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Nevertheless, the folding of RNA virus genomes has also been identified as a critical factor in regulating canonical and non-canonical functions. Due to the influence of host ncRNAs and the structure of RNA viral genomes, complex molecular and cellular processes in infections are modulated. We propose three main categories to organize the current information about RNA\u2013RNA interactions in some well-known human viruses. The first category shows examples of host ncRNAs associated with the immune response triggered in viral infections. Even though miRNAs introduce a standpoint, they are briefly presented to keep researchers moving forward in uncovering other RNAs. The second category outlines interactions between virus-host ncRNAs, while the third describes how the structure of the RNA viral genome serves as a scaffold for processing virus-derived RNAs. Our grouping may provide a comprehensive framework to classify ncRNA\u2013host-cell interactions for emerging viruses and diseases. In this sense, we introduced them to organize DENV\u2013host-cell interactions.<\/jats:p>","DOI":"10.3390\/v16050804","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T03:26:27Z","timestamp":1716261987000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-8204","authenticated-orcid":false,"given":"Clara Isabel","family":"Bermudez-Santana","sequence":"first","affiliation":[{"name":"Computational and theoretical RNomics Group, Center of Excellence in Scientific Computing, Universidad Nacional de Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-2569","authenticated-orcid":false,"given":"Juan Carlos","family":"Gallego-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Grupo de Medicina de Traslaci\u00f3n, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.1138341","article-title":"RNA maps reveal new RNA classes and a possible function for pervasive transcription","volume":"316","author":"Kapranov","year":"2007","journal-title":"Science"},{"key":"ref_2","unstructured":"Josset, L., Tisoncik-Go, J., and Katze, M.G. 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