{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:18:03Z","timestamp":1769912283854,"version":"3.49.0"},"reference-count":50,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer","award":["RC01_70095021"],"award-info":[{"award-number":["RC01_70095021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Due to low susceptibility of coronavirus disease of 2019 (COVID-19) in children, limited studies are available regarding COVID-19 in the pediatric population in Tunisia. The current study evaluated the incidence, clinical characteristics, and outcomes of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection among children hospitalized at B\u00e9chir Hamza Children\u2019s Hospital. A retrospective cohort analysis was conducted using the hospital database between March 2020 and February 2022 with children aged \u226415 years with SARS-CoV-2 infection (confirmed by RT-PCR). A total of 327 COVID-19 hospitalized patients with a mean age of 3.3 years were included; the majority were male. Neurological disease (20%) was the most common comorbidity, while fever (95.3%) followed by cough (43.7%) and dyspnea (39.6%) were the most frequent symptoms reported. Severe disease with oxygen requirement occurred in 30% of the patients; 13% were admitted in the Intensive Care Unit. The overall incidence rate of COVID-19 hospitalization (in Tunis governorates) was 77.02 per 100,000 while the inpatient case fatality rate was 5% in the study population. The most prevalent circulating variant during our study period was Delta (48.8%), followed by Omicron (26%). More than 45% of the study population were &lt;6 months and one-fourth (n = 25, 26.5%) had at least one comorbidity. Thus, the study findings highlight the high disease burden of COVID-19 in infants.<\/jats:p>","DOI":"10.3390\/v16050779","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:26:36Z","timestamp":1715682396000},"page":"779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-9209","authenticated-orcid":false,"given":"Aida","family":"Borgi","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-8265","authenticated-orcid":false,"given":"Khaoula","family":"Meftah","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Trabelsi","sequence":"additional","affiliation":[{"name":"Pediatric Department B, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-6645","authenticated-orcid":false,"given":"Moe H.","family":"Kyaw","sequence":"additional","affiliation":[{"name":"Pfizer Inc., New York, NY 10017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hela","family":"Zaghden","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Bouafsoun","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Mezghani","sequence":"additional","affiliation":[{"name":"Pediatric Department A, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-5479","authenticated-orcid":false,"given":"Nada","family":"Missaoui","sequence":"additional","affiliation":[{"name":"Pediatric Department C, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alya","family":"Abdel Ali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Emergency, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Essaddam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Emergency, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa","family":"Khemiri","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institute Pasteur of Tunis, Tunis 1002, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-4387","authenticated-orcid":false,"given":"Sondes","family":"Haddad-Boubaker","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institute Pasteur of Tunis, Tunis 1002, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khedija","family":"Boussetta","sequence":"additional","affiliation":[{"name":"Pediatric Department B, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Khemiri","sequence":"additional","affiliation":[{"name":"Pediatric Department A, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saida","family":"Ben Becher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Emergency, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Boukthir","sequence":"additional","affiliation":[{"name":"Pediatric Department C, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Triki","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institute Pasteur of Tunis, Tunis 1002, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Menif","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-0259","authenticated-orcid":false,"given":"Hanen","family":"Smaoui","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Children\u2019s Hospital of Tunis, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref_1","unstructured":"(2023, 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