{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:17:01Z","timestamp":1790295421375,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>We aimed to assess the temporal trends of incident syphilis and its associated risk factors among men with HIV (Human Immunodeficiency Virus) in Korea during the COVID-19 pandemic. We conducted a retrospective cohort study of men with HIV attending an HIV clinic in Korea between 2005 and 2022. Of 767 men with HIV, 499 were included and contributed 3220 person-years (PY) of the observation period. Eighty-two patients were diagnosed with incident syphilis, with an overall incidence of 2.55\/100 PY (95% confidence interval [CI] 20.56\u201331.53). The incidence of syphilis per 100 PY gradually decreased from 2.43 (0.79\u20137.42) in 2005\u20132007 to 1.85 (1.08\u20133.17) in 2014\u20132016; however, it increased to 3.0 (1.99\u20134.53) in 2017\u20132019, and further to 3.33 (2.26\u20134.89) in 2020\u20132022. A multivariate analysis identified young age (\u226430 years versus &gt;50, adjusted HR 6.27, 95% CI 2.38\u201316.56, p &lt; 0.001), treponemal test positive at baseline (2.33, 1.48\u20133.67, p &lt; 0.001), men who have sex with men (2.36, 1.34\u20134.16, p = 0.003), and history of incarceration (2.62, 1.21\u20135.67, p = 0.015) as risk factors for incident syphilis. Recently, syphilis incidence in men with HIV has increased in Korea, especially in young patients and at-risk groups, highlighting the need for enhanced regular screening and targeted behavioral interventions among these populations.<\/jats:p>","DOI":"10.3390\/v16020265","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:47:09Z","timestamp":1707277629000},"page":"265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Temporal Trends in Syphilis Incidence among Men with HIV in Busan, Korea, 2005\u20132022: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-3628","authenticated-orcid":false,"given":"Sun Hee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Seog","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Hoi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pusan National University School of Medicine, Busan 49241, Republic of Korea"},{"name":"Biomedical Informatics Unit, Pusan National University School of Medicine, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hwa","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Pusan National University School of Medicine, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-5453","authenticated-orcid":false,"given":"Jin Suk","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-5109","authenticated-orcid":false,"given":"Hyunjin","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Prevention Medicine, Donga University School of Medicine, Donga University Hospital, Busan 49201, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tao, Y.T., Gao, T.Y., Li, H.Y., Ma, Y.T., Li, H.J., Xian-Yu, C.Y., Deng, N.J., and Zhang, C. 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