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nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take place at early stages of the infection. Poxviruses, also members of the NCLDV and represented by vaccinia virus (VACV), are large, enveloped, double-stranded DNA viruses. Poxviruses were considered unique in having an elaborate entry-fusion complex (EFC) composed of 11 highly conserved proteins integrated into the membrane of mature virions. Recent advances in methodological techniques have again revealed several connections between VACV EFC proteins. In this study, we explored the possibility of an analogous ASFV EFC by identifying ten candidate proteins exhibiting structural similarities with VACV EFC proteins. This could reveal key functions of these ASFV proteins, drawing attention to shared features between the two virus families, suggesting the potential existence of an ASFV entry-fusion complex.<\/jats:p>","DOI":"10.3390\/v16030349","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T07:51:39Z","timestamp":1708933899000},"page":"349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of a Potential Entry-Fusion Complex Based on Sequence Homology of African Swine Fever and Vaccinia Virus"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-4580","authenticated-orcid":false,"given":"Jes\u00fas","family":"Urquiza","sequence":"first","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, INIA-CSIC, Centro Nacional Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, Ctra. de la Coru\u00f1a Km 7.5, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Cuesta-Geijo","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, INIA-CSIC, Centro Nacional Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, Ctra. de la Coru\u00f1a Km 7.5, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-5662","authenticated-orcid":false,"given":"Isabel","family":"Garc\u00eda-Dorival","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, INIA-CSIC, Centro Nacional Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, Ctra. de la Coru\u00f1a Km 7.5, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad BICS, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Consejo Superior de Investigaciones Cient\u00edficas, Ramiro de Maeztu 9, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"del Puerto","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, INIA-CSIC, Centro Nacional Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, Ctra. de la Coru\u00f1a Km 7.5, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-3319","authenticated-orcid":false,"given":"Jos\u00e9 Fernando","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad BICS, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Consejo Superior de Investigaciones Cient\u00edficas, Ramiro de Maeztu 9, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-6177","authenticated-orcid":false,"given":"Covadonga","family":"Alonso","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, INIA-CSIC, Centro Nacional Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria, Ctra. de la Coru\u00f1a Km 7.5, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0368-1742(21)80031-4","article-title":"On a form of swine fever occurring in British East Africa (Kenya colony)","volume":"34","author":"Montgomery","year":"1921","journal-title":"J. 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