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While these responses are predictable due to the high homology between SARS-CoV-2 and other CoVs, the impact of these responses on susceptibility to SARS-CoV-2 infection in cancer patients is unclear. To investigate the influence of prior HCoV infection on anti-SARS-CoV-2 Ab responses among COVID-19 asymptomatic individuals with cancer and controls without cancers, we utilized the VirScan technology in which phage immunoprecipitation and sequencing (PhIP-seq) of longitudinal plasma samples was performed to investigate high-resolution (i.e., epitope level) humoral CoV responses. Despite testing positive for anti-SARS-CoV-2 Ab in the plasma, a majority of the participants were asymptomatic for COVID-19 with no prior history of COVID-19 diagnosis. Although the magnitudes of the anti-SARS-CoV-2 Ab responses were lower in individuals with Kaposi sarcoma (KS) compared to non-KS cancer individuals and those without cancer, the HCoV Ab repertoire was similar between individuals with and without cancer independent of age, sex, HIV status, and chemotherapy. The magnitudes of the anti-spike HCoV responses showed a strong positive association with those of the anti-SARS-CoV-2 spike in cancer patients, and only a weak association in non-cancer patients, suggesting that prior infection with HCoVs might play a role in limiting SARS-CoV-2 infection and COVID-19 disease severity.<\/jats:p>","DOI":"10.3390\/v16030448","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:23:11Z","timestamp":1710336191000},"page":"448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Viral Epitope Scanning Reveals Correlation between Seasonal HCoVs and SARS-CoV-2 Antibody Responses among Cancer and Non-Cancer Patients"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-6595","authenticated-orcid":false,"given":"Salum J.","family":"Lidenge","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Training, and Consultancy, Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"},{"name":"Department of Clinical Oncology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-6059","authenticated-orcid":false,"given":"Dicle","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-8461","authenticated-orcid":false,"given":"Sydney J.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"},{"name":"School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68516, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-4128","authenticated-orcid":false,"given":"Owen","family":"Ngalamika","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Division, University Teaching Hospital, University of Zambia School of Medicine, Lusaka P.O. Box 50001, Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda B.","family":"Kweyamba","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Training, and Consultancy, Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chacha J.","family":"Mwita","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Training, and Consultancy, Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"For Yue","family":"Tso","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Oncology, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Mwaiselage","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Training, and Consultancy, Ocean Road Cancer Institute, Dar es Salaam P.O. Box 3592, Tanzania"},{"name":"Department of Clinical Oncology, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. 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Available online: https:\/\/www.worldometers.info\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41579-018-0118-9","article-title":"Origin and Evolution of Pathogenic Coronaviruses","volume":"17","author":"Cui","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yadav, R., Chaudhary, J.K., Jain, N., Chaudhary, P.K., Khanra, S., Dhamija, P., Sharma, A., Kumar, A., and Handu, S. (2021). Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19. Cells, 10.","DOI":"10.3390\/cells10040821"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"104490","DOI":"10.1016\/j.meegid.2020.104490","article-title":"Genetic Comparison among Various Coronavirus Strains for the Identification of Potential Vaccine Targets of SARS-CoV-2","volume":"89","author":"Kaur","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"691163","DOI":"10.3389\/fpubh.2021.691163","article-title":"Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot","volume":"9","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/infdis\/jiaa185","article-title":"Epidemiology of Seasonal Coronaviruses: Establishing the Context for the Emergence of Coronavirus Disease 2019","volume":"222","author":"Nickbakhsh","year":"2020","journal-title":"J. Infect Dis."