{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:20:40Z","timestamp":1791490840762,"version":"4.3.4"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Budget of the Russian Federation allocated for the implementation of the Polio Eradication Programme in the Russian Federation","award":["22-15-00230"],"award-info":[{"award-number":["22-15-00230"]}]},{"name":"WHO Polio Eradication Program","award":["22-15-00230"],"award-info":[{"award-number":["22-15-00230"]}]},{"name":"WHO Regional Office for Europe","award":["22-15-00230"],"award-info":[{"award-number":["22-15-00230"]}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-15-00230"],"award-info":[{"award-number":["22-15-00230"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>More than 100 types of non-polio enteroviruses (NPEVs) are ubiquitous in the human population and cause a variety of symptoms ranging from very mild to meningitis and acute flaccid paralysis (AFP). Much of the information regarding diverse pathogenic properties of NPEVs comes from the surveillance of poliovirus, which also yields NPEV. The analysis of 265 NPEV isolations from 10,433 AFP cases over 24 years of surveillance and more than 2500 NPEV findings in patients without severe neurological lesions suggests that types EV-A71, E13, and E25 were significantly associated with AFP. EV-A71 was also significantly more common among AFP patients who had fever at the onset and residual paralysis compared to all AFP cases. In addition, a significant disparity was noticed between types that were common in humans (CV-A2, CVA9, EV-A71, E9, and E30) or in sewage (CVA7, E3, E7, E11, E12, and E19). Therefore, there is significant evidence of non-polio viruses being implicated in severe neurological lesions, but further multicenter studies using uniform methodology are needed for a definitive conclusion.<\/jats:p>","DOI":"10.3390\/v16010135","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T03:50:56Z","timestamp":1705549856000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Non-Polio Enteroviruses Isolated by Acute Flaccid Paralysis Surveillance Laboratories in the Russian Federation in 1998\u20132021: Distinct Epidemiological Features of Types"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-4827","authenticated-orcid":false,"given":"Olga E.","family":"Ivanova","sequence":"first","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"},{"name":"Department of Organization and Technology of Production of Immunobiological Preparations, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana P.","family":"Eremeeva","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda S.","family":"Morozova","sequence":"additional","affiliation":[{"name":"The Federal Budgetary Health Institution \u201cFederal Center of Hygiene and Epidemiology\u201d of the Federal Office for Inspectorate in the Field of Customers and Human Well-Being Protection\u201d(FBHI FCH&E), 117105 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia M.","family":"Mikhailova","sequence":"additional","affiliation":[{"name":"The Federal Budgetary Health Institution \u201cFederal Center of Hygiene and Epidemiology\u201d of the Federal Office for Inspectorate in the Field of Customers and Human Well-Being Protection\u201d(FBHI FCH&E), 117105 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov I.","family":"Kozlovskaya","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"},{"name":"Department of Organization and Technology of Production of Immunobiological Preparations, Institute for Translational Medicine and Biotechnology, First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Y.","family":"Baikova","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armen K.","family":"Shakaryan","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"},{"name":"Department of Children\u0374s Infectious Diseases, Pediatric Faculty, Pirogov Russian National Research Medical University, 119121 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandr Y.","family":"Krasota","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"},{"name":"Belozersky Institute of Physical-Chemical Biology, Lomonosov Moscow State University, 119899 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Korotkova","sequence":"additional","affiliation":[{"name":"Belozersky Institute of Physical-Chemical Biology, Lomonosov Moscow State University, 119899 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta V.","family":"Yakovchuk","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Y.","family":"Shustova","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Scientific Institution \u201cChumakov Federal Center for Research and Development of Immune-and-Biological Products of the Russian Academy of Sciences\u201d (Institute of Poliomyelitis) (FSASI \u201cChumakov FSC R&D IBP RAS\u201d), 108819 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Lukashev","sequence":"additional","affiliation":[{"name":"Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"},{"name":"Research Institute for Systems Biology and Medicine, 117246 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref_1","unstructured":"International Committee on Taxonomy of Viruses (ICTV) [Electronic Resource] (2024, January 10). 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