{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:34Z","timestamp":1790770354442,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gulbali Graduate Bridging Scheme","award":["MC-A025-5PL41"],"award-info":[{"award-number":["MC-A025-5PL41"]}]},{"name":"Gulbali Graduate Bridging Scheme","award":["DE210101145"],"award-info":[{"award-number":["DE210101145"]}]},{"name":"MRC","award":["MC-A025-5PL41"],"award-info":[{"award-number":["MC-A025-5PL41"]}]},{"name":"MRC","award":["DE210101145"],"award-info":[{"award-number":["DE210101145"]}]},{"name":"Australian Government","award":["MC-A025-5PL41"],"award-info":[{"award-number":["MC-A025-5PL41"]}]},{"name":"Australian Government","award":["DE210101145"],"award-info":[{"award-number":["DE210101145"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Australian bat lyssavirus (ABLV) shows similar clinical symptoms as rabies, but there are currently no protein structures available for ABLV proteins. In lyssaviruses, the interaction between nucleoprotein (N) and phosphoprotein (N) in the absence of RNA generates a complex (N0P) that is crucial for viral assembly, and understanding the interface between these two proteins has the potential to provide insight into a key feature: the viral lifecycle. In this study, we used recombinant chimeric protein expression and X-ray crystallography to determine the structure of ABLV nucleoprotein bound to residues 1\u201340 of its phosphoprotein chaperone. Comparison of our results with the recently generated structure of RABV CVS-11 N0P demonstrated a highly conserved interface in this complex. Because the N0P interface is conserved in the lyssaviruses of phylogroup I, it is an attractive therapeutic target for multiple rabies-causing viral species.<\/jats:p>","DOI":"10.3390\/v16010033","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:44:15Z","timestamp":1703450655000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural Determination of the Australian Bat Lyssavirus Nucleoprotein and Phosphoprotein Complex"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-2462","authenticated-orcid":false,"given":"Camilla M.","family":"Donnelly","sequence":"first","affiliation":[{"name":"School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"},{"name":"Diagnostics, Surveillance and Response, Australian Centre for Disease Preparedness, CSIRO, Geelong, VIC 3219, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Stewart","sequence":"additional","affiliation":[{"name":"MRC Laboratory of Molecular Biology, Francis Crick Ave., Cambridge Biomedical Campus, Cambridge CB2 0QH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-4273","authenticated-orcid":false,"given":"Justin A.","family":"Roby","sequence":"additional","affiliation":[{"name":"School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-8031","authenticated-orcid":false,"given":"Vinod","family":"Sundaramoorthy","sequence":"additional","affiliation":[{"name":"Diagnostics, Surveillance and Response, Australian Centre for Disease Preparedness, CSIRO, Geelong, VIC 3219, Australia"},{"name":"School of Medicine, Deakin University, Geelong, VIC 3216, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade K.","family":"Forwood","sequence":"additional","affiliation":[{"name":"School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3201\/eid0204.960408","article-title":"Encephalitis caused by a Lyssavirus in fruit bats in Australia","volume":"2","author":"Fraser","year":"1996","journal-title":"Emerg. 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