},{"key":"ref_8","unstructured":"Hodgens, A., and Gupta, V. (2023). Severe Acute Respiratory Syndrome, StatPearls."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11547-020-01311-x","article-title":"Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), Influenza, and COVID-19, beyond the Lungs: A Review Article","volume":"126","author":"Lombardi","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1016\/S1473-3099(20)30484-9","article-title":"Comparing SARS-CoV-2 with SARS-CoV and Influenza Pandemics","volume":"20","author":"Petersen","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A New Coronavirus Associated with Human Respiratory Disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_14","first-page":"ofad34","article-title":"Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France","volume":"10","author":"Woudenberg","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-021-06785-2","article-title":"Coronavirus Seasonality, Respiratory Infections and Weather","volume":"21","author":"Nichols","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ijid.2020.10.104","article-title":"High Prevalence of Pre-Existing Serological Cross-Reactivity against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in Sub-Saharan Africa","volume":"102","author":"Tso","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-020-2550-z","article-title":"SARS-CoV-2-Specific T Cell Immunity in Cases of COVID-19 and SARS, and Uninfected Controls","volume":"584","author":"Tan","year":"2020","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41591-020-01143-2","article-title":"Characterization of Pre-Existing and Induced SARS-CoV-2-Specific CD8+ T Cells","volume":"27","author":"Schulien","year":"2021","journal-title":"Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s10875-021-00997-6","article-title":"Serologic Cross-Reactivity of SARS-CoV-2 with Endemic and Seasonal Betacoronaviruses","volume":"41","author":"Hicks","year":"2021","journal-title":"J. Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijid.2023.06.009","article-title":"Prepandemic Cross-Reactive Humoral Immunity to SARS-CoV-2 in Africa: Systematic Review and Meta-Analysis","volume":"134","author":"Ioannidis","year":"2023","journal-title":"Int. J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"107725","DOI":"10.1016\/j.celrep.2020.107725","article-title":"Cross-Reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections","volume":"31","author":"Lv","year":"2020","journal-title":"Cell Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1084\/jem.20151517","article-title":"Human T Cell Responses to Japanese Encephalitis Virus in Health and Disease","volume":"213","author":"Turtle","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular Immune Correlates of Protection against Symptomatic Pandemic Influenza","volume":"19","author":"Sridhar","year":"2013","journal-title":"Nat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2018.10.008","article-title":"Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages","volume":"24","author":"Zimmerman","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.1185181","article-title":"Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans","volume":"328","author":"Dejnirattisai","year":"2010","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"743003","DOI":"10.3389\/fpubh.2021.743003","article-title":"Differential Impact of COVID-19 Risk Factors on Ethnicities in the United States","volume":"9","author":"Athavale","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.1038\/s41467-020-19741-6","article-title":"Male Sex Identified by Global COVID-19 Meta-Analysis as a Risk Factor for Death and ITU Admission","volume":"11","author":"Peckham","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Starke, K.R., Petereit-Haack, G., Schubert, M., K\u00e4mpf, D., Schliebner, A., Hegewald, J., and Seidler, A. (2020). The Age-Related Risk of Severe Outcomes Due to Covid-19 Infection: A Rapid Review, Meta-Analysis, and Meta-Regression. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17165974"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e006434","DOI":"10.1136\/bmjgh-2021-006434","article-title":"The Isolated Effect of Age on the Risk of COVID-19 Severe Outcomes: A Systematic Review with Meta-Analysis","volume":"6","author":"Starke","year":"2021","journal-title":"BMJ Glob. