{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:51Z","timestamp":1790812731581,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gilead Sciences Hellas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>People living with HIV-HCV co-infection comprise a target group for HCV-micro-elimination. We conducted an HCV cascade of care (CoC) for HIV-HCV co-infected individuals living in Greece and investigated factors associated with different HCV-CoC stages. We analyzed data from 1213 participants from the Athens Multicenter AIDS Cohort Study. A seven-stage CoC, overall and by subgroup (people who inject drugs (PWID), men having sex with men (MSM), men having sex with women (MSW), and migrants], was constructed, spanning from HCV diagnosis to sustained virologic response (SVR). Logistic\/Cox regression models were employed to identify factors associated with passing through each CoC step. Among 1213 anti-HCV-positive individuals, 9.2% died before direct-acting antiviral (DAA) availability. PWID exhibited higher mortality rates than MSM. Of 1101 survivors, 72.2% remained in care and underwent HCV-RNA testing. Migrants and PWID showed the lowest retention rates. HCV-RNA was available for 79.2% of those in care, with 77.8% diagnosed with chronic HCV. Subsequently, 71% initiated DAAs, with individuals with very low CD4 counts (&lt;100 cells\/\u03bcL) exhibiting lower odds of DAA initiation. SVR testing was available for 203 individuals, with 85.7% achieving SVR. The SVR rates did not differ across risk groups. In 2023, significant gaps and between-group differences persisted in HCV-CoC among HIV-HCV co-infected individuals in Greece.<\/jats:p>","DOI":"10.3390\/v16060885","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:19:46Z","timestamp":1717417186000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HCV Cascade of Care in HIV\/HCV Co-Infected Individuals: Missed Opportunities for Micro-Elimination"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-1121","authenticated-orcid":false,"given":"Christos","family":"Thomadakis","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-872X","authenticated-orcid":false,"given":"Dimitrios","family":"Basoulis","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Tsachouridou","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, 1st Internal Medicine Department, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-746X","authenticated-orcid":false,"given":"Konstantinos","family":"Protopapas","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Paparizos","sequence":"additional","affiliation":[{"name":"AIDS Unit, Clinic of Venereologic & Dermatologic Diseases, Medical School, Syngros Hospital, National and Kapodistrian University of Athens, 161 21 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrto","family":"Astriti","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine and Infectious Diseases Unit, General Hospital of Athens G. Gennimatas, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chini","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine Infectious Diseases Unit, Red Cross General Hospital, 115 26 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Chrysos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Tzaneion General Hospital of Piraeus, 185 36 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markos","family":"Marangos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine & Infectious Diseases, Patras University General Hospital, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Panagopoulos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, 2nd University Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 681 00 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-5926","authenticated-orcid":false,"given":"Diamantis","family":"Kofteridis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Heraklion, 715 00 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-076X","authenticated-orcid":false,"given":"Helen","family":"Sambatakou","sequence":"additional","affiliation":[{"name":"HIV Unit, 2nd Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Hippokration University General Hospital, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpida","family":"Mastrogianni","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-5066","authenticated-orcid":false,"given":"Nikos","family":"Panatzis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-2550","authenticated-orcid":false,"given":"Evmorfia","family":"Pechlivanidou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Psich\u03bfgiou","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-0844","authenticated-orcid":false,"given":"Giota","family":"Touloumi","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024, March 03). The Global Health Observatory. Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/hiv-aids\/hiv-aids."},{"key":"ref_2","unstructured":"World Health Organization (2024, March 03). Hepatitis C Fact Sheet. