{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:19:15Z","timestamp":1778602755435,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iowa Pork Producers Association","award":["#12-208"],"award-info":[{"award-number":["#12-208"]}]},{"name":"Iowa Pork Producers Association","award":["5030-32000-231-000-D"],"award-info":[{"award-number":["5030-32000-231-000-D"]}]},{"name":"Iowa Pork Producers Association","award":["DE-AC05-06OR23100"],"award-info":[{"award-number":["DE-AC05-06OR23100"]}]},{"name":"Iowa Pork Producers Association","award":["0500-00093-001-00-D"],"award-info":[{"award-number":["0500-00093-001-00-D"]}]},{"name":"U.S. Department of Agriculture (USDA) Agricultural Research Service","award":["#12-208"],"award-info":[{"award-number":["#12-208"]}]},{"name":"U.S. Department of Agriculture (USDA) Agricultural Research Service","award":["5030-32000-231-000-D"],"award-info":[{"award-number":["5030-32000-231-000-D"]}]},{"name":"U.S. Department of Agriculture (USDA) Agricultural Research Service","award":["DE-AC05-06OR23100"],"award-info":[{"award-number":["DE-AC05-06OR23100"]}]},{"name":"U.S. Department of Agriculture (USDA) Agricultural Research Service","award":["0500-00093-001-00-D"],"award-info":[{"award-number":["0500-00093-001-00-D"]}]},{"name":"U.S. Department of Energy (DOE) and the USDA Agricultural Research Service","award":["#12-208"],"award-info":[{"award-number":["#12-208"]}]},{"name":"U.S. Department of Energy (DOE) and the USDA Agricultural Research Service","award":["5030-32000-231-000-D"],"award-info":[{"award-number":["5030-32000-231-000-D"]}]},{"name":"U.S. Department of Energy (DOE) and the USDA Agricultural Research Service","award":["DE-AC05-06OR23100"],"award-info":[{"award-number":["DE-AC05-06OR23100"]}]},{"name":"U.S. Department of Energy (DOE) and the USDA Agricultural Research Service","award":["0500-00093-001-00-D"],"award-info":[{"award-number":["0500-00093-001-00-D"]}]},{"name":"SCINet project of the USDA Agricultural Research Service","award":["#12-208"],"award-info":[{"award-number":["#12-208"]}]},{"name":"SCINet project of the USDA Agricultural Research Service","award":["5030-32000-231-000-D"],"award-info":[{"award-number":["5030-32000-231-000-D"]}]},{"name":"SCINet project of the USDA Agricultural Research Service","award":["DE-AC05-06OR23100"],"award-info":[{"award-number":["DE-AC05-06OR23100"]}]},{"name":"SCINet project of the USDA Agricultural Research Service","award":["0500-00093-001-00-D"],"award-info":[{"award-number":["0500-00093-001-00-D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Inactivated influenza A virus (IAV) vaccines help reduce clinical disease in suckling piglets, although endemic infections still exist. The objective of this study was to evaluate the detection of IAV in suckling and nursery piglets from IAV-vaccinated sows from farms with endemic IAV infections. Eight nasal swab collections were obtained from 135 two-week-old suckling piglets from four farms every other week from March to September 2013. Oral fluid samples were collected from the same group of nursery piglets. IAV RNA was detected in 1.64% and 31.01% of individual nasal swabs and oral fluids, respectively. H1N2 was detected most often, with sporadic detection of H1N1 and H3N2. Whole-genome sequences of IAV isolated from suckling piglets revealed an H1 hemagglutinin (HA) from the 1B.2.2.2 clade and N2 neuraminidase (NA) from the 2002A clade. The internal gene constellation of the endemic H1N2 was TTTTPT with a pandemic lineage matrix. The HA gene had 97.59% and 97.52% nucleotide and amino acid identities, respectively, to the H1 1B.2.2.2 used in the farm-specific vaccine. A similar H1 1B.2.2.2 was detected in the downstream nursery. These data demonstrate the low frequency of IAV detection in suckling piglets and downstream nurseries from farms with endemic infections in spite of using farm-specific IAV vaccines in sows.<\/jats:p>","DOI":"10.3390\/v16040626","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T07:55:54Z","timestamp":1713426954000},"page":"626","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-6530","authenticated-orcid":false,"given":"Alessandra Silva","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Preventive Veterinary Medicine, Minas Gerais State University, 6627 Antonio Carlos Avenue, Belo Horizonte 31620-295, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L. Vincent","family":"Baker","sequence":"additional","affiliation":[{"name":"Virus and Prion Research Unit, United States Department of Agriculture, National Animal Disease Center, Agricultural Research Service, 1920 Dayton Avenue, Ames, IA 50010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7228-6202","authenticated-orcid":false,"given":"Jianqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-6931","authenticated-orcid":false,"given":"Michael A.","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravina","family":"Kitikoon","sequence":"additional","affiliation":[{"name":"Virus and Prion Research Unit, United States Department of Agriculture, National Animal Disease Center, Agricultural Research Service, 1920 Dayton Avenue, Ames, IA 50010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-8769","authenticated-orcid":false,"given":"Phillip C.","family":"Gauger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011, USA"},{"name":"Phillip Gauger of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vetmic.2003.10.008","article-title":"Porcine circovirus-2 and concurrent infections in the field","volume":"98","author":"Ellis","year":"2004","journal-title":"Vet. 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