{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:33:12Z","timestamp":1762432392336,"version":"build-2065373602"},"reference-count":111,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federation BioST from Reunion Island University (ZIKAPONE project)","award":["DIRED\/2021-1115","DIRED\/2021-0161"],"award-info":[{"award-number":["DIRED\/2021-1115","DIRED\/2021-0161"]}]},{"name":"R\u00e9union University (Ecole doctorale STS)","award":["DIRED\/2021-1115","DIRED\/2021-0161"],"award-info":[{"award-number":["DIRED\/2021-1115","DIRED\/2021-0161"]}]},{"name":"R\u00e9gion R\u00e9union Council","award":["DIRED\/2021-1115","DIRED\/2021-0161"],"award-info":[{"award-number":["DIRED\/2021-1115","DIRED\/2021-0161"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Zika virus (ZIKV) is a pathogenic member of the flavivirus family, with several unique characteristics. Unlike any other arbovirus, ZIKV can be transmitted sexually and maternally, and thus produce congenital syndromes (CZS) due to its neurotropism. This challenges the search for safe active molecules that can protect pregnant women and their fetuses. In this context, and in the absence of any existing treatment, it seemed worthwhile to test whether the known cytoprotective properties of adiponectin and its pharmacological analog, AdipoRon, could influence the outcome of ZIKV infection. We showed that both AdipoRon and adiponectin could significantly reduce the in vitro infection of A549 epithelial cells, a well-known cell model for flavivirus infection studies. This effect was particularly observed when a pre-treatment was carried out. Conversely, ZIKV revealed an ability to downregulate adiponectin receptor expression and thereby limit adiponectin signaling.<\/jats:p>","DOI":"10.3390\/v16010024","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:44:40Z","timestamp":1703220280000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression"],"prefix":"10.3390","volume":"16","author":[{"given":"Daed","family":"El Safadi","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-3486","authenticated-orcid":false,"given":"Gr\u00e9gorie","family":"Lebeau","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-345X","authenticated-orcid":false,"given":"Jonathan","family":"Turpin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La R\u00e9union, France"},{"name":"UMR 1188 Diab\u00e8te Ath\u00e9rothombose R\u00e9union Oc\u00e9an Indien (D\u00e9TROI), Campus Sant\u00e9 Universit\u00e9 de la R\u00e9union, Universit\u00e9 de La R\u00e9union, INSERM, 77 Avenue du Docteur Jean-Marie Dambreville, 97410 Saint-Pierre, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lefebvre d\u2019Hellencourt","sequence":"additional","affiliation":[{"name":"UMR 1188 Diab\u00e8te Ath\u00e9rothombose R\u00e9union Oc\u00e9an Indien (D\u00e9TROI), Campus Sant\u00e9 Universit\u00e9 de la R\u00e9union, Universit\u00e9 de La R\u00e9union, INSERM, 77 Avenue du Docteur Jean-Marie Dambreville, 97410 Saint-Pierre, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-518X","authenticated-orcid":false,"given":"Nicolas","family":"Diotel","sequence":"additional","affiliation":[{"name":"UMR 1188 Diab\u00e8te Ath\u00e9rothombose R\u00e9union Oc\u00e9an Indien (D\u00e9TROI), Campus Sant\u00e9 Universit\u00e9 de la R\u00e9union, Universit\u00e9 de La R\u00e9union, INSERM, 77 Avenue du Docteur Jean-Marie Dambreville, 97410 Saint-Pierre, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-8635","authenticated-orcid":false,"given":"Wildriss","family":"Viranaicken","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La R\u00e9union, France"},{"name":"UMR 1188 Diab\u00e8te Ath\u00e9rothombose R\u00e9union Oc\u00e9an Indien (D\u00e9TROI), Campus Sant\u00e9 Universit\u00e9 de la R\u00e9union, Universit\u00e9 de La R\u00e9union, INSERM, 77 Avenue du Docteur Jean-Marie Dambreville, 97410 Saint-Pierre, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-1716","authenticated-orcid":false,"given":"Pascale","family":"Krejbich-Trotot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Universit\u00e9 de la R\u00e9union, INSERM U1187, CNRS UMR 9192, IRD UMR 249, 94791 Sainte Clotilde, La R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2017.03.001","article-title":"Zika Virus: History, Epidemiology, Transmission, and Clinical Presentation","volume":"308","author":"Song","year":"2017","journal-title":"J. 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