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1473-3099(15)00485-5","article-title":"Prevalence and burden of HCV co-infection in people living with HIV: A global systematic review and meta-analysis","volume":"16","author":"Platt","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/COH.0000000000000592","article-title":"Editorial: Can we end HIV as a public health problem globally? Progress towards achieving the UNAIDS 90-90-90 goals","volume":"14","year":"2019","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_5","first-page":"321","article-title":"Aiming towards hepatitis C virus elimination in Greece","volume":"32","author":"Papatheodoridis","year":"2019","journal-title":"Ann. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/QAD.0000000000002040","article-title":"Effect of incident hepatitis C infection on CD4+ cell count and HIV RNA trajectories based on a multinational HIV seroconversion cohort","volume":"33","author":"Touloumi","year":"2019","journal-title":"AIDS"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e0110523","DOI":"10.1128\/jvi.01105-23","article-title":"DAA-mediated HCV cure reduces HIV DNA levels in HCV\/HIV coinfected people","volume":"97","author":"Gobran","year":"2023","journal-title":"J. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Marchetti, G., for the Icona Foundation Study Group, Cozzi-Lepri, A., Tincati, C., Calcagno, A., Ceccherini-Silberstein, F., De Luca, A., Antinori, A., Castagna, A., and Puoti, M. (2014). Immune activation and microbial translocation in liver disease progression in HIV\/hepatitis co-infected patients: Results from the Icona Foundation study. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-79"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/COH.0000000000000179","article-title":"The hepatitis C virus epidemics in key populations (including people who inject drugs, prisoners and MSM): The use of direct-acting antivirals as treatment for prevention","volume":"10","author":"Martin","year":"2015","journal-title":"Curr. Opin. HIV AIDS"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yehia, B.R., Schranz, A.J., Umscheid, C.A., and Re, V.L. (2014). The Treatment Cascade for Chronic Hepatitis C Virus Infection in the United States: A Systematic Review and Meta-Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101554"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"ofz361","DOI":"10.1093\/ofid\/ofz361","article-title":"Implementing a Comprehensive Hepatitis C Virus (HCV) Clinic Within a Human Immunodeficiency Virus Clinic: A Model of Care for HCV Microelimination","volume":"6","author":"Rizk","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/cid\/ciq243","article-title":"The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection","volume":"52","author":"Gardner","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bar, N., Bensoussan, N., Rabinowich, L., Levi, S., Houri, I., Shor, D.B.-A., Shibolet, O., Mor, O., Weitzman, E., and Turner, D. (2022). Barriers and Facilitators of Hepatitis C Care in Persons Coinfected with Human Immunodeficiency Virus. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192215237"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1177\/15248399231169793","article-title":"Characterizing Persons With HIV\/HCV Coinfection Who Remain Untreated for Hepatitis C at Four HIV Clinics in Connecticut (CT): Role of Multiple Overlapping Barriers at the Individual and Clinic System Levels","volume":"24","author":"Zhao","year":"2023","journal-title":"Health Promot. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1093\/infdis\/jiaa686","article-title":"Direct-Acting Antiviral Hepatitis C Treatment Cascade and Barriers to Treatment Initiation Among US Men and Women With and Without HIV","volume":"223","author":"Haley","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/jvh.13178","article-title":"A hepatitis C outbreak preceded the HIV outbreak among persons who inject drugs in Athens, Greece: Insights from a mathematical modelling study","volume":"26","author":"Gountas","year":"2019","journal-title":"J. Viral Hepat."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Paraskevis, D., Nikolopoulos, G., Fotiou, A., Tsiara, C., Paraskeva, D., Sypsa, V., Lazanas, M., Gargalianos, P., Psichogiou, M., and Skoutelis, A. (2013). Economic Recession and Emergence of an HIV-1 Outbreak among Drug Injectors in Athens Metropolitan Area: A Longitudinal Study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078941"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/add.12999","article-title":"Design and baseline findings of a large-scale rapid response to an HIV outbreak in people who inject drugs in Athens, Greece: The ARISTOTLE programme","volume":"110","author":"Hatzakis","year":"2015","journal-title":"Addiction"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104073","DOI":"10.1016\/j.drugpo.2023.104073","article-title":"A new outbreak of HIV infection among people who inject drugs during the COVID-19 pandemic in Greece","volume":"117","author":"Sypsa","year":"2023","journal-title":"Int. J. Drug Policy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/QAD.0000000000002248","article-title":"Long-term evolution of CD4+ cell count in patients under combined antiretroviral therapy","volume":"33","author":"Pantazis","year":"2019","journal-title":"AIDS"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/QAD.0000000000003131","article-title":"HIV continuum of care: Bridging cross-sectional and longitudinal analyses","volume":"36","author":"Touloumi","year":"2021","journal-title":"AIDS"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/sextrans-2020-054697","article-title":"Tracking missed opportunities for an early HIV diagnosis in a population of people living with HIV with known time of infection","volume":"98","author":"Basoulis","year":"2021","journal-title":"Sex. Transm. