{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:54:30Z","timestamp":1787086470796,"version":"build-2736575974"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wuhan Knowledge Innovation Special Basic Research Project","award":["2023020201010118"],"award-info":[{"award-number":["2023020201010118"]}]},{"name":"Wuhan Knowledge Innovation Special Basic Research Project","award":["202209FE06"],"award-info":[{"award-number":["202209FE06"]}]},{"name":"Wuhan Knowledge Innovation Special Basic Research Project","award":["2022KF16"],"award-info":[{"award-number":["2022KF16"]}]},{"name":"the Open Funding of the Key Laboratory of Fermentation Engineering (Ministry of Education)","award":["2023020201010118"],"award-info":[{"award-number":["2023020201010118"]}]},{"name":"the Open Funding of the Key Laboratory of Fermentation Engineering (Ministry of Education)","award":["202209FE06"],"award-info":[{"award-number":["202209FE06"]}]},{"name":"the Open Funding of the Key Laboratory of Fermentation Engineering (Ministry of Education)","award":["2022KF16"],"award-info":[{"award-number":["2022KF16"]}]},{"name":"the Cooperative Innovation Center of Industrial Fermentation (Ministry of Education &amp; Hubei Province), China","award":["2023020201010118"],"award-info":[{"award-number":["2023020201010118"]}]},{"name":"the Cooperative Innovation Center of Industrial Fermentation (Ministry of Education &amp; Hubei Province), China","award":["202209FE06"],"award-info":[{"award-number":["202209FE06"]}]},{"name":"the Cooperative Innovation Center of Industrial Fermentation (Ministry of Education &amp; Hubei Province), China","award":["2022KF16"],"award-info":[{"award-number":["2022KF16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases demonstrating a \u201ccytokine storm\u201d, an upsurge of pro-inflammatory cytokines in the bloodstream. NLRP3 inflammasomes, integral to the innate immune system, are speculated to be activated by SARS-CoV-2 within host cells. This review investigates the potential correlation between NLRP3 inflammasomes and COVID-19, exploring the cellular and molecular mechanisms through which SARS-CoV-2 triggers their activation. Furthermore, promising strategies targeting NLRP3 inflammasomes are proposed to mitigate the excessive inflammatory response provoked by SARS-CoV-2 infection. By synthesizing existing studies, this paper offers insights into NLRP3 as a therapeutic target, elucidating the interplay between COVID-19 and its pathophysiology. It serves as a valuable reference for future clinical approaches in addressing COVID-19 by targeting NLRP3, thus providing potential avenues for therapeutic intervention.<\/jats:p>","DOI":"10.3390\/v16020213","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:41:59Z","timestamp":1706694119000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigating the Nexus of NLRP3 Inflammasomes and COVID-19 Pathogenesis: Unraveling Molecular Triggers and Therapeutic Strategies"],"prefix":"10.3390","volume":"16","author":[{"given":"Qun","family":"He","sequence":"first","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Hu","sequence":"additional","affiliation":[{"name":"Sinopharm Animal Health Corporation Ltd., Wuhan 430075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-2767","authenticated-orcid":false,"given":"Kanghong","family":"Hu","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Yao","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanluo","family":"Li","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wei","sequence":"additional","affiliation":[{"name":"Sino-German Biomedical Center, National \u201c111\u201d Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/S2214-109X(23)00486-2","article-title":"Vaccinating international seafarers during the COVID-19 pandemic","volume":"12","author":"Lucas","year":"2024","journal-title":"Lancet Glob. 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