{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:44:24Z","timestamp":1791351864413,"version":"4.3.1"},"reference-count":89,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Numerous human adenovirus (AdV) types are endowed with arginine\u2013glycine\u2013aspartic acid (RGD) sequences that enable them to recognize vitronectin-binding (\u03b1v) integrins. These RGD-binding cell receptors mediate AdV entry into host cells, a crucial early step in virus infection. Integrin interactions with adenoviruses not only initiate receptor-mediated endocytosis but also facilitate AdV capsid disassembly, a prerequisite for membrane penetration by AdV protein VI. This review discusses fundamental aspects of AdV\u2013host interactions mediated by integrins. Recent efforts to re-engineer AdV vectors and non-viral nanoparticles to target \u03b1v integrins for bioimaging and the eradication of cancer cells will also be discussed.<\/jats:p>","DOI":"10.3390\/v16050770","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:26:36Z","timestamp":1715682396000},"page":"770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Integrin-Targeting Strategies for Adenovirus Gene Therapy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-1765","authenticated-orcid":false,"given":"Glen R.","family":"Nemerow","sequence":"first","affiliation":[{"name":"Department of Immunology, The Scripps Research Institute, 10666 North Torrey Pines Rd, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-61779-166-6_7","article-title":"Overview: Structural biology of integrins","volume":"757","author":"Fu","year":"2012","journal-title":"Methods Mol. 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