{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:15:23Z","timestamp":1792984523902,"version":"4.5.0"},"reference-count":227,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Witten\/Herdecke University","award":["UW\/H-IFF-2023-62"],"award-info":[{"award-number":["UW\/H-IFF-2023-62"]}]},{"name":"Witten\/Herdecke University","award":["IFF2023-77"],"award-info":[{"award-number":["IFF2023-77"]}]},{"name":"Witten\/Herdecke University","award":["EH 192\/5-3"],"award-info":[{"award-number":["EH 192\/5-3"]}]},{"name":"DFG grant","award":["UW\/H-IFF-2023-62"],"award-info":[{"award-number":["UW\/H-IFF-2023-62"]}]},{"name":"DFG grant","award":["IFF2023-77"],"award-info":[{"award-number":["IFF2023-77"]}]},{"name":"DFG grant","award":["EH 192\/5-3"],"award-info":[{"award-number":["EH 192\/5-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Adenoviruses (Ad) have the potential to induce severe infections in vulnerable patient groups. Therefore, understanding Ad biology and antiviral processes is important to comprehend the signaling cascades during an infection and to initiate appropriate diagnostic and therapeutic interventions. In addition, Ad vector-based vaccines have revealed significant potential in generating robust immune protection and recombinant Ad vectors facilitate efficient gene transfer to treat genetic diseases and are used as oncolytic viruses to treat cancer. Continuous improvements in gene delivery capacity, coupled with advancements in production methods, have enabled widespread application in cancer therapy, vaccine development, and gene therapy on a large scale. This review provides a comprehensive overview of the virus biology, and several aspects of recombinant Ad vectors, as well as the development of Ad vector, are discussed. Moreover, we focus on those Ads that were used in preclinical and clinical applications including regenerative medicine, vaccine development, genome engineering, treatment of genetic diseases, and virotherapy in tumor treatment.<\/jats:p>","DOI":"10.3390\/v16030377","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T06:14:22Z","timestamp":1709100862000},"page":"377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Advances of Recombinant Adenoviral Vectors in Preclinical and Clinical Applications"],"prefix":"10.3390","volume":"16","author":[{"given":"Luca","family":"Scarsella","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"},{"name":"Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department Human Medicine, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"},{"name":"Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Science (ZBAF), Department of Human Medicine, Faculty of Medicine, Witten\/Herdecke University, 58453 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ehrke-Schulz","sequence":"additional","affiliation":[{"name":"Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department Human Medicine, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Paulussen","sequence":"additional","affiliation":[{"name":"Chair of Pediatrics, University Children\u2019s Hospital, Vestische Kinder- und Jugendklinik Datteln, Witten\/Herdecke University, 45711 Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge C.","family":"Thal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Ehrhardt","sequence":"additional","affiliation":[{"name":"Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department Human Medicine, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Aydin","sequence":"additional","affiliation":[{"name":"Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department Human Medicine, Faculty of Health, Witten\/Herdecke University, 58453 Witten, Germany"},{"name":"Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Science (ZBAF), Department of Human Medicine, Faculty of Medicine, Witten\/Herdecke University, 58453 Witten, Germany"},{"name":"Chair of Pediatrics, University Children\u2019s Hospital, Vestische Kinder- und Jugendklinik Datteln, Witten\/Herdecke University, 45711 Datteln, Germany"},{"name":"Institute for Medical Laboratory Diagnostics, Center for Clinical and Translational Research, Helios University Hospital Wuppertal, Witten\/Herdecke University, 42283 Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3181\/00379727-84-20714","article-title":"Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture","volume":"84","author":"Rowe","year":"1953","journal-title":"Proc. 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