{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:13:00Z","timestamp":1790709180064,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["R15 AI131202"],"award-info":[{"award-number":["R15 AI131202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM144265"],"award-info":[{"award-number":["P20 GM144265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM103423"],"award-info":[{"award-number":["P20 GM103423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health","doi-asserted-by":"publisher","award":["R15 AI131202"],"award-info":[{"award-number":["R15 AI131202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM144265"],"award-info":[{"award-number":["P20 GM144265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM103423"],"award-info":[{"award-number":["P20 GM103423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Influenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies on the contribution of the innate immune response to influenza A virus (IAV) to viral pathogenesis may yield new antiviral strategies. Zebrafish larvae are useful models for studying the innate immune response to pathogens, including IAV, in vivo. Here, we demonstrate how Color-flu, four fluorescent IAV strains originally developed for mice, can be used to study the host response to infection by simultaneously monitoring infected cells, neutrophils, and macrophages in vivo. Using this model, we show how the angiotensin-converting enzyme inhibitor, ramipril, and mitophagy inhibitor, MDIVI-1, improved survival, decreased viral burden, and improved the respiratory burst response to IAV infection. The Color-flu zebrafish larvae model of IAV infection is complementary to other models where the dynamics of infection and the response of innate immune cells can be visualized in a transparent host in vivo.<\/jats:p>","DOI":"10.3390\/v16010155","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T03:50:22Z","timestamp":1705895422000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Color-Flu Fluorescent Reporter Influenza A Viruses Allow for In Vivo Studies of Innate Immune Function in Zebrafish"],"prefix":"10.3390","volume":"16","author":[{"given":"Brandy-Lee","family":"Soos","sequence":"first","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Ballinger","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykayla","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Foreman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianna","family":"Grampone","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Weafer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Aylesworth","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-1336","authenticated-orcid":false,"given":"Benjamin L.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA"},{"name":"Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 04469, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/cid\/cix1060","article-title":"Seasonal Incidence of Symptomatic Influenza in the United States","volume":"66","author":"Tokars","year":"2018","journal-title":"Clin. 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