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3373378","DOI":"10.21037\/apm-20-1662","article-title":"The Impact of the COVID-19 Pandemic on Lung Cancer Patients","volume":"9","author":"Sha","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_31","first-page":"452","article-title":"The Impact of the COVID-19 Pandemic on Cancer Patients","volume":"43","author":"Amer","year":"2020","journal-title":"Am. J. Clin. Oncol. Cancer Clin. Trials"},{"key":"ref_32","first-page":"100824","article-title":"COVID-19 Infection among Patients with Cancer in Australia from 2020 to 2022: A National Multicentre Cohort Study","volume":"38","author":"Hall","year":"2023","journal-title":"Lancet Reg. Health\u2014West. Pac."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S2213-8587(20)30405-8","article-title":"Risks of and Risk Factors for COVID-19 Disease in People with Diabetes: A Cohort Study of the Total Population of Scotland","volume":"9","author":"McGurnaghan","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.1016\/S2666-5247(23)00012-5","article-title":"Correlates of Protection against COVID-19 Infection and Intensity of Symptomatic Disease in Vaccinated Individuals Exposed to SARS-CoV-2 in Households in Israel (ICoFS): A Prospective Cohort Study","volume":"4","author":"Lustig","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"569611","DOI":"10.3389\/fimmu.2020.569611","article-title":"Immune Correlates of COVID-19 Control","volume":"11","author":"Poonia","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.13091","article-title":"Correlates of Protection against SARS-CoV-2 Infection and COVID-19 Disease","volume":"310","author":"Goldblatt","year":"2022","journal-title":"Immunol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11912-020-00934-7","article-title":"COVID-19 and Cancer: A Comprehensive Review","volume":"22","author":"Gosain","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/jamaoncol.2020.0980","article-title":"SARS-CoV-2 Transmission in Patients with Cancer at a Tertiary Care Hospital in Wuhan, China","volume":"6","author":"Yu","year":"2020","journal-title":"JAMA Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1470-2045(20)30096-6","article-title":"Cancer Patients in SARS-CoV-2 Infection: A Nationwide Analysis in China","volume":"21","author":"Liang","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40880-019-0411-7","article-title":"Current Cancer Situation in China: Good or Bad News from the 2018 Global Cancer Statistics?","volume":"39","author":"Feng","year":"2019","journal-title":"Cancer Commun"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of Comorbidities and Its Effects in Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer Immunoediting: Integrating Immunity\u2019s Roles in Cancer Suppression and Promotion","volume":"331","author":"Schreiber","year":"2011","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s40259-022-00529-7","article-title":"Passive Immunotherapy Against SARS-CoV-2: From Plasma-Based Therapy to Single Potent Antibodies in the Race to Stay Ahead of the Variants","volume":"36","author":"Strohl","year":"2022","journal-title":"BioDrugs"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1055457","DOI":"10.3389\/fimmu.2023.1055457","article-title":"Protective Roles and Protective Mechanisms of Neutralizing Antibodies against SARS-CoV-2 Infection and Their Potential Clinical Implications","volume":"14","author":"Abebe","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"ltab027","DOI":"10.1093\/immadv\/ltab027","article-title":"Human Neutralizing Antibodies for SARS-CoV-2 Prevention and Immunotherapy","volume":"2","author":"Zhou","year":"2022","journal-title":"Immunother. Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e57877","DOI":"10.7554\/eLife.57877","article-title":"Antibodies to SARS-CoV-2 and Their Potential for Therapeutic Passive Immunization","volume":"9","author":"Klasse","year":"2020","journal-title":"eLife"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tso, F.Y., Lidenge, S.J., Poppe, L.K., Pe\u00f1a, P.B., Privatt, S.R., Bennett, S.J., Ngowi, J.R., Mwaiselage, J., Belshan, M., and Siedlik, J.A. (2021). Presence of Antibody-Dependent Cellular Cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 Plasma. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247640"},{"key":"ref_48","unstructured":"United Republic of Tanzania, Ministry of Health and Social Welfare, NACP (2007). Guidelines on HIV Testing and Counseling in Clinical Setting."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yalcin, D., Bennett, S.J., Sheehan, J., Trauth, A.J., Tso, F.Y., West, J.T., Hagensee, M.E., Ramsay, A.J., and Wood, C. (2023). Longitudinal Variations in Antibody Responses against SARS-CoV-2 Spike Epitopes upon Serial Vaccinations. