{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:56:45Z","timestamp":1776002205558,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONAHCYT","doi-asserted-by":"publisher","award":["238868"],"award-info":[{"award-number":["238868"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human adenovirus-36 (HAdV-36) infection has been linked to obesity, low lipid levels, and improvements in blood glucose levels and insulin sensitivity in animal models and humans, although epidemiological studies remain controversial. Therefore, this study investigated the relationship between HAdV-36 seropositivity and glycemic control in youths. This observational study examined 460 youths (246 with normal weight and 214 obese subjects). All participants underwent assessments for anthropometry, blood pressure, circulating fasting levels of glucose, lipids, insulin, and anti-HAdV-36 antibodies; additionally, the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. In all, 57.17% of the subjects were HAdV-36 seropositive. Moreover, HAdV-36 seroprevalence was higher in obese subjects compared to their normal weight counterparts (59% vs. 55%). BMI (33.1 vs. 32.3 kg\/m2, p = 0.03), and waist circumference (107 vs. 104 cm, p = 0.02), insulin levels (21 vs. 16.3 \u00b5U\/mL, p = 0.003), and HOMA-IR (4.6 vs. 3.9, p = 0.02) were higher in HAdV-36-positive subjects with obesity compared to seronegative subjects. In the obese group, HAdV-36 seropositivity was associated with a reducing effect in blood glucose levels in a model adjusted for total cholesterol, triglyceride levels, age and sex (\u03b2 = \u221210.44, p = 0.014). Furthermore, a statistically significant positive relationship was observed between HAdV-36 seropositivity and insulin levels in the obesity group. These findings suggest that natural HAdV-36 infection improves glycemic control but does not ameliorate hyperinsulinemia in obese subjects.<\/jats:p>","DOI":"10.3390\/v16060922","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:50:09Z","timestamp":1717588209000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Observational Study Suggests That Natural HAdV-36 Infection Decreases Blood Glucose Levels without Affecting Insulin Levels in Obese Young Subjects"],"prefix":"10.3390","volume":"16","author":[{"given":"In\u00e9s","family":"Matia-Garcia","sequence":"first","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Biological Chemistry Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo 39087, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Adalberto","family":"Ocampo-Galeana","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Biological Chemistry Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo 39087, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-9260","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[{"name":"Research Institute in Biomedical Sciences, University Center for Health Science, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Guadalupe","family":"So\u00f1anez-Organis","sequence":"additional","affiliation":[{"name":"Department of Biological and Agricultural Chemistry Sciences, University of Sonora, Campus Navojoa, Navojoa 85880, Sonora, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-8529","authenticated-orcid":false,"given":"Ram\u00f3n A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Research Center in Cellular Dynamics, Research Institute in Basic and Applied Sciences, Autonomous University of the State of Morelos, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1535-4226","authenticated-orcid":false,"given":"Iris Paola","family":"Guzm\u00e1n-Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Biological Chemistry Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo 39087, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Anahi","family":"Marino-Ortega","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Biological Chemistry Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo 39087, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-8263","authenticated-orcid":false,"given":"Isela","family":"Parra-Rojas","sequence":"additional","affiliation":[{"name":"Obesity and Diabetes Research Laboratory, Faculty of Biological Chemistry Sciences, Autonomous University of Guerrero, Chilpancingo de los Bravo 39087, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2794S","DOI":"10.1093\/jn\/131.10.2794S","article-title":"Infectobesity: Obesity of Infectious Origin","volume":"131","author":"Dhurandhar","year":"2001","journal-title":"J. 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