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/hiv.13415","article-title":"Estimation of the determinants for HIV late presentation using the traditional definition and molecular clock-inferred dates: Evidence that older age, heterosexual risk group and more recent diagnosis are prognostic factors","volume":"23","author":"Kostaki","year":"2022","journal-title":"HIV Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"104356","DOI":"10.1016\/j.drugpo.2024.104356","article-title":"High levels of all-cause mortality among people who inject drugs from 2018 to 2022","volume":"126","author":"Roussos","year":"2024","journal-title":"Int. J. Drug Policy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1080\/09540121.2021.1981221","article-title":"Effects of direct-acting antiviral treatment on reducing mortality among Medicare beneficiaries with HIV and HCV coinfection","volume":"34","author":"Yin","year":"2022","journal-title":"AIDS Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1572-0241.2006.00531.x","article-title":"Racial Difference in Mortality among U.S. Veterans with HCV\/HIV Coinfection","volume":"101","author":"Porter","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1177\/15248399231169919","article-title":"Future Directions for HIV\/HCV Care: Lessons Learned from Local Evaluation Projects in Texas and Connecticut and Implications for Practice and Health Promotion","volume":"24","author":"Villanueva","year":"2023","journal-title":"Health Promot. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cachay, E.R., Hill, L., Wyles, D., Colwell, B., Ballard, C., Torriani, F., and Mathews, W.C. (2014). The Hepatitis C Cascade of Care among HIV Infected Patients: A Call to Address Ongoing Barriers to Care. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102883"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1177\/15248399231169792","article-title":"Creating a Longitudinal HCV Care Cascade for Persons with HIV\/HCV Coinfection in Selected HIV Clinics Using Data to Care Methods","volume":"24","author":"Brooks","year":"2023","journal-title":"Health Promot. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1097\/QAD.0000000000001928","article-title":"Uptake of hepatitis C virus treatment in HIV\/hepatitis C virus-coinfected patients across Europe in the era of direct-acting antivirals","volume":"32","author":"Peters","year":"2018","journal-title":"AIDS"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/QAD.0000000000003112","article-title":"The hepatitis C cascade of care in HIV\/hepatitis C virus coinfected individuals in Europe: Regional and intra-regional differences","volume":"36","author":"Fursa","year":"2021","journal-title":"AIDS"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1080\/14656566.2021.1921737","article-title":"An update on direct antiviral agents for the treatment of hepatitis C","volume":"22","author":"Stanciu","year":"2021","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e26048","DOI":"10.1002\/jia2.26048","article-title":"Sustained virological response after treatment with direct antiviral agents in individuals with HIV and hepatitis C co-infection","volume":"25","author":"Lodi","year":"2022","journal-title":"J. Int. AIDS Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/hiv.13280","article-title":"Viral hepatitis and the cascade of care among people living with HIV in the Asia-Pacific","volume":"23","author":"Rupasinghe","year":"2022","journal-title":"HIV Med."},{"key":"ref_35","first-page":"374","article-title":"Comparative outcomes of direct-acting antiviral treatment in patients with HIV-Hepatitis C co-infection: Insights from a single center experience in Colombia","volume":"31","author":"Ortiz","year":"2023","journal-title":"Infez. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijid.2017.07.001","article-title":"HCV mono-infected and HIV\/HCV co-infected individuals treated with direct-acting antivirals: To what extent do they differ?","volume":"62","author":"Bruno","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jinf.2019.10.019","article-title":"Higher sustained virological response rates at 12 weeks in HIV-HCV co-infection; a tertiary centre experience","volume":"80","author":"Carvalho","year":"2020","journal-title":"J. Infect."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/QAD.0000000000002034","article-title":"Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?","volume":"33","author":"Vourli","year":"2019","journal-title":"AIDS"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/6\/885\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:51:27Z","timestamp":1760107887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/6\/885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["v16060885"],"URL":"https:\/\/doi.org\/10.3390\/v16060885","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]}}}