{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:26:15Z","timestamp":1783664775455,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Agency for Research on AIDS and Viral Hepatitis and Emerging Infectious diseases","award":["ANRS 12345"],"award-info":[{"award-number":["ANRS 12345"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pregnant women identified to carry hepatitis B surface antigen (HBsAg) should be linked to care for the determination of the need for long-term antiviral therapy (LTT). We assessed the performance of simplified criteria, free from HBV DNA quantification, to select women eligible for LTT using different international guidelines as a reference. A retrospective analysis of HBV-infected pregnant women enrolled in the phase 4 ANRS TA-PROHM study was conducted in Cambodia. Sensitivity, specificity, and AUROC were computed to compare three simplified criteria (TREAT-B, HBcrAg\/ALT, and TA-PROHM) with the American (AASLD) and European (EASL) guidelines as a reference. An additional assessment was performed at 6 months postpartum. Of 651 HBsAg-positive women, 209 (32%) received peripartum antiviral prophylaxis using tenofovir disoproxil fumarate (TDF). During pregnancy, 9% and 12% of women were eligible for LTT according to AASLD and EASL guidelines, respectively; 21% and 24% of women were eligible for prophylactic TDF and 2% and 5% in those ineligible (p &lt; 0.001). Using the AASLD guidelines, the AUROC of TREAT-B, HBcrAg\/ALT, and TA-PROHM scores were 0.88 (95%CI, 0.85\u20130.90), 0.90 (95%CI, 0.87\u20130.92), and 0.76 (95%CI, 0.73\u20130.80), respectively. Using the EASL guidelines, the AUROCs were lower: 0.73 (95%CI, 0.69\u20130.76), 0.76 (95%CI, 0.73\u20130.80), and 0.71 (95%CI, 0.67\u20130.74), respectively. Among those ineligible for prophylactic TDF, only 2% to 6% present an indication for LTT at 24 weeks postpartum. Few pregnant women are eligible for LTT, and the use of simplified criteria could represent an efficient triage option in decentralized areas to identify those negative for whom there is no urgent indication for LTT and focus on those positive for whom other exams must be conducted to confirm LTT indication.<\/jats:p>","DOI":"10.3390\/v16020194","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:11:27Z","timestamp":1706515887000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simplified Criteria to Assess Long-Term Antiviral Treatment Indication in Chronic HBV-Infected Pregnant Women in Cambodia"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-280X","authenticated-orcid":false,"given":"Jee-Seon","family":"Yang","sequence":"first","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"},{"name":"Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"Service de P\u00e9diatrie G\u00e9n\u00e9rale et Aval des Urgences, H\u00f4pital Armand Trousseau, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saren","family":"Sovann","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-4785","authenticated-orcid":false,"given":"Yusuke","family":"Shimakawa","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 d\u2019\u00c9pid\u00e9miologie des Maladies \u00c9mergentes, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sovann","family":"Nhoueng","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunnet","family":"Dim","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanlina","family":"Vong","sequence":"additional","affiliation":[{"name":"Calmette Hospital, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa","family":"Sann","sequence":"additional","affiliation":[{"name":"Calmette Hospital, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Guillebaud","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darapolin","family":"Vann","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunrith","family":"Touch","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyna","family":"Chea","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wathanak Pisey Choupoan","family":"Phirum","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"ANRS|Maladies Infectieuses Emergentes, 75000 Paris, France"},{"name":"Internal Medicine Department, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Paul","sequence":"additional","affiliation":[{"name":"ANRS|Maladies Infectieuses Emergentes, 75000 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leangchhun","family":"Khun","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantana","family":"Yay","sequence":"additional","affiliation":[{"name":"Jayavarman VII Hospital, Siem Reap 17259, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Laurent","sequence":"additional","affiliation":[{"name":"Direction Department, Foundation Children\u2019s Hospital Kantha Bopha, Phnom Penh 12000, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samsorphea","family":"Chhun","sequence":"additional","affiliation":[{"name":"Calmette Hospital, Phnom Penh 12201, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Borand","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge, Phnom Penh 12201, Cambodia"},{"name":"Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Segeral","sequence":"additional","affiliation":[{"name":"ANRS|Maladies Infectieuses Emergentes, 75000 Paris, France"},{"name":"HIV Unit, Infectious Diseases Department, Geneva University Hospital, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). 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