{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:18:00Z","timestamp":1790371080225,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009609","name":"Fondo de Apoyo a la Investigaci\u00f3n Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d","doi-asserted-by":"publisher","award":["FOSISS-2015-2-261307"],"award-info":[{"award-number":["FOSISS-2015-2-261307"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"Fondo de Apoyo a la Investigaci\u00f3n Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d","doi-asserted-by":"publisher","award":["HIM\/2019\/062"],"award-info":[{"award-number":["HIM\/2019\/062"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"Fondo de Apoyo a la Investigaci\u00f3n Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d","doi-asserted-by":"publisher","award":["HIM\/2016\/021"],"award-info":[{"award-number":["HIM\/2016\/021"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009609","name":"Fondo de Apoyo a la Investigaci\u00f3n Hospital Infantil de M\u00e9xico \u201cFederico G\u00f3mez\u201d","doi-asserted-by":"publisher","award":["HIM\/2020\/017"],"award-info":[{"award-number":["HIM\/2020\/017"]}],"id":[{"id":"10.13039\/501100009609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pediatric solid organ transplant (SOT) recipients face a challenging balance between immunosuppression and graft rejection. While Epstein\u2013Barr Virus (EBV) and cytomegalovirus (HCMV) are known contributors to post-transplant lymphoproliferative disease and graft rejection, respectively, the roles of herpesvirus 6 and 7 (HHV6 and HHV7) and the impact of these herpesviruses on cytokine levels remain unclear, leading to gaps in clinical practice. In this associative study, we measured 17 cytokines using a Bio-Plex assay in a meticulously curated plasma sample pool (N = 158) from pediatric kidney and liver transplant recipients over a one-year follow-up period. The samples included virus-negative and virus-positive cases, either individually or in combination, along with episodes of graft rejection. We observed that the elevation of IL-4, IL-8, and IL-10 correlated with graft rejection. These cytokines were elevated in samples where HCMV or HHV6 were detected alone or where EBV and HHV7 were co-detected. Interestingly, latent EBV, when detected independently, exhibited an immunomodulatory effect by downregulating cytokine levels. However, in co-detection scenarios with \u03b2-herpesviruses, EBV transitioned to a lytic state, also associating with heightened cytokinemia and graft rejection. These findings highlight the complex interactions between the immune response and herpesviruses in transplant recipients. The study advocates for enhanced monitoring of not only EBV and HCMV but also HHV6 and HHV7, providing valuable insights for improved risk assessment and targeted interventions in pediatric SOT recipients.<\/jats:p>","DOI":"10.3390\/v16071067","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T09:01:39Z","timestamp":1719910899000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytokine Dynamics and Herpesvirus Interactions in Pediatric Liver and Kidney Transplant Recipients: The Distinct Behavior of HCMV, HHV6, HHV7 and EBV"],"prefix":"10.3390","volume":"16","author":[{"given":"Yessica","family":"S\u00e1nchez-Ponce","sequence":"first","affiliation":[{"name":"Research Unit in Virology and Cancer, Children\u2019s Hospital of Mexico Federico G\u00f3mez, Mexico City 06720, Mexico"},{"name":"Postgraduate Program in Biological Science, National Autonomous University of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Rafael","family":"Murillo-Eliosa","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Children\u2019s Hospital of Mexico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-6716","authenticated-orcid":false,"given":"Abigail","family":"Morales-Sanchez","sequence":"additional","affiliation":[{"name":"Research Unit in Virology and Cancer, Children\u2019s Hospital of Mexico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-0459","authenticated-orcid":false,"given":"Ezequiel M.","family":"Fuentes-Panan\u00e1","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Children\u2019s Hospital of Mexico Federico G\u00f3mez, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kawaguchi, Y., Mori, Y., and Kimura, H. 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