{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T21:15:33Z","timestamp":1765142133203,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNETE Research Fund","award":["UNT15-004","SOCHED #2021-04"],"award-info":[{"award-number":["UNT15-004","SOCHED #2021-04"]}]},{"name":"Chilean Society of Endocrinology and Diabetes","award":["UNT15-004","SOCHED #2021-04"],"award-info":[{"award-number":["UNT15-004","SOCHED #2021-04"]}]},{"name":"National Agency of Research and Development (ANID-Chile)","award":["UNT15-004","SOCHED #2021-04"],"award-info":[{"award-number":["UNT15-004","SOCHED #2021-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Background: Previous infection with Adenovirus-36 (HAdv-D36) has been associated with adipogenesis and glycemic regulation in cell culture and animal models. In humans, HAdv-D36 antibodies correlate with increased obesity risk yet paradoxically enhance glycemic control across various demographics. This study assesses the association of HAdv-D36 seropositivity with obesity, lipid, and glycemic profiles among school-aged children. Methods: We evaluated 208 children aged 9\u201313, categorized by BMI z-scores into normal weight (\u22121 to +1), overweight (+1 to +2), and obese (&gt;+3). Assessments included anthropometry, Tanner stage for pubertal development, and biochemical tests (relating to lipids, glucose, and insulin), alongside HAdv-D36 seropositivity checked via ELISA. Insulin resistance was gauged using Chilean pediatric criteria. Results: The cohort displayed a high prevalence of overweight\/obesity. HAdv-D36 seropositivity was 5.4%, showing no correlation with nutritional status. Additionally, no link between HAdv-D36 seropositivity and lipid levels was observed. Notably, insulin levels and HOMA-RI were significantly lower in HAdv-D36 positive children (p &lt; 0.001). No cases of insulin resistance were reported in the HAdv-D36 (+) group in our population. Conclusions: HAdv-D36 seropositivity appears to decrease insulin secretion and resistance, aligning with earlier findings. However, no association with obesity development was found in the child population of southern Chile.<\/jats:p>","DOI":"10.3390\/v16060995","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:10:28Z","timestamp":1718968228000},"page":"995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of Seropositivity against Adenovirus-36 on the Risk of Obesity and Insulin Resistance in the Child Population of Southern Chile"],"prefix":"10.3390","volume":"16","author":[{"given":"Roberto","family":"Brito","sequence":"first","affiliation":[{"name":"Center of Excellence in Translational Medicine CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sapunar","sequence":"additional","affiliation":[{"name":"Center of Excellence in Translational Medicine CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile"},{"name":"Department of Internal Medicine, Universidad de La Frontera, Temuco 4781176, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-1312","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Aguilar-Far\u00edas","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Sports and Recreation, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Navarro-Riquelme","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Children\u2019s Surgery, Universidad de La Frontera, Temuco 4781176, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Pavez","sequence":"additional","affiliation":[{"name":"Center of Excellence in Translational Medicine CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile"},{"name":"Department of Internal Medicine, Universidad de La Frontera, Temuco 4781176, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-7979","authenticated-orcid":false,"given":"Mario Hiroyuki","family":"Hirata","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-060, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-8332","authenticated-orcid":false,"given":"Alvaro","family":"Cerda","sequence":"additional","affiliation":[{"name":"Center of Excellence in Translational Medicine CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile"},{"name":"Department of Basic Sciences, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0140-6736(05)67483-1","article-title":"Obesity","volume":"366","author":"Haslam","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/pch\/14.3.177","article-title":"Childhood obesity and cardiovascular disease","volume":"14","author":"Bridger","year":"2009","journal-title":"Paediatr. 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