Lancet Infect Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"King, S.M., Bryan, S.P., Hilchey, S.P., Wang, J., and Zand, M.S. (2023). First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2. Pathogens, 12, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/36839441\/.","DOI":"10.3390\/pathogens12020169"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1038\/s41467-023-41342-2","article-title":"Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk","volume":"14","author":"Hansen","year":"2023","journal-title":"Nat. Commun"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/infdis\/jiad111","article-title":"The Journal of Infectious Diseases BRIEF REPORT Bivalent COVID-19 vaccine antibody responses to Omicron variants suggest that responses to divergent variants would be improved with matched vaccine antigens","volume":"228","author":"Wang","year":"2023","journal-title":"J. Infect Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/cid\/ciad402","article-title":"Omicron variant-specific serological imprinting following BA.1 or BA.4\/5 bivalent vaccination and previous SARS-CoV-2 infection: A cohort study","volume":"77","author":"Baerends","year":"2023","journal-title":"Clin. Infect Dis."},{"key":"ref_21","unstructured":"(2023, October 03). Available online: https:\/\/www.sst.dk\/-\/media\/Udgivelser\/2022\/Corona\/Vaccination\/Efteraar\/Anbefalinger-vaccinationsprogram-efteraar-2022.ashx."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:42:24Z","timestamp":1760132544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["v16010011"],"URL":"https:\/\/doi.org\/10.3390\/v16010011","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,20]]}}}