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087292"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"eabd4250","DOI":"10.1126\/science.abd4250","article-title":"Viral Epitope Profiling of COVID-19 Patients Reveals Cross-Reactivity and Correlates of Severity","volume":"370","author":"Shrock","year":"2020","journal-title":"Science"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Bennett, S.J., Yalcin, D., Privatt, S.R., Ngalamika, O., Lidenge, S.J., West, J.T., and Wood, C. (2022). Antibody Epitope Profiling of the KSHV LANA Protein Using VirScan. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1011033"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41596-018-0025-6","article-title":"PhIP-Seq Characterization of Serum Antibodies Using Oligonucleotide-Encoded Peptidomes","volume":"13","author":"Mohan","year":"2018","journal-title":"Nat. Protoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"aaa0698","DOI":"10.1126\/science.aaa0698","article-title":"Viral Immunology. Comprehensive Serological Profiling of Human Populations Using a Synthetic Human Virome","volume":"348","author":"Xu","year":"2015","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41577-022-00809-x","article-title":"The Impact of Pre-Existing Cross-Reactive Immunity on SARS-CoV-2 Infection and Vaccine Responses","volume":"23","author":"Murray","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1016\/S2666-5247(20)30098-7","article-title":"Cross-Reactivity towards SARS-CoV-2: The Potential Role of Low-Pathogenic Human Coronaviruses","volume":"1","author":"Ma","year":"2020","journal-title":"Lancet Microbe"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13164","DOI":"10.1038\/s41598-021-92521-4","article-title":"Immunodominant T-Cell Epitopes from the SARS-CoV-2 Spike Antigen Reveal Robust Pre-Existing T-Cell Immunity in Unexposed Individuals","volume":"11","author":"Mahajan","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mishra, N., Kumar, S., Singh, S., Bansal, T., Jain, N., Saluja, S., Kumar, R., Bhattacharyya, S., Palanichamy, J.K., and Mir, R.A. (2021). Cross-Neutralization of SARS-CoV-2 by HIV-1 Specific Broadly Neutralizing Antibodies and Polyclonal Plasma. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009958"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Berenguer, J., D\u00edez, C., Mart\u00edn-Vicente, M., Mic\u00e1n, R., P\u00e9rez-El\u00edas, M.J., Garc\u00eda-Fraile, L.J., Vidal, F., Su\u00e1rez-Garc\u00eda, I., Podzamczer, D., and Del Romero, J. (2021). Prevalence and Factors Associated with SARS-CoV-2 Seropositivity in the Spanish HIV Research Network Cohort. Clin. Microbiol. Infect., 27.","DOI":"10.1016\/j.cmi.2021.06.023"},{"key":"ref_59","first-page":"101524","article-title":"A Case of Acquired Immunodeficiency Syndrome-Related Kaposi Sarcoma in a Patient with COVID-19\u2014A Brief Review of HIV-COVID Co-Infection and Its Therapeutic Challenges!","volume":"34","author":"Nasrullah","year":"2021","journal-title":"Respir. Med. Case Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"807","DOI":"10.15585\/mmwr.mm7022a2","article-title":"COVID-19 Severity and COVID-19\u2013Associated Deaths Among Hospitalized Patients with HIV Infection\u2014Zambia, March\u2013December 2020","volume":"70","author":"Chanda","year":"2021","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jinf.2020.10.023","article-title":"Prior Presumed Coronavirus Infection Reduces COVID-19 Risk: A Cohort Study","volume":"81","author":"Aran","year":"2020","journal-title":"J. Infect."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e143380","DOI":"10.1172\/JCI143380","article-title":"Recent Endemic Coronavirus Infection Is Associated with Less-Severe COVID-19","volume":"131","author":"Sagar","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.cell.2021.02.010","article-title":"Seasonal Human Coronavirus Antibodies Are Boosted upon SARS-CoV-2 Infection but Not Associated with Protection","volume":"184","author":"Anderson","year":"2021","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"100073","DOI":"10.1016\/j.xcrm.2020.100073","article-title":"Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: A Retrospective Cohort Study","volume":"1","author":"Moorlag","year":"2020","journal-title":"Cell Rep. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e145157","DOI":"10.1172\/JCI145157","article-title":"BCG Vaccination History Associates with Decreased SARS-CoV-2 Seroprevalence across a Diverse Cohort of Health Care Workers","volume":"131","author":"Rivas","year":"2021","journal-title":"J. Clin. 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